the community site for and by
developmental and stem cell biologists

Asymmetric Cell Division – PhD and Postdoc position available

Posted by , on 2 April 2013

Closing Date: 15 March 2021

banner for node

 

 

 

Asymmetric cell division of neural stem cells

Funding for a PhD and a postdoc position is immediately available in the lab of Jens Januschke at the College of Life Sciences (University of Dundee, UK) to study asymmetric cell division in Drosophila. The projects address how stem cells produce two daughter cells with different fates through a single division. The basic aims are to mechanistically dissect how polarity of stem cells and cell fate choice are linked using genetics and state-of-the-art live imaging as well as OMX super resolution microscopy.

Asymmetric cell division is of critical importance for development and normal tissue maintenance. We use Drosophila neural stem cells, called neuroblasts, as a model to identify the mechanisms that underpin this fundamental process. Defective cell fate choice is implicated in many diseases particularly cancer. Neuroblasts offer the exciting possibility to study the mechanisms that govern cell fate choices in living stem cells and document and measure their activity over time.

If you are interested in the project, want to deepen your background in cell and developmental biology and have a high interest in microscopy please contact us.  Applicants should have a strong background in cell or developmental biology. Experience in quantitative image analysis and previous experience with Drosophila are advantageous. Please provide  a short letter of motivation, CV and the email addresses of three references. Funding for specialised training courses in microscopy is also available.

 

References

Januschke, J. et al. Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts. Nature cell biology 15, 241-248,(2013).

Januschke, J., Llamazares, S., Reina, J. & Gonzalez, C. Drosophila neuroblasts retain the daughter centrosome. Nature communications 2, 243,(2011).

Januschke, J. & Gonzalez, C. Drosophila asymmetric division, polarity and cancer. Oncogene 27, 6994-7002,(2008).

 

http://www.lifesci.dundee.ac.uk/people/jens-januschke-1

http://www.lifesci.dundee.ac.uk/research/cdb/

http://www.dundee.ac.uk/main/colleges-services/

http://microscopy.lifesci.dundee.ac.uk/index.html

Thumbs up (No Ratings Yet)
Loading...

Tags: , , , ,
Categories: Jobs

Leave a Reply

Your email address will not be published. Required fields are marked *

Get involved

Create an account or log in to post your story on the Node.

Sign up for emails

Subscribe to our mailing lists.

Do you have any news to share?

Our ‘Developing news’ posts celebrate the various achievements of the people in the developmental and stem cell biology community. Let us know if you would like to share some news.