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Revisiting an old puzzle with high-resolution, three-dimensional eyes

Posted by on September 19th, 2018

Sha Wang, Deborah Gumucio This article shares the story behind our recent Developmental Cell paper. It tells the history of this project and how three-dimensional (3D) observations at the individual cell level transformed our preconceived ideas and brought new insights into cell dynamics in the proliferative intestinal epithelium.   Epithelial tubes are present in many[…]

Publishing peer review reports

Posted by on September 5th, 2018

Last week, Development and our sister journal Journal of Cell Science signed an open letter coordinated by ASAPbio, signalling our intention to publish peer review reports alongside published papers. I’m really delighted to be making this commitment and wanted to take the opportunity to say a few words about our thinking behind this decision. So[…]

Why We Need More Women in Academia: An Undergraduate Interested in Developmental Biology

Posted by on August 28th, 2018

For some scientists, the decision to pursue a research career stems from a youthful curiosity for the natural world that gradually builds over many years. Whereas in others, there is single moment when they realize that their desired future involved research. My interest is a mix of both – I decided I was going to[…]

Preprints promote transparency and communication

Posted by on August 12th, 2018

Carmen Adriaens1, Gautam Dey2, Amanda Haage3, Wouter Masselink4 *, Sundar Ram Naganathan5, Lauren Neves6, Teresa Rayon7, Samantha Seah8, Srivats Venkataramanan9.   1. Center for Cancer Biology, VIB, KU Leuven, Leuven, Belgium & Center for Cancer Research, NCI/NIH, Bethesda, MD, USA 2. MRC Lab for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK 3. Department[…]

Stem cell makes its own niche: the story behind the paper

Posted by on July 7th, 2018

In our recent paper published in Nature, we unravel a new mechanism of an extracellular matrix protein secreted by muscle satellite (stem) cells, thereby playing the unusual role of acting as a signaling molecule to maintain the stem cell population. Here, I share the story behind this discovery and discuss the questions related to niche[…]

Towards understanding the quirks of human brain evolution

Posted by on June 28th, 2018

In early June, a group of 30 world-leading experts came together thanks to an invitation by the Company of Biologists to Wiston House (Sussex, UK) to discuss our current understanding about evolutionary and molecular mechanisms that contributed to developing the specific qualities of our human brains. Fortunately, the Company of Biologists offers fully funded participation[…]

Redefining the Aging Process

Posted by on May 4th, 2018

This post highlights the approach and findings of a new research article published in Disease Models and Mechanisms (DMM). This feature was written by J. Brucker Nourse Jr. as part of a graduate level seminar at The University of Alabama (taught by DMM Editorial Board member, Prof. Guy Caldwell) on current topics related to use[…]

YEN Conference 2018: Abstract submission and registration is open!

Posted by on April 11th, 2018

***Abstract Deadline is Saturday, 14th April!*** Young Embryologist Network Conference 2018 14th May 2018 The Francis Crick Institute, London, UK   This year we are pleased to announce Professor Wolf Reik as our keynote speaker. His research group, based at the Babraham Institute, investigates the roles of epigenetic gene regulation in mammalian development. We are also honoured to[…]

When the obvious fails, look at the unexpected: interneuron individual behavior affects the population migration.

Posted by on March 19th, 2018

The story behind our paper: Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Carla G. Silva, Elise Peyre, Mohit H. Adhikari, Sylvia Tielens, Sebastian Tanco, Petra Van Damme, Lorenza Magno, Nathalie Krusy, Gulistan Agirman, Maria M. Magiera, Nicoletta Kessaris, Brigitte Malgrange, Annie Andrieux, Carsten Janke, Laurent Nguyen   The research behind this article is a[…]

Why more is better in comparative developmental biology…

Posted by on January 26th, 2018

Our recent paper in “Nature” [1] deconstructs molecular arguments that have been used to homologize bilaterian nerve cords. Our work illustrates well the strength of the comparative approach and the broad sampling across the animal tree of life that we use in my research group at the Sars Centre for Marine Molecular Biology.   Evo-Devo[…]