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The story of my heart, from the bottom of my heart (says the Zebrafish)

Posted by on June 23rd, 2020

I started off as quite little—just one cell, in fact. No heart, no brain, no blood flowed in me and yet, somehow I found the motivation in me to divide. One me made two and two mes made four, till many tiny mes made me a full-fledged embryo with a heart full of hope. As[…]

Stripe by stripe, zebrafish model provides transparent look into Fibrolamellar Carcinoma mechanism

Posted by on June 3rd, 2020

This post highlights the approach and finding of a new research article published by Disease Models and Mechanisms (DMM). This feature is written by Joseph I. Kaluzny as apart of a seminar at The University of Alabama (taught by DMM Editorial Board member, Prof. Guy Caldwell) on current topics related to use of animal and[…]

Cilia, Reissner Fiber and Crooked Spines

Posted by on May 18th, 2020

Perhaps the most exciting aspect of attending any scientific meeting is the privilege of becoming aware of novel research findings in our fields of interest, prior to their appearance in published literature – and this begins as soon as we have the abstract book in hand! Sitting in my hotel room in Suzhou, and browsing[…]

Research Technician position investigating the mechanisms underlying cardiac development and disease

Posted by on April 16th, 2020

The Bloomekatz laboratory in the Department of Biology at the University of Mississippi in Oxford, MS is seeking a research technician to assist in our investigations of cardiac morphogenesis and disease using zebrafish. We utilize an innovative combination of genetic, live-imaging, biophysical and system-biology approaches to elucidate the mechanisms underlying morphogenetic and identity transformations in[…]

Kink in the road: the notochord’s role in spine formation and scoliosis

Posted by on April 14th, 2020

By Jennifer Bagwell and Michel Bagnat   Our lab investigates the role of hydrostatic pressure as a morphogenetic force using zebrafish as a model system.  This work was originally focused on tube formation and had revealed a crucial role for fluid secretion in single lumen formation (Navis and Bagnat, 2015). When I joined, the lab[…]

BSDB Gurdon/The Company of Biologists 2019 Summer Studentship Report – Isabel Swinburn

Posted by on January 16th, 2020

Established by the British Society for Developmental Biology in 2014, The Gurdon/The Company of Biologists Summer Studentship scheme provides financial support to allow highly motivated undergraduate students an opportunity to engage in practical research during their summer vacation. Each year, ten successful applicants spend eight weeks in the research laboratories of their choices, and the feedback[…]

Postdoctoral positions in Neurobiology

Posted by on November 12th, 2019

The Poulain lab (www.poulainlab.org) at the University of South Carolina in Columbia, SC seeks talented and motivated postdocs! We use zebrafish as a vertebrate model system and a unique combination of genetic, embryological and live imaging approaches to study the cellular and molecular mechanisms of axon guidance and degeneration during the formation of neural circuits in vivo.[…]

Down from the crest to clear the dead

Posted by on September 30th, 2019

Yunlu Zhu & Sarah Kucenas   Introduction Cells are the building blocks of life. However, in multi-cellular organisms, millions of cells are subject to death due to injury, infection and ordinary cell turnover (Galluzzi et al., 2018). For example, epithelial cells in the small intestine rapidly renew every 2 to 6 days in most mammals,[…]

Moving in concert: How lateral line primordium cells coordinate to migrate

Posted by on September 21st, 2019

Written by Tugba Colak-Champollion Story behind our recent paper in Current Biology “Cadherin-Mediated Cell Coupling Coordinates Chemokine Sensing across Collectively Migrating Cells” (Tugba Colak-Champollion, Ling Lan, Alisha R. Jadhav, Naoya Yamaguchi, Gayatri Venkiteswaran, Heta Patel, Michael Cammer, Martin Meier-Schellersheim, Holger Knaut)   Guided cell migration is a crucial event in many biological and mechanical processes.[…]

Beyond morphogen signaling

Posted by on June 25th, 2019

By Dörthe Jülich & Scott Holley   Organizers pattern surrounding tissues via secreted morphogens that specify different cell states as a function of concentration. Wolpert’s French Flag model is commonly used to describe how morphogen gradients specify different fates. Our recent study integrates tail organizer signaling with control of morphogenesis during vertebrate body elongation (Das,[…]