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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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What’s your favourite gene?
Posted by Lilian Hunt on April 11th, 2014
I recently took part in the ‘I’m a scientist, get me out of here!’ outreach event. As soon as the school children found out I was a developmental geneticist and worked out what I did, one question I was repeatedly asked was: “what’s your favourite gene and why?” so for a bit of fun, I […]
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Mapping the Embryo for Developmental Biologists & Stem Cell Researchers; LifeMap Discovery® – a Roadmap of Mammalian Cell Ontology
Posted by arielrinon on March 30th, 2014
Understanding how cells differentiate during embryonic development is invaluable for the in vitro derivation of functional cells from stem cells. However, mapping the human embryo, including characterization of all the cell types that make up the developing and mature human body, and of all embryonic progenitor cell types that appear in intermediate developmental stages, is […]
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Negative findings: tackling the negativity
Posted by Paraminder Dhillon on March 18th, 2014
‘Science is often romanticised as a flawless system of knowledge building, where scientists work together to systematically find answers. In reality, this is not always the case. Dissemination of results are straightforward when the findings are positive, but what happens when you obtain results that support the null hypothesis, or do not fit with the […]
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Cellularization in Drosophila, University of Chicago Journal Club
Posted by UChicagoDRSB_JC on March 15th, 2014
Cellularization in Drosophila embryos is quite the remarkable process. After fertilization, nuclear division occurs rapidly but without cell membrane formation, leading to a syncytial embryo with many nuclei in a common cytoplasm. After 9 mitotic divisions, the nuclei begin migration to the periphery of the syncytium, such that nuclei line the plasma membrane of the […]
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In time of revision: of Wingless and morphogens
Posted by ama on December 27th, 2013
In time of revision: of Wingless and morphogens Alfonso Martinez Arias The recent publication of the important work of C. Alexandre, LA. Baena and JP. Vincent on the molecular requirements for Wingless signalling in Drosophila (http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12879.html) offers an opportunity to consider the relationship between ideas and facts in modern developmental biology. The work reports the […]
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Setting the record straight- an interview with Daniel St Johnston
Posted by the Node on December 3rd, 2013
Professor Daniel St Johnston is a prominent developmental biologist and the current director of the Gurdon Institute in Cambridge (UK). The St Johnston lab recently retracted two papers, in what Retraction Watch lauded as a poster case of ‘doing the right thing’. The Node interviewed Daniel and discussed the case, and how his experience highlighted […]
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Conflicts of Interest
Posted by Thomas Butts on October 28th, 2013
‘‘None of the scientists would comment on the record, for fear that it would affect their funding or that of their postdocs and graduate students’’ Nature, September 2012 ‘Is science wrong?’ The Economist, frontcover October 2013 A Disclaimer I have been very fortunate to come across senior scientists in my career who do not […]
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Evolution of the Human Neocortex: How Unique Are We?
Posted by Alexandra de Sousa on October 28th, 2013
“Evolution of the Human Neocortex: How Unique Are We?” was the question asked at the Wiston House in West Sussex from 22-25 September 2013. Although we were hardly the first to consider whether the human brain is something special, the ‘unique’ pileup of methodological approaches likely improved the dialogue on this topic. My own presentation sought […]
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Neocortex evolution and human uniqueness
Posted by SteveBriscoe on October 20th, 2013
“So God created mankind in his own image, in the image of God he created them; male and female he created them. God blessed them and said to them, ‘Be fruitful and increase in number; fill the earth and subdue it. Rule over the fish in the sea and the birds in the sky and over every living creature that moves on the […]
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Cellular Reincarnation
Posted by Ewart Kuijk on October 1st, 2013
Stuck! Here I was trapped in this valley with no way out. And it was crowded here, with all of my fibers I sensed numerous peers condemned to a similar fate. The wonderful scenes that could be reached from the top of Mt. Waddington had been illusionary. Was this my reward: being trapped in Fibrocity, […]
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- Spine-tingling new role for Sall4 [IN THIS ISSUE]
- Ageing thymus out-FOXed [IN THIS ISSUE]
- Muscling in on stem cell hierarchy [IN THIS ISSUE]
- Nucleolus precursor body makeover [IN THIS ISSUE]
- Moss stem cells do it differently [IN THIS ISSUE]
- Change of heart for RA signalling [IN THIS ISSUE]
- The evolution and conservation of left-right patterning mechanisms [HYPOTHESIS]
- The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease [REVIEW]
- Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus [RESEARCH ARTICLES]
- The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition [RESEARCH ARTICLES]
- The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis [RESEARCH ARTICLES]
- Development of five digits is controlled by a bipartite long-range cis-regulator [RESEARCH ARTICLES]
- Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord [RESEARCH ARTICLES]
- Type I TARPs promote dendritic growth of early postnatal neocortical pyramidal cells in organotypic cultures [RESEARCH ARTICLES]
- Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination [RESEARCH ARTICLES]
- Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis [RESEARCH ARTICLES]
- A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication [RESEARCH ARTICLES]
- Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock [RESEARCH ARTICLES]
- Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems [Articles of interest in other COB journals]
- Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours [Articles of interest in other COB journals]
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- Editorial Board
- Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers
- Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression
- Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish
- Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells
- Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear
- Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development
- Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta
- Editorial Board
- Do the BEAF insulator proteins regulate genes involved in cell polarity and neoplastic growth?
- Lhx1 is required in Müllerian duct epithelium for uterine development
- A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans
- Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis
- Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads
- CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways
- The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis
- Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones
- Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages
- Editorial Board
- Development and evolution of vertebrate cranial placodes
- Setting appropriate boundaries: Fate, patterning and competence at the neural plate border
- Establishing the pre-placodal region and breaking it into placodes with distinct identities
- Neural crest and placode interaction during the development of the cranial sensory system
- Signaling mechanisms controlling cranial placode neurogenesis and delamination
- Sensational placodes: Neurogenesis in the otic and olfactory systems
- The development of lateral line placodes: Taking a broader view
- The evolutionary history of vertebrate cranial placodes – I: Cell type evolution
- The evolutionary history of vertebrate cranial placodes II. Evolution of ectodermal patterning
- Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis
- Editorial Board
- Impact
- Why you should publish your papers in Developmental Biology
- SDB 2014 Meeting Announcement
- Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death
- Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis
- Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis
- Epigenetic regulation of oogenesis and germ stem cell maintenance by the Drosophila histone methyltransferase Eggless/dSetDB1
- Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development
- The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera
- Retraction notice to “The human placenta is a hematopoietic organ during the embryonic and fetal periods of development” [Dev. Biol. 327 (2009) 24–33]
- Ecdysone differentially regulates metamorphic timing relative to 20-hydroxyecdysone by antagonizing juvenile hormone in Drosophila melanogaster
- Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney
- Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice
- Cell signaling during development of Dictyostelium
- Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear
- Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning
- The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans
- Neuroblast lineage identification and lineage-specific Hox gene action during postembryonic development of the subesophageal ganglion in the Drosophila central brain
- miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells
- Editorial Board
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- Dystrophic muscle environment induces changes in cell plasticity [Perspectives]
- DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos [Reviews]
- The diabetes gene Hhex maintains {delta}-cell differentiation and islet function [Research Communications]
- Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e [Research Communications]
- HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles [Research Papers]
- miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF{beta} and Wnt signaling [Research Papers]
- ATR checkpoint kinase and CRL1{beta}TRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks [Research Papers]
- Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression [Research Papers]
- Distinct regulatory mechanisms balance DegP proteolysis to maintain cellular fitness during heat stress [Research Papers]
- Root growth is modulated by differential hormonal sensitivity in neighboring cells [Research Papers]
- Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin [Errata]
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