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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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Reaching out – the many faces of science outreach
Posted by the Node on January 20th, 2015
This Spotlight was first published in Development. The days of the solitary scientist toiling away within the isolation of the academic ivory tower are something of the past. This is not only true when actually doing science, as projects become more collaborative and global, but also when considering the relationship between scientists and the public. Science outreach is something that most […]
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From naïve pluripotency to chimeras: a new ethical challenge?
Posted by the Node on December 18th, 2014
This article by Insoo Hyun was first published in Development. Also read the companion ethics article here. In recent years, there has been much interest in the prospect of generating and using human stem cells that exhibit a state of naïve pluripotency. Such a pluripotent state might be functionally confirmed by assessing the chimeric contribution of these cells to non-human blastocysts. Furthermore, the […]
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Ethical considerations in chimera research
Posted by the Node on December 18th, 2014
This article by Göran Hermerén was first published in Development. Also read the companion ethics article here. The development of human pluripotent stem cells has opened up the possibility to analyse the function of human cells and tissues in animal hosts, thus generating chimeras. Although such lines of research have great potential for both basic and translational science, they […]
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Looking inwards: opening a window onto human development
Posted by the Node on December 16th, 2014
This editorial was first published in Development. It was written by Olivier Pourquié, Benoit Bruneau, Gordon Keller and Austin Smith. The past 30 years or so have witnessed tremendous advances in the field of developmental biology. This has resulted in a growing (although still incomplete) understanding of the molecular basis of embryonic development, including characterization of signals and genes involved […]
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The Future of Research Symposium:
The Funding of Research
Posted by Gary McDowell on October 1st, 2014
This is the last of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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The Future of Research Symposium:
Metrics: The Folly of Hoping for X whilst Rewarding Y
Posted by Gary McDowell on September 29th, 2014
This is the third of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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The Future of Research Symposium:
The Structure of the Workforce
Posted by Gary McDowell on September 25th, 2014
This is the second of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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The Future of Research Symposium:
How Scientists are Trained
Posted by Gary McDowell on September 23rd, 2014
This is the first of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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What is your favourite conference venue?
Posted by Cat Vicente on September 10th, 2014
Last month I was lucky enough to attend the Xenopus meeting, which took place at the Asilomar conference grounds, close to Monterey, California. This meeting was fantastic, combining great science with a great venue. As there is already someone lined up to write about the scientific aspects of the meeting, I thought I would focus here instead on the […]
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Ethical development
Posted by Katherine Brown on September 2nd, 2014
This editorial was first published in Development. We encourage feedback from the community on our policies – please leave any comments below. A central premise of scientific publishing – that publication in a peer-reviewed journal means that the reader can be confident that an article is solid – has been challenged on a number of fronts in recent times. […]
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- Invadosomes: aiding axonal invasion [IN THIS ISSUE]
- Taking the strain out of stem cell renewal [IN THIS ISSUE]
- Reporting on {beta}-catenin in the vasculature [IN THIS ISSUE]
- PUB4 calls time on root cell division [IN THIS ISSUE]
- Reaching out - the many faces of science outreach [SPOTLIGHT]
- Mathematically guided approaches to distinguish models of periodic patterning [HYPOTHESIS]
- Building a plant: cell fate specification in the early Arabidopsis embryo [REVIEW]
- Regulation of ECM degradation and axon guidance by growth cone invadosomes [RESEARCH ARTICLES]
- {beta}-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels [RESEARCH ARTICLES]
- DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos [RESEARCH ARTICLES]
- ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination [RESEARCH ARTICLES]
- A transient wave of BMP signaling in the retina is necessary for Muller glial differentiation [RESEARCH ARTICLES]
- Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration [RESEARCH ARTICLES]
- Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea [RESEARCH ARTICLES]
- A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face [RESEARCH ARTICLES]
- SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice [RESEARCH ARTICLES]
- Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7 [Articles of interest in other COB journals]
- The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4 [Articles of interest in other COB journals]
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- Editorial Board
- From classical to current: Analyzing peripheral nervous system and spinal cord lineage and fate
- Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition
- Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis
- Ecdysone regulates morphogenesis and function of malpighian tubules in Drosophila melanogaster through EcR-B2 isoform
- Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development
- Effects of polysialic acid on sensory innervation of the cornea
- Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers
- Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during drosophila hematopoiesis
- Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development
- Foxp1/2/4 regulate endochondral ossification as a suppresser complex
- C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting
- E3 ubiquitin ligases promote progression of differentiation during C. elegans embryogenesis
- Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation
- Editorial Board
- Differential pleiotropy and HOX functional organization
- A method for using direct injection of plasmid DNA to study cis-regulatory element activity in F0 Xenopus embryos and tadpoles
- Developmental alterations of the C. elegans male anal depressor morphology and function require sex-specific cell autonomous and cell non-autonomous interactions
- PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans
- Mechanics of blastopore closure during amphibian gastrulation
- CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila melanogaster
- Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT
- Nf2–Yap signaling controls the expansion of DRG progenitors and glia during DRG development
- Three-dimensional cultures of trophoblast stem cells autonomously develop vascular-like spaces lined by trophoblast giant cells
- Molecular characterization of the apical organ of the anthozoan Nematostella vectensis
- Juvenile skeletogenesis in anciently diverged sea urchin clades
- Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors
- Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2
- BMP-Smad4 signaling Is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse
- Hedgehog signaling in prostate epithelial-mesenchymal growth regulation
- C. elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response
- Znf385C mediates a novel p53-dependent transcriptional switch to control timing of facial qbone formation
- Fgf10 is required for specification of non-sensory regions of the cochlear epithelium
- Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila
- Pluripotent stem cell derived cardiovascular progenitors – A developmental perspective
- Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development
- Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms
- RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs
- The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration
- Loss of function of the yellow-e gene causes dehydration-induced mortality of adult Tribolium castaneum
- Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans
- microRNAs regulate β-catenin of the Wnt signaling pathway in early sea urchin development
- Ontogeny of the mouse vocal fold epithelium
- Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration
- The organizer in evolution–gastrulation and organizer gene expression highlight the importance of brachyury during development of the coral, Acropora millepora
- Editorial Board
- The BED finger domain protein MIG-39 halts migration of distal tip cells in Caenorhabditis elegans
- Pox neuro control of cell lineages that give rise to larval poly-innervated external sensory organs in Drosophila
- Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development
- Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development
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- From equator to pole: splitting chromosomes in mitosis and meiosis [Reviews]
- A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation [Research Communications]
- The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells [Research Papers]
- Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2 [Research Papers]
- Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth [Research Papers]
- ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis [Research Papers]
- FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation [Research Papers]
- Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination [Research Papers]
- Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly [Research Papers]
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- Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State
- Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion
- A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division
- Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling
- Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions
- Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity
- Salvador-Warts-Hippo Pathway in a Developmental Checkpoint Monitoring Helix-Loop-Helix Proteins
- Phosphorylation of Cohesin Rec11/SA3 by Casein Kinase 1 Promotes Homologous Recombination by Assembling the Meiotic Chromosome Axis
- Hypo- or Hyper-Hippo: A Balancing Act with bHLH Transcription Factors
- Enhancer Trafficking: Free Throws and Three-Pointers
- Sequential Contraction and Exchange of Apical Junctions Drives Zippering and Neural Tube Closure in a Simple Chordate
- Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins
- Functional Reprogramming of Polyploidization in Megakaryocytes
- The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression
- Casein Kinase 1 Promotes Initiation of Clathrin-Mediated Endocytosis
