Two PhD studentships in liver development and regeneration: live-imaging, spatial transcriptomics and cell biology of organ morphogenesis

The Ober group is looking for two talented and highly motivated PhD students in an exciting multidisciplinary project investigating the assembly of the intricate liver architecture in development and during repair using cutting-edge technologies.

We investigate the assembly of the hepatic tissue architecture and its cellular micro- environments in all its complexity in development and its restoration after injury. They offer a PhD project focusing on cell communication and ECM interactions driving cell polarity and hepatic tube formation during liver development and regeneration. The function of novel candidates, identified by comparative proteomics, will be examined by advanced imaging methods and state-of-the-art zebrafish genetics.

Information on the group, research topics and publications can be found on the laboratory website: https://www.entwbio.nat.fau.de/forschung/ag-prof-dr-elke-ober/

You will use zebrafish genetics, state-of-the-art cell molecular biology techniques (e.g. CRISPR/Cas9 genome editing, transgenesis), fluorescent in situ hybridization and immunohistochemistry, live– and fixed-tissue imaging methods combined with quantitative image analysis, statistical analysis, manuscript preparation.

You will receive a detailed education in molecular biology, zebrafish husbandry and genetics, fluorescence microscopy and computational image analysis.

The Division of Developmental Biology is a dynamic and collaborative research department, which is part of an interdisciplinary environment at FAU Erlangen-Nürnberg, Germany. Surrounding institutes provide an interactive scientific environment for development, cell biology and regeneration with all facilities essential for these ambitious research programmes.

Interested candidates should contact Elke Ober (elke.ober[at]fau.de) for further information, respectively. Please send your CV, research interests/letter of motivation, transcripts and contact information for two references. Applicants should have a MSc degree in the life sciences or related fields.

The positions will be available from November 2024, or upon agreement.