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Posts by Max_Yun

PhD position @ YUN lab CRTD & MPI CBG Germany

Posted by , on 24 September 2020

The research group of Dr Max Yun, ‘Regeneration of Complex Structures in Adult Vertebrates’ at DFG/CRTD Center for Regenerative Therapies Dresden (Germany) & MPI-CBG is searching for a PhD candidate. ...

Cellular Senescence in Regeneration

Posted by , on 28 June 2015

Salamanders are remarkable organisms. Following the amputation or loss of complex structures such as parts of their eyes, hearts and brains, tails -including the spinal cord-, jaws and even full ...

Recent comments by Max_Yun

Dear Manuel, thank you for your comment. The reason for stressing this possibility is that the timing and distribution of senescent cells in the regenerate suggest that these cells could be actively induced during the process (rather than being just a result of the initial tissue injury), and the fact that these senescent cells secrete a variety of compounds as part of their senescent phenotype (such as growth factors, MMPs, TIMPS and chemokines) that affect their microenvironment and could promote tissue remodelling. Indeed, transient positive functions for senescent cells have been reported during mouse development. However, these cells need to be eventually cleared, as their persistence leads to tissue disruption and malfunction – for example, their secretory phenotype can lead to permanent inflammation and ‘constant’ tissue remodelling. Basically, the evidence that is gradually accumulating suggests that senescent cells can act as a double-edged sword: they can have positive functions, when transient, but lead to negative effects in tissues, when permanent. This is why, in light of our observations during regeneration of complex structures, I suggest that the senescent cells that appear during regeneration of complex structures could play a positive role, but then they need to be eliminated by this highly efficient mechanism of immunesurveillance so they do not exert any negative effects in the new structure or future regeneration rounds. Yet, whether they contribute to the process is still in the realm of the hypothetical - I hope I will be able to tell you more on this soon, as it is an issue that I am currently addressing.
by Max_Yun in Cellular Senescence in Regeneration on July 2, 2015