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Displaying posts with the tag: embryo [Clear Filter]

Notch awakens: transitioning to the first differentiation step

Posted by on May 3rd, 2019

The story behind our recent paper in eLife.   In the mid-1900s, Conrad Hal Waddington introduced the idea of development as a series of branching decisions taken under the control of genes1. In mammals, the first of these decisions takes place before the implantation of the embryo in the maternal uterus and leads to the[…]

EmbryoPhenomics: An open-source technological platform

Posted by on February 5th, 2019

Tills O, Spicer JI, Grimmer A, Marini S, Jie VW, Tully E, Rundle SD. 2018. A high-throughput and open-source platform for embryo phenomics. PLOS Biology, 16:1-19. https://doi.org/10.1371/journal.pbio.3000074 Background A seasoned graduate student gave me some valuable advice at the outset of my PhD. She told me to FIND A BETTER WAY!  We were both working on[…]

Embryonic-Extraembryonic Interactions: from Genetics to Environment

Posted by on June 28th, 2018

The BSDB’s Autumn Meeting, to be held in Oxford this September, is the third in a series of international workshops on the extraembryonic-embryonic interface, bringing together researchers that address this topic through a wide array of approaches in diverse research organisms. This diversity of approaches is reflected by the organisers – Kat Hadjantonakis, Kristen Panfilio, Tristan Rodriguez, Susana Chuva[…]

New embryo phenotype data from the DMDD programme

Posted by on June 15th, 2018

Following our latest data release, the DMDD website (dmdd.org.uk) now contains detailed phenotype data for nearly 700 embryos from 82 different knockout mouse lines. Highlights include the identification of limb defects and cysts in Col4a2 knockouts and replication of the major features of Meckel syndrome in B9d2 knockouts. We have begun to add immunohistochemistry image[…]

PhD position: Single-cell elucidation of the evolution of an embryonic transcriptional programme

Posted by on April 3rd, 2018

The project: Single-cell approaches are revolutionizing developmental biology. We can now  trace in time the behavior of each cell in a live developing organism (1). In parallel, single-cell transcriptomics and genomics gives access to the transcriptional state of each cell (2). Combination of these two approaches promises to unravel how genomic information translates into individual[…]

PhD student position –  Max Planck Institute for Molecular Biomedicine

Posted by on December 15th, 2017

TheMax-Planck-Institute for Molecular Biomedicine in Muenster, Germany has an opening for a PhD student (position-code 15-2017). The position The position is available in the group of Dr. Ivan Bedzhov that is focused on understanding the self-organization of early mammalian embryos and stem cells. The successful candidate will investigate the mechanisms of spatiotemporal organization and cell fate transitions of[…]

Reactions to the CRISPR human embryo paper

Posted by on August 3rd, 2017

A paper published online yesterday in Nature (and ‘leaked’ a week ago by the MIT Technology Review) describes the use of CRISPR in human embryos to correct a mutation that causes hypertrophic cardiomyopathy. The work has hit the headlines and sparked debate about its utility and implications. Collated below are responses from the field (or[…]

9.5 million knockout mouse embryo images now available

Posted by on July 20th, 2017

A new set of DMDD embryo and placenta data has been released, taking our total dataset to 9.5 million images of around 1300 embryos. DMDD is a primary screen of embryonic lethal knockout mice, and all data can be freely accessed at dmdd.org.uk. Detailed phenotypes are available for embryos from 73 different knockout lines, and[…]

Why are geneticists measuring the webbing between mouse embryo fingers?

Posted by on February 21st, 2017

A new paper published in Journal of Anatomy shows that measuring the amount of inter-digital webbing in mouse embryos between 14 and 15 days gestation is the best way to find out their exact stage of development. So why is this important to a geneticist? If we want to discover a causal link between a gene[…]

Transposons in Embryo Space – TRACER maps in EMAGE

Posted by on February 9th, 2017

A recent publication in Developmental Biology by (Armit et al., 2017) describes how the TRACER dataset can be spatially compared with in situ hybridisation gene expression profiles.   The TRACER dataset of transposon-associated regulatory sensors (Chen et al., 2013) utilises Sleeping Beauty lacZ transposons that have been randomly integrated into the mouse genome Hundreds of[…]