Phd position in enteric neuroscience

The Marklund lab addresses fundamental research questions in Enteric Nervous System (ENS) biology with a focus on neural cell diversity. The team has identified molecularly distinct enteric neuronal and glial cell types as well as a new conceptual model for how neuron types emerge during ENS development (Morarach et al., 2021). These discoveries form the basis for an ERC-funded project which seeks to uncover molecular programs controlling cell fate decisions during embryonic and adult neurogenesis and applying these insights to engineer specific neuron types within the adult gut wall. A wide range of transcriptomic (spatial and regular), epigenetic, transgenic and imaging methodologies are utilized to meet these aims. By resolving mechanisms of ENS development, the lab hopes to pave the way for a better understanding, characterization and treatment of prevalent gut disorders. More information can be found at: https://ki.se/en/mbb/ulrika-marklund-group and www.marklundlab.org

We have an open position for a doctoral student to mainly investigate enteric glia cell diversity and address 1) how the enteric glia composition is established 2) the function of enteric glia types, 3) the role of enteric glia in neuronal regeneration.The initial work will include the analysis and manipulation of transgenic mouse models to study enteric glia morphologies, their functions and neural fate potential. The student will generate and analyse spatial and regular transcriptomic data independently or work closely with a collaborating bioinformatician.

We are seeking a enthusiastic and communicative student with a solid academic education in molecular biology, bioinformatics, neuroscience and/or developmental biology. The project will involve collaboration with other lab members as well as external collaborators why the student must possess interpersonal skills and a good ability to work in teams. Skills/experience in one or more of the following areas are required: transgenic animal models, histochemistry & advanced imaging methods, cell differentiation analysis, gene manipulation technologies, RNA/chromatin omics and/or bioinformatics.

The Marklund lab is part of the Unit of Molecular Neurobiology with strong collaborative structure and a highly stimulating and dynamic research atmosphere. For further information on the research unit: https://ki.se/en/mbb/research-division-of-molecular-neurobiology. The group resides in Biomedicum, Karolinska Institutet (Solna) providing modern technological platforms and an open environment for interactions across departments and disciplines.

Use this link to apply: https://kidoktorand.varbi.com/en/what:job/jobID:728015/type:job/where:4/apply:1