BBSRC EASTBIO-funded PhD: Control of the ParaHox genes in chordate evolution and development

Supervisors: Dr David Ferrier (University of St Andrews) and Prof Kate Storey (University of Dundee)

This project will dissect the regulatory mechanisms of the chordate ParaHox genes (Gsx, Xlox/Pdx1 and Cdx), analysing regulatory elements of these genes in both the invertebrate sea squirt Ciona intestinalis and the vertebrate Gallus gallus (chicken). ParaHox genes are the evolutionary sisters to the Hox genes, and like their sisters are important components of axial patterning, mainly in the central nervous system and gut. They also tend to have a clustered organisation in the genome that is likely linked to how the genes are regulated. Mis-regulation of ParaHox genes can cause diseases such as diabetes and colon cancer, and changes to the Hox/ParaHox genes are important agents in the evolution of animal form.

In this project, we will capitalize on the power of the comparative approach to deduce underlying fundamental aspects of body axis patterning by regulation of the ParaHox genes.

The student will obtain training in cutting-edge techniques in molecular biology, embryology, bioimaging and bioinformatics and be part of the enthusiastic and vibrant research communities in the Universities of St Andrews and Dundee, benefitting from the complementary strengths, strong links and close proximity of these institutions.

Funding Notes

Applications for BBSRC EASTBIO studentships are invited from excellent UK students (and EU citizens if they meet UK Research Council residency criteria) with at least a BSc (Hons) 2.1 undergraduate degree.

More information.

e-mail: dekf@st-andrews.ac.uk

https://www.findaphd.com/search/ProjectDetails.aspx?PJID=90025&LID=1443

How to apply?

https://synergy.st-andrews.ac.uk/research/phd-study/

Application deadline: 4^th December 2017.

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