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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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From bench to newspaper
Posted by Cat Vicente on February 20th, 2015
Alongside my main role as community manager of the Node I am also Development’s online editor, and one of my responsibilities is writing press releases. I recently wrote a press release on a Development paper that received some media attention, and I was surprised by the way the story was covered. The articles ranged from […]
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Reaching out – the many faces of science outreach
Posted by the Node on January 20th, 2015
This Spotlight was first published in Development. The days of the solitary scientist toiling away within the isolation of the academic ivory tower are something of the past. This is not only true when actually doing science, as projects become more collaborative and global, but also when considering the relationship between scientists and the public. Science outreach is something that most […]
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From naïve pluripotency to chimeras: a new ethical challenge?
Posted by the Node on December 18th, 2014
This article by Insoo Hyun was first published in Development. Also read the companion ethics article here. In recent years, there has been much interest in the prospect of generating and using human stem cells that exhibit a state of naïve pluripotency. Such a pluripotent state might be functionally confirmed by assessing the chimeric contribution of these cells to non-human blastocysts. Furthermore, the […]
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Ethical considerations in chimera research
Posted by the Node on December 18th, 2014
This article by Göran Hermerén was first published in Development. Also read the companion ethics article here. The development of human pluripotent stem cells has opened up the possibility to analyse the function of human cells and tissues in animal hosts, thus generating chimeras. Although such lines of research have great potential for both basic and translational science, they […]
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Looking inwards: opening a window onto human development
Posted by the Node on December 16th, 2014
This editorial was first published in Development. It was written by Olivier Pourquié, Benoit Bruneau, Gordon Keller and Austin Smith. The past 30 years or so have witnessed tremendous advances in the field of developmental biology. This has resulted in a growing (although still incomplete) understanding of the molecular basis of embryonic development, including characterization of signals and genes involved […]
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The Future of Research Symposium:
The Funding of Research
Posted by Gary McDowell on October 1st, 2014
This is the last of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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The Future of Research Symposium:
Metrics: The Folly of Hoping for X whilst Rewarding Y
Posted by Gary McDowell on September 29th, 2014
This is the third of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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The Future of Research Symposium:
The Structure of the Workforce
Posted by Gary McDowell on September 25th, 2014
This is the second of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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The Future of Research Symposium:
How Scientists are Trained
Posted by Gary McDowell on September 23rd, 2014
This is the first of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]
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What is your favourite conference venue?
Posted by Cat Vicente on September 10th, 2014
Last month I was lucky enough to attend the Xenopus meeting, which took place at the Asilomar conference grounds, close to Monterey, California. This meeting was fantastic, combining great science with a great venue. As there is already someone lined up to write about the scientific aspects of the meeting, I thought I would focus here instead on the […]
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- pancRNAs in early development [IN THIS ISSUE]
- Uncovering neurogenic potential of striatal astrocytes [IN THIS ISSUE]
- Timing degradation to tune development [IN THIS ISSUE]
- Getting to the heart of heart cell identity [IN THIS ISSUE]
- Asymmetric division and fate in the retina [IN THIS ISSUE]
- Neural development and regeneration: it's all in your spinal cord [MEETING REVIEW]
- A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation [REVIEW]
- Auxin-induced degradation dynamics set the pace for lateral root development [RESEARCH REPORT]
- Gene activation-associated long noncoding RNAs function in mouse preimplantation development [RESEARCH ARTICLES]
- A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella [RESEARCH ARTICLES]
- Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila [RESEARCH ARTICLES]
- Late Alk4/5/7 signaling is required for anterior skeletal patterning in sea urchin embryos [RESEARCH ARTICLES]
- Geometric control of ciliated band regulatory states in the sea urchin embryo [RESEARCH ARTICLES]
- The cytoplasmic domain of the gamete membrane fusion protein HAP2 targets the protein to the fusion site in Chlamydomonas and regulates the fusion reaction [RESEARCH ARTICLES]
- Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse [RESEARCH ARTICLES]
- Muscle composition is regulated by a Lox-TGF{beta} feedback loop [RESEARCH ARTICLES]
- Drosophila small heat shock protein CryAB ensures structural integrity of developing muscles, and proper muscle and heart performance [RESEARCH ARTICLES]
- Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs [RESEARCH ARTICLES]
- Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc [Articles of interest in other COB journals]
- miR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R [Articles of interest in other COB journals]
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- Editorial Board
- Letter from the editor – issue 399/1–1 March 2015
- Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling
- Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland
- A dual epimorphic and compensatory mode of heart regeneration in zebrafish
- p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas
- Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination
- Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction
- A diffusible signal derived from hematopoietic cells supports the survival and proliferation of regenerative cells during zebrafish fin fold regeneration
- Differential regenerative capacity of neonatal mouse hearts after cryoinjury
- Nephron proximal tubule patterning and corpuscles of Stannius formation are regulated by the sim1a transcription factor and retinoic acid in zebrafish
- Tie1 is required for lymphatic valve and collecting vessel development
- A requirement for Gch1 and tetrahydrobiopterin in embryonic development
- Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis
- The boule gene is essential for spermatogenesis of haploid insect male
- The requirement of histone modification by PRDM12 and Kdm4a for the development of pre-placodal ectoderm and neural crest in Xenopus
- The cochlear sensory epithelium derives from Wnt responsive cells in the dorsomedial otic cup
- Mesenchymal Wnt signaling Promotes formation of sternum and thoracic body wall
- Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to Human aniridia patients
- Cre recombinase-regulated Endothelin1 transgenic mouse lines: Novel tools for analysis of embryonic and adult disorders
- IFT46 plays an essential role in cilia development
- Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development
- BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints
- The myogenic repressor gene Holes in muscles is a direct transcriptional target of Twist and Tinman in the Drosophila embryonic mesoderm
- BMP-dependent gene repression cascade in Drosophila eggshell patterning
- Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila
- An oncologist׳s friend: How Xenopus contributes to cancer research
- Editorial Board
- From classical to current: Analyzing peripheral nervous system and spinal cord lineage and fate
- Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition
- Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis
- Ecdysone regulates morphogenesis and function of malpighian tubules in Drosophila melanogaster through EcR-B2 isoform
- Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development
- Effects of polysialic acid on sensory innervation of the cornea
- Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers
- Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during drosophila hematopoiesis
- Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development
- Foxp1/2/4 regulate endochondral ossification as a suppresser complex
- C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting
- E3 ubiquitin ligases promote progression of differentiation during C. elegans embryogenesis
- Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation
- DMRT1 is required for Müllerian duct formation in the chicken embryo
- Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development
- Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance
- Evolutionary variations in the expression of dorso-ventral patterning genes and the conservation of pioneer neurons in Tribolium castaneum
- Editorial Board
- Differential pleiotropy and HOX functional organization
- A method for using direct injection of plasmid DNA to study cis-regulatory element activity in F0 Xenopus embryos and tadpoles
- Developmental alterations of the C. elegans male anal depressor morphology and function require sex-specific cell autonomous and cell non-autonomous interactions
- PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans
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- Nuclear pore proteins and the control of genome functions [Reviews]
- The Ino80 complex prevents invasion of euchromatin into silent chromatin [Research Communications]
- Cas9 function and host genome sampling in Type II-A CRISPR-Cas adaptation [Research Communications]
- Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF [Research Papers]
- Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability [Research Papers]
- A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages [Research Papers]
- The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis [Research Papers]
- A high-sensitivity phospho-switch triggered by Cdk1 governs chromosome morphogenesis during cell division [Research Papers]
- Structural basis for corepressor assembly by the orphan nuclear receptor TLX [Research Papers]
- Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis [Research Papers]
- In vivo investigation of the transcription, processing, endonucleolytic activity, and functional relevance of the spatial distribution of a plant miRNA [Errata]
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- TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition
- CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere
- SCML2 Establishes the Male Germline Epigenome through Regulation of Histone H2A Ubiquitination
- Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry
- Mechanical Tension Drives Cell Membrane Fusion
- Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation
- Weaning Triggers a Maturation Step of Pancreatic β Cells
- A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis
- Puzzling Out Neurodevelopment
- The Evolution of Early Neurogenesis
- Neuronal Aggregates: Formation, Clearance, and Spreading
- Genetic Changes Shaping the Human Brain
- Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
- Programmed Cell Death in Neurodevelopment
- Microglia: Multitasking Specialists of the Brain
- Subcellular Patterning: Axonal Domains with Specialized Structure and Function
- Dynamics and Mechanisms of CNS Myelination
- It Takes a Village: Constructing the Neurogenic Niche
- Evolution of Patterning Systems and Circuit Elements for Locomotion
- Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!
