Transcriptional Regulation of Stem Cell Fate-Postdoctoral position, Philpott Lab

Department/Location: Wellcome Trust-Medical Research Council Stem Cell Institute

Salary: £32,816-£40,322

Reference: PS21993

Category: Research

Published: 6^th January, Closing date: 5^th February 2020

A postdoctoral Research Associate position is currently available for an individual to work in the laboratory of Prof. Anna Philpott within the Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/research/pis/philpott). The Philpott lab has broad interests in understanding the fundamental mechanisms that determine cell fate choice and differentiation during embryonic development and in cancers, as well as how these processes are co-ordinated with cell cycle progression.

The successful candidate will undertake a project focused around transcriptional regulation of lineage fidelity during fate specification and differentiation of mouse embryonic stem cells, focusing on uncovering epigenetic and co-factor-dependent mechanisms underlying these processes. There is also an opportunity to work on parallel mechanisms of fate specification and differentiation in Xenopus embryos.  Within the laboratory, we use several experimental systems including mammalian embryonic stem cells, cancer cell culture, organoid systems as well as embryos of the frog Xenopus laevis. We use many techniques including genome-wide analysis of gene expression in single and multiple cells, chromatin binding and accessibility studies and crispr genome editing, alongside diverse biochemical approaches.

The successful candidate will have a PhD, considerable experience in stem cell biology, epigenetics, molecular biology, developmental biology, or a similar field, and a proven track record in scientific publication. Prior experience in mammalian cell culture is essential. Experience of epigenetics and/or transcriptional regulation are essential, while experience of genome-wide transcriptional analysis, and in particular analysis at the single cell level, would also be an advantage. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have good presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers.

The Wellcome – MRC Cambridge Stem Cell Institute (CSCI) is a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology. https://www.stemcells.cam.ac.uk/ . CSCI moved to the brand new, state of the art Jeffrey Cheah Biomedical Centre building on the Cambridge Biomedical Campus in summer 2019. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

Application via: http://www.jobs.cam.ac.uk/job/24656/

Informal enquiries should be directed to Prof. Anna Philpott, ap113@cam.ac.uk

Fixed-term: The funds for this post are available for 3 years in the first instance.

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