Postdoc in neural development

A post-doc is available in Nick Greene’s group at UCL Institute of Child Health, London, UK. The overall goals of our research are to investigate the causes and to develop novel therapies for disorders of the central nervous system. We have a particular focus on understanding how genetic and nutritional modulation of one-carbon metabolism affects development and function of the CNS.

A Post-doctoral position is open to join our group working on an MRC-funded programme in which we aim to understand how impaired function of the glycine decarboxylase (GLDC) protein leads to disorders of brain development and function. GLDC plays crucial roles at several stages of development and mutation of GLDC leads to disorders that include neural tube defects, congenital hydrocephalus and the neurometabolic disease, Non-Ketotic Hyperglycinemia (NKH).

This programme will investigate GLDC function at a series of stages in the CNS through neural tube closure, subsequent forebrain development and post-natally. The programme will make use of established and novel mouse lines and cellular models (including iPSC-derived organoids), together with a range of technical approaches including transcriptomics, metabolomics and advanced imaging.

We are seeking post-docs with experience in relevant fields such as developmental biology, neurobiology or cell biology. Experience in transcriptomics, including scRNA-seq, is desirable. Prior use of mouse models, cell culture and/or microscopy will also be beneficial.

The post(s) is available for 3 years initially and informal enquiries can be made to Nick Greene (n.greene@ucl.ac.uk)