Stress responses require proper communication and orchestration between organelles critical for key decisions in cell survival and death, and crosstalk between networks is required to properly join stress responses with metabolic pathways compartmentalized within distinct organelles. Dysregulated organelle networks are increasingly implicated in cell and tissue dysfunction governing disease mechanisms, including inflammation. For example, the inability of nuclear DNA repair proteins to localize to and act on mitochondrial DNA elicits the release of damage-associated molecular patterns (DAMPs) that trigger inflammatory signalling cascades. Similarly, lysosomal dysfunction can perturb mitochondrial activity, leading to metabolic impairment and DAMP-induced inflammation. This interdisciplinary meeting will bring together experts working on genome instability, organelle biology and immunity to advance understanding of organelle stress communication mechanisms in homeostatic and pathological settings including cancer, metabolic and neurologic diseases, and aging.

Key Sessions

Interactive talks and panel discussions will cover the following topics:
•    Mitochondria-Nuclear Crosstalk in DNA Damage Responses
•    Mitochondria-ER-Lysosome Crosstalk and Quality Control
•    DNA Damage Responses and Inflammation
•    Organelles in Innate Immune Signalling
•    Organelle Communication in Metabolic and Inflammatory Diseases
•    Organelle Communication in Neurodegeneration and Aging
•    Organelle Communication in Cancer

Educational Need

Despite growing appreciation for inter-organelle communication in health and disease, there are few avenues for researchers to come together and develop a wholistic understanding of organelle crosstalk. By focusing on stress responses, the goal of this meeting is to stimulate the cross-fertilization of ideas between scientists working in diverse areas of genome stability, organelle biology, inflammation, and disease to nucleate new collaborations and shape research questions in this rapidly advancing field. Moreover, this meeting will be an exceptional opportunity for students, postdocs, and junior group leaders to meet leading researchers in various fields (i.e. genome stability, organelle dynamics, mitochondrial biology, innate immunity, cancer, metabolic disease, aging, etc.), while building mentoring networks and receiving feedback on their ongoing work.

Important Deadlines

Early Bird – 01 May 2025
Talk Submission – 01 May 2025
Poster Submission – 14 Aug 2025
Registration Deadline – 14 Aug 2025

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