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Deep into the developmental origins of neural tumours with Drosophila

Posted by on July 12th, 2016

Caroline Dillard and Cédric Maurange (Aix-Marseille University, CNRS, IBDM, Marseille)   Drosophila neural stem cells as a cancer model Transformation of a cell into a cancer cell is a complex process along which the cell acquires hallmarks as diverse as resistance to differentiation, infinite proliferative potential, metastasis, resistance to cell death, genome instability (Hanahan and[…]

June in preprints

Posted by on July 6th, 2016

In this new feature, we conduct a trawl for preprints to find the latest developmental biology and related research from the previous month. Scientists are increasingly using preprints as a way of releasing research to the community without having to wait for the peer review process, and we want to promote this content here. Several sites host[…]

Replicating spinal cord development with microfluidics

Posted by on July 5th, 2016

Unraveling Development Embryonic development is a complex and regulated spatiotemporal ensemble of signaling cues that control cell differentiation. Most of what we now know comes from experimenting directly on embryos. This provides biological realism, but involves a sea of uncontrolled/unobserved variables that sometimes obscures the basic underlying mechanisms. More recently, in vitro models, based on[…]

This month on the Node – June 2016

Posted by on July 1st, 2016

This month we welcomed Aidan to the Node, who took over from Cat as Community Manager, and introduced himself here. He’s been enjoying settling in to the Company of Biologists office, and getting to know the site and its users. We had 17 jobs and studentships posted on our jobs page,  on everything from chromatin to membrane dynamics. We[…]

Novel optogenetic probe for in vivo optogenetic control

Posted by on June 28th, 2016

Optogenetics has been widely used in the study of neural activity and behavior. By using genetic tools to target light-sensitive proteins to one or populations of neurons in specific region of brain, we can active those neurons by optical stimulation. The foundation of neuron interaction bases on the ion transmission through the neuron membrane. The[…]

In Development this week (Vol. 143, Issue 12)

Posted by on June 14th, 2016

Here are the highlights from the current issue of Development:   A distinct cartilage programme for bone regeneration Bone healing, for example fracture repair in humans, often involves a cartilage intermediate but how this tissue is induced and contributes to healing is unclear. Here, Gage Crump and co-workers show that regeneration of the zebrafish jawbone[…]

Sweetening with a pinch of salt: maximized Cas9 efficiency in zebrafish

Posted by on June 14th, 2016

  Alexa Burger, Mosimann lab, Institute of Molecular Life Sciences, University of Zürich, Switzerland. When I first heard about the “new” genome editing method in early 2013 called CRISPR-Cas9, I thought: “Never ever again will I work with targeted nucleases!” Now it’s mid-2016, we published our approaches to maximize Cas9 effectiveness in zebrafish with Development[…]

This month on the Node – May 2016

Posted by on June 1st, 2016

May was most notable for the departure of the Node’s brilliant Community Manager, Cat Vicente. Cat said her goodbyes here, but we’d like to take this opportunity to thank her again for her great work over the last 3 years. And Cat still found time to keep posting right up to the end – both[…]

This month on the Node- April 2016

Posted by on May 3rd, 2016

Here are some of the posts we featured on the Node in the last month!   Research – Chen-Hui wrote about skinbow,  a new system to study cell dynamics during epithelial regeneration in zebrafish. – Our latest evo devo post was by Andrew, who discusses his recent Development paper highlighting the similarities between Shh in the gill[…]

This month on the Node- March 2016

Posted by on April 1st, 2016

  Focus on organoids Following Development’s call for papers for their upcoming Special Issue on Organoids, we featured an interview with their guest editor Melissa Little, discussing her career and research on kidney development and organoids. Our question of the month focused specifically on brain organoids and the ethical issues involved. You can share your thoughts by leaving[…]