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June in preprints

Posted by on July 1st, 2020

Welcome to our monthly trawl for developmental biology (and related) preprints.  Preprints hosted on bioRxiv and arXiv, use these links to get to the section you want.   Developmental biology | Patterning & signalling | Morphogenesis & mechanics | Genes & genomes | Stem cells, regeneration & disease modelling | Plant development Evo-devo & evo Cell biology Modelling Tools &[…]

Now we need arrest… A long journey into the end-of-flowering

Posted by on June 29th, 2020

By Tom Bennett & Catriona Walker   25th May 2020: Publication TB: The joy of seeing an article finally published is always slightly tempered by the long-drawn out process of peer review, re-writing, re-submission, re-review, proof-reading, required to get to that point. But the publication of our article ‘Auxin export from proximal fruit drives arrest[…]

The story of my heart, from the bottom of my heart (says the Zebrafish)

Posted by on June 23rd, 2020

I started off as quite little—just one cell, in fact. No heart, no brain, no blood flowed in me and yet, somehow I found the motivation in me to divide. One me made two and two mes made four, till many tiny mes made me a full-fledged embryo with a heart full of hope. As[…]

Pregnancy complications in assisted reproduction linked to a specific process

Posted by on June 9th, 2020

A Press Release from the University of Pennsylvania School of Medicine – see the Development paper by Lisa Vrooman, Marisa Bartolomei and colleagues here. An experimental study from researchers in the Perelman School of Medicine at the University of Pennsylvania links a specific procedure – embryo culture – that is part of the assisted reproduction[…]

Research Highlight #5: Leukemic stem cells from iPSCs

Posted by on June 9th, 2020

Today let’s delve into a curious case involving induced pluripotent stem cells (iPSCs) and leukemic stem cells (LSCs). Most blood cells derived from iPSCs are unable to engraft in immunodeficient mice. However, Wesely and colleagues observed an exceptionally high engraftment efficiency of cell lines derived from an individual affected by acute myeloid leukemia (AML). In[…]

Catch Me if You Can: An elusive underpinning for Arx(GCG)10+7-mediated apoptosis in X-linked infantile spasms syndrome

Posted by on June 3rd, 2020

This post highlights the approach and finding of a new research article published by Disease Models and Mechanisms (DMM). This feature is written by Olivia Howell as apart of a seminar at The University of Alabama (taught by DMM Editorial Board member, Prof. Guy Caldwell) on current topics related to use of animal and cellular[…]

Stripe by stripe, zebrafish model provides transparent look into Fibrolamellar Carcinoma mechanism

Posted by on June 3rd, 2020

This post highlights the approach and finding of a new research article published by Disease Models and Mechanisms (DMM). This feature is written by Joseph I. Kaluzny as apart of a seminar at The University of Alabama (taught by DMM Editorial Board member, Prof. Guy Caldwell) on current topics related to use of animal and[…]

May in preprints

Posted by on June 1st, 2020

Welcome to our monthly trawl for developmental biology (and related) preprints.    A real monster of a month, May, with masses of preprints uploaded by scientists in various stages of lockdown. Let us know if we missed anything and use these links to get to the section you want:   Developmental biology | Patterning & signalling[…]

Research Highlight #4: Macrophages in human development

Posted by on June 1st, 2020

Today we return our interest to human development, focusing on a special blood cell: the macrophage. Produced in multiple, stem cell-independent waves, macrophages colonize the developing foetus early on, forming several tissue-resident populations. This includes the microglia which are essential for brain and spinal cord development. In this paper, the authors looked into macrophage development[…]

Research Highlight #3: IL-1 regulates haematopoietic stem cell pool size via PU.1

Posted by on May 25th, 2020

Today, we move to mouse adult haematopoiesis, with an elegant work on inflammation and stem cell biology. As always, feedback is more than welcome! Chronic inflammation is one of the classic events underlying aging and infection response. When associated with loss of quiescence in haematopoietic stem cells (HSCs), it is commonly the initiating event in[…]