the community site for and by developmental biologists

Secret talk between epithelium and endothelium determines hair follicle stem cell fate

Posted by on November 6th, 2019

By Kefei Nina Li and Prachi Jain   Stem cells are typically defined by their ability to self-renew and differentiate. These activities are tightly controlled by both intrinsic cues and extrinsic cues from the microenvironment, known as the SC niche. This niche consists of multiple components, among which blood vessels (BVs) are critical as they[…]

October in preprints

Posted by on November 5th, 2019

Welcome to our monthly trawl for developmental biology (and related) preprints.  This month features a series of preprints on stem cell mechanics and tools to help you make organoids, some nectins and some nestins, plenty of auxin in our plant section, and some phantom crustaceans and macabre French genomics in our ‘Why Not’ section. They were[…]

Scientists identify new puberty-promoting genes

Posted by on November 5th, 2019

Press release from Development. You can also read the associated Research Highlight for this article. A team of neuroscientists led by Professor Christiana Ruhrberg (UCL, UK) and Professor Anna Cariboni (University of Milan, Italy) have found two molecules that work together to help set up the sense of smell and pave the way to puberty[…]

Pre-trained Machine Learning Models for Developmental Biology

Posted by on October 29th, 2019

Pre-trained Models for Developmental Biology Authors: Bradly Alicea, Richard Gordon, Abraham Kohrmann, Jesse Parent, Vinay Varma Our virtual discussion group (DevoWormML) has been exploring a number of topics related to the use of pre-trained models in machine learning (specifically deep learning). Pre-trained models such as GPT-2 [1], pix2pix [2], and OpenPose [3] are used for[…]

“My balance comes from instability” thought Herzog (Saul Bellow, Herzog)

Posted by on October 28th, 2019

A bit of background The dependence of a protein’s function on its structure is a well-known phenomenon. Back in 1970’s, it was suggested that most proteins would fold into one energetically stable or favorable conformational state in the cell determined by their primary amino acid sequence. This led to the notion of “one sequence to[…]

Starvation halts brain development, but hungry cells jump-start growth when food becomes available

Posted by on October 25th, 2019

In research that holds potential for prenatal health and brain injury, Scripps Research scientists identify cellular workings that stop and restart early brain development. Press release from Scripps Research, La Jolla.  We all know that food is essential to healthy development of the brain and body, especially in the earliest stages of life. But exactly[…]

Genetics Unzipped – When ‘Becky’ met Bateson: Edith Rebecca Saunders, the mother of British plant genetics

Posted by on October 24th, 2019

Unearthing the story of Edith Rebecca Saunders, the ‘mother of British plant genetics’.

A gnawing question: which cells are responsible for tooth renewal and regeneration?

Posted by on October 23rd, 2019

By Amnon Sharir (UCSF), Allon M Klein (HMS), Ophir D Klein (UCSF) As most mouse geneticists know, treating a rodent with malocclusion of its front teeth can be a Sisyphean task: as much as one trims the tooth, it grows right back within a few days (Figure 1). The basis of this often-frustrating situation is that[…]

Mammalian Genetics & Development Workshop – 30th anniversary!

Posted by on October 21st, 2019

A meeting of the Genetics Society  3rd December 2019 Venue: UCL Institute of Child Health, Guilford Street, London, WC1N 1EH Organisers: Nick Greene (UCL), Cynthia Andoniadou (KCL), Andy Copp (UCL) The Mammalian Genetics and Development Workshop is an annual meeting focusing on the development and genetics of mammals.  The Meeting is based on the submitted abstracts,[…]

Chromatin and epigenetics in development: a Special Issue

Posted by on October 15th, 2019

This editorial was recently published in Development and written by our editors Benoit Bruneau, Haruhiko Koseki, Susan Strome, Maria-Elena Torres-Padilla. Check out the Special Issue’s full table of contents here. The development of an organism is regulated by tightly coordinated changes in gene expression. From zygotic gene activation, through to lineage specification and organogenesis, and into[…]