Postdoctoral Research Fellow or PhD in Cardiovascular Genetics

A PhD or postdoctoral research fellow position is available in the laboratories of Alexandre Dubrac and Gregor Andelfinger at the CHU Sainte Justine Research Center, Montréal, Québec, Canada. Our work focuses on the genetic mechanisms of pediatric cardiovascular diseases and includes genomics, cell biology, mouse models, and functional approaches. This project is entirely focused on multisystemic smooth muscle dysfunction syndrome (MSMDS), caused by ACTA2 mutations, and aims to elucidate novel therapeutic opportunities with the help of mouse and hiPSC disease models. The successful candidate will have a unique opportunity to do interdisciplinary research at all interfaces from molecular and cellular biology to translational medicine, and publish their results in high impact journals. This project will be jointly co-supervised by both principal investigators, and is already fully funded.

We expect collaboration, motivation and independent thinking, and offer a supportive environment for learning and translational exposure. Experience molecular and cellular biology, stem cell culture, mouse models, and confocal microscopy is desired. Additional expertise in state-of-the art techniques (i.e., hiPSC culture, scRNAseq, bioinformatics) will be an asset.

The successful candidate preferably has a recent Ph.D. degree in life sciences or a related field. We are seeking highly motivated researchers with excellent oral, written and interpersonal communication skills. Applications at the Ph.D. level will also be considered.

The CHU Sainte Justine Research Center has a productive scientific community and recently moved into a brand-new building with required state-of-the-art infrastructure, including platforms for stem cell generation and gene editing, microscopy, and flow cytometry.

Montreal is a vibrant multicultural city with a high quality of life. With a greater metropolitan area of 3.5 M, Montreal offers all scientific and cultural benefits of a large North American agglomeration with European flair and beautiful surroundings.

Interested applicants are asked to provide the following documents to alexandre.dubrac.hsj@ssss.gouv.qc.ca or gregor.andelfinger.med@ssss.gouv.qc.ca:

• CV
• Cover letter describing previous experience and career goals
• Contact information for 3 references