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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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Flippase recognition target: orientation matters, so why care?
Posted by Mario Metzler on April 16th, 2014
FRT sites are used often (at least in Drosophila) for inducing deletions or “flipping out” of markers in transgenic constructs. When there are two FRTs sequences in tandem, after inducing flippase the DNA sequence that is between these two sites will be deleted. If two FRT sites are facing each other (or looking away), the […]
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What’s your favourite gene?
Posted by Lilian Hunt on April 11th, 2014
I recently took part in the ‘I’m a scientist, get me out of here!’ outreach event. As soon as the school children found out I was a developmental geneticist and worked out what I did, one question I was repeatedly asked was: “what’s your favourite gene and why?” so for a bit of fun, I […]
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Mapping the Embryo for Developmental Biologists & Stem Cell Researchers; LifeMap Discovery® – a Roadmap of Mammalian Cell Ontology
Posted by arielrinon on March 30th, 2014
Understanding how cells differentiate during embryonic development is invaluable for the in vitro derivation of functional cells from stem cells. However, mapping the human embryo, including characterization of all the cell types that make up the developing and mature human body, and of all embryonic progenitor cell types that appear in intermediate developmental stages, is […]
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Negative findings: tackling the negativity
Posted by Paraminder Dhillon on March 18th, 2014
‘Science is often romanticised as a flawless system of knowledge building, where scientists work together to systematically find answers. In reality, this is not always the case. Dissemination of results are straightforward when the findings are positive, but what happens when you obtain results that support the null hypothesis, or do not fit with the […]
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Cellularization in Drosophila, University of Chicago Journal Club
Posted by UChicagoDRSB_JC on March 15th, 2014
Cellularization in Drosophila embryos is quite the remarkable process. After fertilization, nuclear division occurs rapidly but without cell membrane formation, leading to a syncytial embryo with many nuclei in a common cytoplasm. After 9 mitotic divisions, the nuclei begin migration to the periphery of the syncytium, such that nuclei line the plasma membrane of the […]
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In time of revision: of Wingless and morphogens
Posted by ama on December 27th, 2013
In time of revision: of Wingless and morphogens Alfonso Martinez Arias The recent publication of the important work of C. Alexandre, LA. Baena and JP. Vincent on the molecular requirements for Wingless signalling in Drosophila (http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12879.html) offers an opportunity to consider the relationship between ideas and facts in modern developmental biology. The work reports the […]
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Setting the record straight- an interview with Daniel St Johnston
Posted by the Node on December 3rd, 2013
Professor Daniel St Johnston is a prominent developmental biologist and the current director of the Gurdon Institute in Cambridge (UK). The St Johnston lab recently retracted two papers, in what Retraction Watch lauded as a poster case of ‘doing the right thing’. The Node interviewed Daniel and discussed the case, and how his experience highlighted […]
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Conflicts of Interest
Posted by Thomas Butts on October 28th, 2013
‘‘None of the scientists would comment on the record, for fear that it would affect their funding or that of their postdocs and graduate students’’ Nature, September 2012 ‘Is science wrong?’ The Economist, frontcover October 2013 A Disclaimer I have been very fortunate to come across senior scientists in my career who do not […]
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Evolution of the Human Neocortex: How Unique Are We?
Posted by Alexandra de Sousa on October 28th, 2013
“Evolution of the Human Neocortex: How Unique Are We?” was the question asked at the Wiston House in West Sussex from 22-25 September 2013. Although we were hardly the first to consider whether the human brain is something special, the ‘unique’ pileup of methodological approaches likely improved the dialogue on this topic. My own presentation sought […]
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Neocortex evolution and human uniqueness
Posted by SteveBriscoe on October 20th, 2013
“So God created mankind in his own image, in the image of God he created them; male and female he created them. God blessed them and said to them, ‘Be fruitful and increase in number; fill the earth and subdue it. Rule over the fish in the sea and the birds in the sky and over every living creature that moves on the […]
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- Hemogenic endothelium flexes some muscle [IN THIS ISSUE]
- Motor efferent axons lead the way [IN THIS ISSUE]
- On growth and gradients [IN THIS ISSUE]
- Developing concepts of wound healing [IN THIS ISSUE]
- miR-8 enables correct synaptogenesis [IN THIS ISSUE]
- Actomyosin networks and tissue morphogenesis [DEVELOPMENT AT A GLANCE]
- Bioengineering approaches to guide stem cell-based organogenesis [REVIEWS]
- Genomic imprinting in development, growth, behavior and stem cells [REVIEWS]
- CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons [RESEARCH REPORT]
- miR-8 controls synapse structure by repression of the actin regulator Enabled [RESEARCH ARTICLES]
- A conserved axon type hierarchy governing peripheral nerve assembly [RESEARCH ARTICLES]
- Growth control by a moving morphogen gradient during Drosophila eye development [RESEARCH ARTICLES]
- Arabidopsis UNHINGED encodes a VPS51 homolog and reveals a role for the GARP complex in leaf shape and vein patterning [RESEARCH ARTICLES]
- A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud [RESEARCH ARTICLES]
- Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D [RESEARCH ARTICLES]
- High-resolution analysis of gene activity during the Xenopus mid-blastula transition [RESEARCH ARTICLES]
- Semaphorin 5B is a repellent cue for sensory afferents projecting into the developing spinal cord [RESEARCH ARTICLES]
- Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation [RESEARCH ARTICLES]
- Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish [RESEARCH ARTICLES]
- sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis [Articles of interest in other COB journals]
- Cadherin switching during the formation and differentiation of the Drosophila mesoderm - implications for epithelial-to-mesenchymal transitions [Articles of interest in other COB journals]
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- Editorial Board
- Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers
- Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression
- Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish
- Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells
- Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear
- Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development
- Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta
- Editorial Board
- Do the BEAF insulator proteins regulate genes involved in cell polarity and neoplastic growth?
- Lhx1 is required in Müllerian duct epithelium for uterine development
- A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans
- Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis
- Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads
- CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways
- The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis
- Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones
- Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages
- Editorial Board
- Development and evolution of vertebrate cranial placodes
- Setting appropriate boundaries: Fate, patterning and competence at the neural plate border
- Establishing the pre-placodal region and breaking it into placodes with distinct identities
- Neural crest and placode interaction during the development of the cranial sensory system
- Signaling mechanisms controlling cranial placode neurogenesis and delamination
- Sensational placodes: Neurogenesis in the otic and olfactory systems
- The development of lateral line placodes: Taking a broader view
- The evolutionary history of vertebrate cranial placodes – I: Cell type evolution
- The evolutionary history of vertebrate cranial placodes II. Evolution of ectodermal patterning
- Corrigendum to: “Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung” [Dev. Biol. 353 (2011) 242–258]
- Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a /V2b cell fate determination
- Sulf1 influences the Shh morphogen gradient during the dorsal ventral patterning of the neural tube in Xenopus tropicalis
- Corrigendum to “Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung” [Dev. Biol. 350 (2011) 112–126]
- Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland
- Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis
- Editorial Board
- Impact
- Why you should publish your papers in Developmental Biology
- SDB 2014 Meeting Announcement
- Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death
- Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis
- Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis
- Epigenetic regulation of oogenesis and germ stem cell maintenance by the Drosophila histone methyltransferase Eggless/dSetDB1
- Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development
- The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera
- Retraction notice to “The human placenta is a hematopoietic organ during the embryonic and fetal periods of development” [Dev. Biol. 327 (2009) 24–33]
- Ecdysone differentially regulates metamorphic timing relative to 20-hydroxyecdysone by antagonizing juvenile Hormone in Drosophila melanogaster
- Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney
- Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice
- Cell signaling during development of Dictyostelium
- Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear
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- Dystrophic muscle environment induces changes in cell plasticity [Perspectives]
- DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos [Reviews]
- The diabetes gene Hhex maintains {delta}-cell differentiation and islet function [Research Communications]
- Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e [Research Communications]
- HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles [Research Papers]
- miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF{beta} and Wnt signaling [Research Papers]
- ATR checkpoint kinase and CRL1{beta}TRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks [Research Papers]
- Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression [Research Papers]
- Distinct regulatory mechanisms balance DegP proteolysis to maintain cellular fitness during heat stress [Research Papers]
- Root growth is modulated by differential hormonal sensitivity in neighboring cells [Research Papers]
- Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin [Errata]
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