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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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Your non-model organism is going extinct
Posted by SAW on July 17th, 2014
“There is no such thing as a non-model organism” R. Behringer This bold statement was announced less than a week into our Embryology course and has left a lasting impression on lecturers and students alike. At first it seemed like a sympathetic statement to the extensive and diverse systems us students were arriving from… “yeah, […]
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Brazil: origins, evolution and future of developmental biology in the country of the 2014 World Cup
Posted by hmsouza on July 13th, 2014
By Henrique Marques-Souza and Rodrigo Nunes da Fonseca Widely known as the country of soccer, samba and beautiful beaches, one might wonder if it is possible to perform high quality research in Developmental Biology in Brazil with so many distractions. What are the pros and cons of doing research in this area in Brazil? […]
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Use it or Lose it: Insights on neuronal connections in the vertebrate retina
Posted by Reed College Dev Neuro on May 18th, 2014
This is the final post from our developmental neurobiology seminar this semester. Two students wrote about our discussion of the importance of neuronal activity during synaptogenesis and their professor combined and edited the pieces. As usual, we focused on development in the vertebrate retina. Hope you’ve enjoyed our contributions, we’ve enjoyed sharing our new-found understanding. […]
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Open study hopes to put STAP in the past
Posted by Eva Amsen on May 12th, 2014
This article is a re-post of an article published at the F1000Research blog on the 8th of May, 2014. Eva Amsen is the outreach director of F1000Research. Many of you will have been following the STAP stem cell saga: In January, researchers from Japan announced in Nature that they had produced induced pluripotent stem cells (iPS cells) […]
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Good guilt
Posted by Cat Vicente on May 7th, 2014
Seán Mac Fhearraigh, from PostPostDoc, recently asked me to write a post about my experiences outside academia. Because I don’t have a lot of experience yet (I have only been working as the Node community manager for less than a year) I decided instead to focus on what I did during my PhD that helped the transition. […]
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Exciting advances and scientific advice- the Node readers have their say!
Posted by the Node on April 25th, 2014
Last month we attended the joint meeting of the British Society for Developmental Biology and the British Society for Cell Biology in Warwick. At the time we had the opportunity to chat with Node readers, and gather their thoughts on two different questions: - What is the most exciting scientific advance of the last […]
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Flippase recognition target: orientation matters, so why care?
Posted by Mario Metzler on April 16th, 2014
FRT sites are used often (at least in Drosophila) for inducing deletions or “flipping out” of markers in transgenic constructs. When there are two FRTs sequences in tandem, after inducing flippase the DNA sequence that is between these two sites will be deleted. If two FRT sites are facing each other (or looking away), the […]
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What’s your favourite gene?
Posted by Lilian Hunt on April 11th, 2014
I recently took part in the ‘I’m a scientist, get me out of here!’ outreach event. As soon as the school children found out I was a developmental geneticist and worked out what I did, one question I was repeatedly asked was: “what’s your favourite gene and why?” so for a bit of fun, I […]
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Mapping the Embryo for Developmental Biologists & Stem Cell Researchers; LifeMap Discovery® – a Roadmap of Mammalian Cell Ontology
Posted by arielrinon on March 30th, 2014
Understanding how cells differentiate during embryonic development is invaluable for the in vitro derivation of functional cells from stem cells. However, mapping the human embryo, including characterization of all the cell types that make up the developing and mature human body, and of all embryonic progenitor cell types that appear in intermediate developmental stages, is […]
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Negative findings: tackling the negativity
Posted by Disease Models and Mechanisms on March 18th, 2014
‘Science is often romanticised as a flawless system of knowledge building, where scientists work together to systematically find answers. In reality, this is not always the case. Dissemination of results are straightforward when the findings are positive, but what happens when you obtain results that support the null hypothesis, or do not fit with the […]
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- talpid2: a mystery finally solved [IN THIS ISSUE]
- Starvation MESses up the egg [IN THIS ISSUE]
- A taste for something new [IN THIS ISSUE]
- Cell heterogeneity and multilineage priming in the kidney [IN THIS ISSUE]
- The POU-er of gene nomenclature [SPOTLIGHT]
- The dynamics of plant plasma membrane proteins: PINs and beyond [REVIEW]
- Retinoic acid controls body axis extension by directly repressing Fgf8 transcription [RESEARCH REPORTS]
- The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells [RESEARCH REPORTS]
- Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity [RESEARCH ARTICLES]
- Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium [RESEARCH ARTICLES]
- The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2 [RESEARCH ARTICLES]
- Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis [RESEARCH ARTICLES]
- A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex [RESEARCH ARTICLES]
- The origin and loss of periodic patterning in the turtle shell [RESEARCH ARTICLES]
- Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity [RESEARCH ARTICLES]
- Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis [RESEARCH ARTICLES]
- Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice [RESEARCH ARTICLES]
- Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system [RESEARCH ARTICLES]
- Islet is a key determinant of ascidian palp morphogenesis [RESEARCH ARTICLES]
- NF-kB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS [Articles of interest in other COB journals]
- The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila [Articles of interest in other COB journals]
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- Editorial Board
- The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo
- The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior–posterior neuroblast migration
- Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number
- Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton
- Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast
- Transcriptional regulation of Drosophila gonad formation
- Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly
- Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure
- Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1
- Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms
- Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation
- SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
- GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development
- Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation
- Specific pattern of cell cycle during limb fetal myogenesis
- Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development
- Nemo promotes Notch-mediated lateral inhibition downstream of proneural factors
- Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression
- Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos
- Hectd1 is required for development of the junctional zone of the placenta
- Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
- miR-203 regulates progenitor cell proliferation during adult zebrafish retina regeneration
- Dynamics of F-actin prefigure the structure of butterfly wing scales
- Germ cells of the centipede Strigamia maritima are specified early in embryonic development
- The expansion of body coloration involves coordinated evolution in cis and trans within the pigmentation regulatory network of Drosophila prostipennis
- Emergence of tissue sensitivity to Hox protein levels underlies the evolution of an adaptive morphological trait
- Long bone development requires a threshold of Hox function
- Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression
- A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues
- Editorial Board
- Development of the lateral line canal system through a bone remodeling process in zebrafish
- NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling
- Protein kinase CK2 both promotes robust proliferation and inhibits the proliferative fate in the C. elegans germ line
- TAF4b promotes mouse primordial follicle assembly and oocyte survival
- Regulation of broad by the Notch pathway affects timing of follicle cell development
- Cited2 is required in trophoblasts for correct placental capillary patterning
- Polyspermy block in jellyfish eggs: Collaborative controls by Ca2+ and MAPK
- The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless
- Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice
- Transcriptional co-regulation of evolutionarily conserved microRNA/cone opsin gene pairs: Implications for photoreceptor subtype specification
- Corrigendum to “prdm12b Specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements” [Dev. Biol. 390 (2014) 247–260]
- The proteins encoded by the drosophila planar polarity effector genes inturned, fuzzy and fritz interact physically and can re-pattern the accumulation of “upstream” planar cell polarity proteins.
- Short neuropeptide F (sNPF) is a stage-specific suppressor for juvenile Hormone biosynthesis by corpora allata, and a critical factor for the initiation of insect metamorphosis
- The contrasting roles of primary cilia and cytonemes in Hh signaling
- Corrigendum to “Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRII asynaptic accumulation and bouton number” [Dev. Biol. 392 (2014) 153–167]
- Formation of cholinergic synapse-like specializations at developing murine muscle spindles
- Ephrin-mediated restriction of ERK1/2 activity delimits the number of pigment cells in the Ciona CNS
- Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice
- Specification of the mouse cardiac conduction system in the absence of Endothelin signaling
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- Wnt some lose some: transcriptional governance of stem cells by Wnt/{beta}-catenin signaling [Reviews]
- Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling [Reviews]
- Two waves of de novo methylation during mouse germ cell development [Research Communications]
- TRF2, but not TBP, mediates the transcription of ribosomal protein genes [Research Communications]
- Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1 [Research Communications]
- The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages [Research Papers]
- Lineage of origin in rhabdomyosarcoma informs pharmacological response [Research Papers]
- Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions [Research Papers]
- A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication [Research Papers]
- MicL, a new {sigma}E-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein [Research Papers]
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- Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning
- Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Neural Stem Cells
- Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells
- The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors
- Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells
- SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication
- Mother Centrioles Do a Cartwheel to Produce Just One Daughter
- Walter Jakob Gehring (1939–2014)
- A Long Noncoding Way to Alternative Splicing in Plant Development
- Dll4 and PDGF-BB Convert Committed Skeletal Myoblasts to Pericytes without Erasing Their Myogenic Memory
- A Whiter Shade of Gray: HIF and Coordination of Angiogenesis with Postnatal Myelination
- Sizing Up Lung Stem Cells
- A Time and Place for Understanding Neural Stem Cell Specification
- Global Programmed Switch in Neural Daughter Cell Proliferation Mode Triggered by a Temporal Gene Cascade
- Long Noncoding RNA Modulates Alternative Splicing Regulators in
- EGFR Modulates DNA Synthesis and Repair through Tyr Phosphorylation of Histone H4
- Roles for Pbp1 and Caloric Restriction in Genome and Lifespan Maintenance via Suppression of RNA-DNA Hybrids
- High-Resolution Temporal Analysis Reveals a Functional Timeline for the Molecular Regulation of Cytokinesis
