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Natural Pluripotency vs. Artificial Pluripotency

Posted by on January 20th, 2016

Pluripotency is the developmental potential of cells to become various types of mature cells in the body. During development, a pluripotent embryo progressively differentiates to give rise to mature cell types in the organism that form major organs such as the brain, heart, and kidneys. The transient nature of pluripotent cells, however, also makes it[…]

From our sister journals- November 2015

Posted by on November 30th, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.     Genome-wide lacZ profiling in the mouse Tuck, Estebel and colleagues have produced an open access adult mouse expression resource with the expression profile of 424 assessed in up to 47 different organs, tissues and substructures using a[…]

From our sister journals- September 2015

Posted by on September 28th, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.             Auditory hair cell defects in Wolf-Hirschhorn syndrome Wolf-Hirschhorn syndrome (WHS) is a rare genetic disorder associated with sensorineural deafness. In this study, Andrea Streit and colleagues show that, although cochlear hair cells are specified[…]

Finding Collaborators: from London to Stuttgart

Posted by on May 28th, 2015

I’m Dr Rie Saba, a postdoc at Translational Cardiovascular Therapeutics, William Harvey Research Institute, Queen Mary University of London (UK), studying the role of endocardium in the mammalian heart development. The endocardium contributes to cardiogenesis by playing many crucial roles, such as regulating trabeculation and atrioventricular canal formation. However, our knowledge of the early phase[…]

iPS cell culture scientist in the Scottish Centre for Regenerative Medicine

Posted by on July 13th, 2012

Job Summary: Due to the set up of a new induced pluripotent stem (iPS) cell facility managed by Roslin Cells Ltd, we are looking to employ two Cell Culture Scientists to work within a small team engaged in the generation of new research grade and clinical grade cell lines for academic and commercial customers. Job Description: The post[…]

Senescent cell rejuvenation – you(r cells) are never too old for pluripotency!

Posted by on December 3rd, 2011

  In 2007, a group let by Takahashi and Yamanaka from Kyoto University successfully generated pluripotent cells from human adult fibroblasts.  They were able to induce a pluripotent state in differentiated cells by introducing four transcription factors, OCT4, SOX2, c-MYC, and KLF4 by retroviral infection, hence the name “induced pluripotent stem cells (iPSCs).”  Although the[…]

iPSC timeline

Posted by on March 3rd, 2011

Update 23/09/19: Please note that the below piece links to Dipity, a now defunct website. Over at the Drop In Blog you can read the story of what happened to the site.    Science writer Ed Yong put together an interactive timeline of breakthroughs in the field of induced pluripotent stem cells (iPSC), inspired by[…]