The Hippo pathway in development and disease

The Harvey Laboratory is looking to employ motivated and talented postdoctoral fellows to study the role of the Hippo pathway in organ size control and cancer. Our research is situated at both the Peter MacCallum Cancer Centre and Monash University in Melbourne, Australia.

We employ a range of techniques including Drosophila genetics, advanced microscopy, transcriptomics, bioinformatics, molecular biology and cancer cell biology. You will work in a supportive team, be a good communicator and also have the ability to work independently. You will possess expertise in a range of molecular and cell biology, biochemical and genetic techniques. Experience in Drosophila genetics is advantageous but not essential.

Peter MacCallum Cancer Centre is Australia’s largest specialist cancer centre with 600 research staff and students. We are located in Australia’s largest and most vibrant biomedical precinct with more than 10,000 researchers across multiple Universities, Research Institutes and Hospitals. Melbourne is a multi-cultural city with great food, weather, culture and sport and is often voted the world’s most liveable city.

For more information visit this link: https://www.petermac.org/research/labs/kieran-harvey

or email Prof Kieran Harvey (kieran.harvey@petermac.org):

Selected References:

1. Poon et al., (2018). A Hippo-like signaling pathway controls tracheal morphogenesis in Drosophila melanogaster.Developmental Cell.47: 564-575.

2. Manning et al., (2018). Dynamic fluctuations in subcellular localization of the Hippo pathway effector Yorkie in vivo.Current Biology.28: 1651-1660.

3. Degoutin et al., (2013).Riquiqui and Minibrain, regulators of the Hippo pathway downstream of Dachsous.Nature Cell Biology.15: 1176-1185.

4. Harvey et al., (2013). The Hippo pathway and human cancer. Nature Reviews Cancer.13: 246-257.

5. Poon, et al.,(2011). The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Developmental Cell.21: 896-906.

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