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WormBase: It’s not just for C. elegans anymore

Posted by on October 29th, 2010

WormBase — wormbase.org — is the central data repository for Caenorhabditis elegans and related nematodes. C. elegans is a well-known system for studying problems in developmental biology, the benefits of which I will quickly rehash here. Its rapid generation time from fertilized egg to gravid adult (3.5 days) and small size (1mM) permit 1000’s of[…]

Pleiades Promoter Project

Posted by on September 27th, 2010

A recent paper in PNAS describes the development of MiniPromoters: human DNA promoters of less than 4 kb, designed to drive gene expression in specific areas of the brain. The initiative is called the Pleiades Promoter Project, and so far they have confirmed brain-region specific activity in knockin mice for 27 of their MiniPromoters. The[…]