3-year Postdoc and Research Assistant posts in stem cell biology-Tsakiridis group, University of Sheffield

The Tsakiridis group is looking to appoint a Postdoctoral Researcher and a Research Assistant to work on a Yorkshire Cancer Research (YCR)-funded project at the interface of stem cell biology and disease modelling.

The successful Postdoctoral Researcher applicant will employ genetic engineering to generate human embryonic stem cell (hESC) lines with defined sets of inducible tumour-associated genetic lesions that are relevant to a wide range of paediatric and adult cancers. The resulting resource will be employed for detailed downstream phenotypic characterisation as well as drug discovery via high throughput screening. Applicants must hold a PhD (or be close to completion/have equivalent experience) in a subject related to cell/stem cell/developmental biology. Experience in culture and genetic modification of hESCs alongside immunocytochemistry, flow cytometry and qPCR are desirable. Good theoretical knowledge of neural/neural crest development as well as in vitro differentiation of hESCs would be advantageous. The successful candidate will be expected to have excellent interpersonal, written and communication skills, and be able to work to a high standard. To apply see here.

The successful Research Assistant applicant will provide support for routine hESC culture and differentiation, preparation of samples and analysis. General lab management duties will also be required. Applicants must have a strong background in stem cell/developmental biology and experience with the following techniques: cell culture, RNA isolation; quantitative real time PCR; immunostaining; fluorescence/confocal microscopy; flow cytometry. To apply see here.

Deadline=17th June 2024. For informal enquiries contact a.tsakiridis@sheffield.ac.uk