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Pairing of segmentation clock genes results in robust pattern formation

Posted by on February 4th, 2021

By Oriana Q. H. Zinani, Kemal Keseroğlu, Ahmet Ay & Ertuğrul M. Özbudak: Gene expression is an inevitably stochastic process (Ozbudak et al., 2002). In contrast, embryonic development and homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes. Many mechanisms are known to orchestrate this coordination, such as operons, bidirectional promoters,[…]

PhD in Systems Biology of Embryoid Self-Organization (Seville, Spain)

Posted by on July 17th, 2019

4 year PhD position, Seville Spain (deadline 25/07/19) We are looking for students with a Master degree to join our lab for a 4 year PhD position, application deadline 25/07/19. Our laboratory investigates fundamental questions of developmental biology by using mouse embryonic stem cells spheroids known as Embryoids. The successful candidate will develop a project[…]

Postdoctoral Training Fellow – Quantitative Biology

Posted by on September 27th, 2017

SUMMARY   An exciting interdisciplinary opportunity has come up in the newly established Quantitative Cell Biology laboratory headed by Dr Silvia Santos. We are seeking a creative, highly motivated postdoc with a strong quantitative background, who enjoys working in a collaborative research environment, to investigate how cells decode signals and irreversibly commit to different cell[…]

Towards a synthetic embryo

Posted by on September 24th, 2014

Waddington, whose writings on the epigenetic landscape continue to influence developmental biology to this day, called the developing embryo “the most intriguing object that nature has to offer”(Waddington, 1966). The mechanisms of pattern formation and morphogenesis have fascinated biologists for centuries. One question that is difficult to answer is what are the minimal requirements for[…]

What does a cell know and how does it know it (Just a thought on Dennis Bray’s Wetware, Yale University Press) Alfonso Martinez Arias (Dpt Genetics, University of Cambridge, Cambridge UK. ama11@hermes.cam.ac.uk)

Posted by on May 10th, 2012

It is a time of gene counting, mapping, function guessing in a narrow way: a gene for this or a gene for that. If one reads the indexes of journals one might believe that by adding genes one gets an organism. It is for this reason that reading a book like “Wetware” by Dennis Bray[…]

Phenologs and unlikely models

Posted by on September 1st, 2010

“You’re probably wondering why I’m here”, were the first words of Edward Marcotte’s talk at the SDB meeting last month. After all, he was about to speak about systems biology in a session on organogenesis. What followed was not only a new way to identify genes involved in developmental processes, but also a perfect example[…]