Postdoctoral Position in Gene Regulation and Nuclear Organization

Who we are:

Our lab studies how genome folding not only fits DNA within the constraints of the nuclear space but also is used as a critical mechanism of gene regulation. This is particularly important during development because perturbation of gene expression causes severe birth defects. We have shown that variations of just a few nucleotides of DNA sequence, can disrupt genome architecture, dysregulate gene expression, and severely compromise mammalian development. In addition, some of the animal models we developed are being used to test therapies for defects caused by abnormal genome structure. While centered on embryogenesis, our work sheds light on how cell type-specific transcriptional programs are established, with broad implications for cell fate decisions in other disease contexts such as cancer.

Learn more about our research.

Our principles:

We strive to create an engaging and fun environment to do science. We value rigorous work, ingenuity, and creativity. We like to collaborate, share ideas and technologies, and preprint all our work as soon as we submit to peer-review journals. We are looking for people who like to work on a team, teach, and learn. We also seek a wide variety of scientific backgrounds.

What we offer:

With more than 1,000 labs, NIH offers unique collaborative opportunities and world-experts from all fields of biomedical science, combined with core facilities equipped with the most cutting-edge technology. The lab is in Bethesda, Maryland, which offers an affordable suburban lifestyle with access to excellent public schools. It is also just 15 minutes away by Metro from downtown Washington D.C., a vibrant city with vast cultural offerings, such as international restaurants, museums, art galleries, concert venues, and much more to explore.

Postdoctoral positions at NIH are fully funded. Postdocs will be able to start their own research program or lead ongoing projects.

How to apply:

We are looking for people who share our enthusiasm for gene regulation, nuclear organization, and mouse development. Ph.D.-level experience in at least one of the following is required: mouse development, mouse genetics, epigenetics, massively parallel sequencing-based techniques, or computational biology.

Please write a 2-paragraph cover letter explaining your scientific trajectory and why you would like to join us. Send it, together with your CV and contacts for 3 references, to pedro.rocha@nih.gov.