Asymmetric cell division of neural stem cells
Funding for a PhD and a postdoc position is immediately available in the lab of Jens Januschke at the College of Life Sciences (University of Dundee, UK) to study asymmetric cell division in Drosophila. The projects address how stem cells produce two daughter cells with different fates through a single division. The basic aims are to mechanistically dissect how polarity of stem cells and cell fate choice are linked using genetics and state-of-the-art live imaging as well as OMX super resolution microscopy.
Asymmetric cell division is of critical importance for development and normal tissue maintenance. We use Drosophila neural stem cells, called neuroblasts, as a model to identify the mechanisms that underpin this fundamental process. Defective cell fate choice is implicated in many diseases particularly cancer. Neuroblasts offer the exciting possibility to study the mechanisms that govern cell fate choices in living stem cells and document and measure their activity over time.
If you are interested in the project, want to deepen your background in cell and developmental biology and have a high interest in microscopy please contact us. Applicants should have a strong background in cell or developmental biology. Experience in quantitative image analysis and previous experience with Drosophila are advantageous. Please provide a short letter of motivation, CV and the email addresses of three references. Funding for specialised training courses in microscopy is also available.
Januschke, J. et al. Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts. Nature cell biology 15, 241-248,(2013).
Januschke, J., Llamazares, S., Reina, J. & Gonzalez, C. Drosophila neuroblasts retain the daughter centrosome. Nature communications 2, 243,(2011).
Januschke, J. & Gonzalez, C. Drosophila asymmetric division, polarity and cancer. Oncogene 27, 6994-7002,(2008).