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Off and On: it’s more complicated than we thought.

Posted by on January 23rd, 2020

We learn fairly early on when becoming biologists that both development and an organism’s response to environmental stressors require turning the right set of genes on in the right cells, at the right time. Clearly, for “on” to be meaningful, other genes have to be “off,” and many disordered conditions are associated with misexpression of[…]

Making time matter: how hormone pulses direct chromatin accessibility during development

Posted by on August 8th, 2017

Each of our cells has the same genetic information and thus the same potential to become a part of a heart, brain, or a finger. Somehow though, during development our cells manage to figure out exactly which type of cell they should be and which body parts they should help compose. The key to making[…]