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Exciting news on neural stem cell niches: stunning research from Fiona Doetsch’s lab

Posted by on August 26th, 2016 Sense & Sensibility: niche signals regulate neural stem cells in an age-dependent manner paper feature by Thomas Schwarz-Romond Tissue specific stem cell niches provide lifelong support for adult stem cells. The cell-biological dissection of (adult neural) stem cell – niche interactions uncovered unexpected regulatory functions. These new results imply that stem cell niches actively[…]

The People Behind the Papers #2

Posted by on August 22nd, 2016

In this series, we interview the people behind some of the most exciting recent papers in developmental biology and related fields, to give context to the work and find out how the story came together.   Today’s paper is from the latest issue of Development and investigates the mechanisms of lizard tail regeneration, revealing distinct cell behaviours in[…]

The People Behind the Papers #1

Posted by on August 16th, 2016

In this new series, we interview the people behind some of the most exciting recent papers in developmental biology and related fields, to give context to the work and find out how the story came together. To inaugurate the series, we start with a paper that came out recently in Cell, and uncovered a mechanism for how nuclear pore[…]

A new role of an insect steroid hormone: The link between mating and germline stem cells

Posted by on August 11th, 2016

Tomotsune Ameku, Ryusuke Niwa’s lab, University of Tsukuba, Japan.   Steroid hormones have crucial roles in regulating a broad range of biological processes in most multicellular organisms. They are produced in specialized endocrine organs and act as ligands for the nuclear receptor family of transcription factors. In mammals, sex steroid hormones, such as estrogen and[…]

In Development this week (Vol. 143, Issue 15)

Posted by on August 2nd, 2016

Here are the highlights from the current issue of Development:   Defining Polycomb complexes with AEBP2 Polycomb repressive complex 2 (PRC2) directs methylation of histone H3 K27 (H3K27me), a repressive histone mark. Mutations in PRC2 complex components cause a spectrum of developmental defects, including posterior transformation of the skeleton due to misexpression of Hox cluster[…]

This month on the Node – July 2016

Posted by on August 1st, 2016

In case you missed it, here’s a round up of our July content, with lots of developmental biology research highlights (inc. microfluidics, zebrafinches and 3D retinas), as well as some art, some history, and some opinions. Happy reading! Research Christopher Demers wrote about microfluidic chambers and how they can be a useful tool for developmental biologists,  Carloine[…]

Deep into the developmental origins of neural tumours with Drosophila

Posted by on July 12th, 2016

Caroline Dillard and Cédric Maurange (Aix-Marseille University, CNRS, IBDM, Marseille)   Drosophila neural stem cells as a cancer model Transformation of a cell into a cancer cell is a complex process along which the cell acquires hallmarks as diverse as resistance to differentiation, infinite proliferative potential, metastasis, resistance to cell death, genome instability (Hanahan and[…]

June in preprints

Posted by on July 6th, 2016

In this new feature, we conduct a trawl for preprints to find the latest developmental biology and related research from the previous month. Scientists are increasingly using preprints as a way of releasing research to the community without having to wait for the peer review process, and we want to promote this content here. Several sites host[…]

Replicating spinal cord development with microfluidics

Posted by on July 5th, 2016

Unraveling Development Embryonic development is a complex and regulated spatiotemporal ensemble of signaling cues that control cell differentiation. Most of what we now know comes from experimenting directly on embryos. This provides biological realism, but involves a sea of uncontrolled/unobserved variables that sometimes obscures the basic underlying mechanisms. More recently, in vitro models, based on[…]

This month on the Node – June 2016

Posted by on July 1st, 2016

This month we welcomed Aidan to the Node, who took over from Cat as Community Manager, and introduced himself here. He’s been enjoying settling in to the Company of Biologists office, and getting to know the site and its users. We had 17 jobs and studentships posted on our jobs page,  on everything from chromatin to membrane dynamics. We[…]