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Reproducibility: a pathological perspective

Posted by on June 20th, 2016

” the ability to reproduce experimental findings remains essential for the forward movement of science and the application of laboratory findings to the clinic”   This is an extract from a Special Article article that originally appeared in Disease Models and Mechanisms (available here Open Access) Paul Schofield, Jerrold Ward, John P. Sundberg   Reproducibility of data from[…]

Question of the month – the 14 day rule for human embryo research

Posted by on May 31st, 2016

Earlier this month, two papers were published (from the Brivanlou and Zernicka-Goetz labs) that reported in vitro systems to study development of the human embryo through implantation stages. These experiments have kept human embryos developing for longer than any previous work, and close in on the 14-day limit imposed by many governmental and regulatory bodies.[…]

Fueling embryology and developing metabolism

Posted by on May 25th, 2016

By Carlos Carmona-Fontaine and Patricia Nunes   Most scientific conferences have become large gatherings where little exchange of ideas can actually occur. There are way too many people to start socializing with folks you don’t know and there are so many talks that the idea of sitting through one on a topic on which you[…]

Desiccated embryos at the piano

Posted by on May 12th, 2016

A few weeks ago, as I listened to Classic FM while trying to finish some of my projects on the Node, I came across a piano composition by Erik Satie called ’embryons desséchés’, the dessicated embryos. At the time I was too busy but now that I have a bit more time I tried to[…]

Question of the month- Ethical issues in life sciences publishing

Posted by on April 28th, 2016

In the last few years, the life sciences have been plagued by cases of scientific misconduct which led to corrections,  retractions and, to some extent, in a lack of trust on the scientific record. This has encompassed a variety of issues, from  manipulation to fabrication of data, from inappropriate use of statistics (unintentional or otherwise) to[…]

Scratching the surface of a rainbow

Posted by on April 26th, 2016

  Why some vertebrates like salamanders and zebrafish are able to regenerate complex tissues while humans cannot is a question that has fascinated biologists for centuries. Understanding how and why regeneration occurs in these animals can inspire novel treatment strategies for regenerative medicine. At the cellular level, the regeneration process is driven by dynamic activities[…]

Mole’s Wow! So now you have your own lab! Part IX – The big fight

Posted by on April 20th, 2016

This cartoon was first published in the Journal of Cell Science. Read other articles and cartoons of Mole & Friends here.     Part I- ‘The imposter’ Part II- ‘The teaching monster’ Part III- ‘The Pact’ Part IV- ‘The fit’ Part V- ‘The plan’ Part VI- ‘FCTWAWKI’ Part VII- ‘Beaten and bruised’ Part VIII- ‘Money Matters’ (+1[…]

Question of the month- brain organoids

Posted by on March 21st, 2016

Last week, Development announced a special issue on organoids. In vitro organogenesis is a burgeoning new field, with applications in the study of human development, drug testing and ultimately the possibility of producing functional organs in the dish that could be used for transplantation. Every new technological advance brings with it a new set of ethical issues, and[…]

Editorial- Closing the circle: from organoids back to development

Posted by on March 15th, 2016

This editorial was written by Melissa Little and first appeared in Development.   Organogenesis is an inherently fascinating developmental process. It requires the creation of complex form and function from a collection of distinct cell types, all of which come together without a template. To achieve this, cells within the developing organ undergo differentiation, migration,[…]

What would you ask Nobel Prize Laureate Shinya Yamanaka?

Posted by on March 14th, 2016

It’s been 10 years since induced pluripotent stem cells (iPSCs) were first reported from the lab of Prof. Shinya Yamanaka. Since then, the field of direct reprogramming has grown immensely, and iPSCs have proved themselves to be an extremely useful and versatile tool, enabling research into basic developmental biology, the mechanism of reprogramming itself, as[…]