Research Fellow in Developmental Biology and Cancer

We are looking for a researcher with experience in mouse genetics, embryology and tumorigenesis to work on a research programme focussed on childhood pituitary tumours. The post will be based within the new Birth Defects Research Centre, at the UCL Institute of Child Health. Further details can be obtained at http://www.ucl.ac.uk/child-health/research/developmental-biology-and-cancer/developmental-biology-birth-defects

We are using preclinical models of paediatric brain cancer to study the role of senescence in the pathogenesis of these cancers as well as to evaluate the efficacy of senolytics. We have generated mouse models that resemble human adamantinomatous craniopharyngioma and revealed a mechanism by which pituitary stem cells contribute to tumourigenesis, which is different to the classical cancer stem cell paradigm (e.g. PMID:24094324; PMID:21636786;PMID:31699993).These stem cells become senescent and contribute to tumorigenesis though the synthesis and secretion of biologically active molecules, however the critical players have not yet been identified (e.g. PMID: 29180744; PMID: 29541918;; PMID: 33378554). Likewise, our models of low- and high- grade paediatric glioma provide an excellent platform to screen and test the effects of senolytics (e.g. PMID: 31799499; PMID: 30530705). The researcher will work in a team aiming to understand the molecular and cellular mechanisms underlying the development of craniopharyngioma and other paediatric brain tumours. http://iris.ucl.ac.uk/iris/browse/profile?upi=JPMAR49.

This post is funded until 31/03/2024 in the first instance.

Requirements:

-University degree (BSc/MSc/MRes) in relevant area, e.g. stem cell biology/ cell biology / developmental biology/ cancer biology

-PhD in relevant area either awarded or at least having gone through the PhD examination

-Experience of conducting research in mouse genetics, development and/or cancer

-Excellent knowledge of research lab techniques, including qRT-PCR, Tissue Culture, Immunohistochemistry and Histology among others.

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button above.

https://www.jobs.ac.uk/job/CGW940/research-fellow

Job Reference: 1876586
If you have any queries regarding the application process, please contact Khaled Islam on ich.hr@ucl.ac.uk quoting job reference.

Closing Date: 8/7/2021