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Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley

Posted by on September 23rd, 2016

  “…had you told me when I was 25 years old that I would be the director of a cancer center I would have been incredulous, given that I was totally into chemistry”   This is an extract from an interview that originally appeared in Disease Models and Mechanisms (available here Open Access) Paraminder Dhillon,[…]

Where does blood come from in the first place and how is it made?

Posted by on September 14th, 2016

Commentary on Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells in Developmental Cell, Volume 38, Issue 4, p358–370, 22 August 2016   Each of us has around 6 pints of blood. The blood contains a number of different types of cells, including oxygen-transporting red blood cells, disease-protecting white[…]

From our sister journals – August 2016

Posted by on September 6th, 2016

Here we highlight some developmental biology related content from other journals published by The Company of Biologists. Meritxell Huch, Wellcome Trust Sir Henry Dale Fellow at the Gurdon Institute in Cambridge, was interviewed as a Cell Scientist to Watch (she’s certainly one for developmental biologists to watch too!).   The Tanentzapf lab assayed the effects of outside-in integrin[…]

August in preprints

Posted by on September 5th, 2016

Our latest monthly trawl for developmental biology (and other cool) preprints. See June’s post for background, and let us know if we missed anything It was another bumper month for preprints, as bioRxiv’s Richard Sever celebrated:     This month we found three pieces on the development of the spinal cord, three investigations into gene expression networks in the[…]

This month on the Node

Posted by on September 5th, 2016

August was meant to be a quiet month, with researchers (in Europe, at least)  leaving the lab for a well earned break and winding down before the start of the academic year…but here on the Node we’ve had another bumper month full of diverse content. Happy reading!   Meetings   We had a wonderful report from Joaquín Navajas[…]

Exciting news on neural stem cell niches: stunning research from Fiona Doetsch’s lab

Posted by on August 26th, 2016

http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30163-1 Sense & Sensibility: niche signals regulate neural stem cells in an age-dependent manner paper feature by Thomas Schwarz-Romond Tissue specific stem cell niches provide lifelong support for adult stem cells. The cell-biological dissection of (adult neural) stem cell – niche interactions uncovered unexpected regulatory functions. These new results imply that stem cell niches actively[…]

The People Behind the Papers #2

Posted by on August 22nd, 2016

In this series, we interview the people behind some of the most exciting recent papers in developmental biology and related fields, to give context to the work and find out how the story came together.   Today’s paper is from the latest issue of Development and investigates the mechanisms of lizard tail regeneration, revealing distinct cell behaviours in[…]

The People Behind the Papers #1

Posted by on August 16th, 2016

In this new series, we interview the people behind some of the most exciting recent papers in developmental biology and related fields, to give context to the work and find out how the story came together. To inaugurate the series, we start with a paper that came out recently in Cell, and uncovered a mechanism for how nuclear pore[…]

A new role of an insect steroid hormone: The link between mating and germline stem cells

Posted by on August 11th, 2016

Tomotsune Ameku, Ryusuke Niwa’s lab, University of Tsukuba, Japan.   Steroid hormones have crucial roles in regulating a broad range of biological processes in most multicellular organisms. They are produced in specialized endocrine organs and act as ligands for the nuclear receptor family of transcription factors. In mammals, sex steroid hormones, such as estrogen and[…]

In Development this week (Vol. 143, Issue 15)

Posted by on August 2nd, 2016

Here are the highlights from the current issue of Development:   Defining Polycomb complexes with AEBP2 Polycomb repressive complex 2 (PRC2) directs methylation of histone H3 K27 (H3K27me), a repressive histone mark. Mutations in PRC2 complex components cause a spectrum of developmental defects, including posterior transformation of the skeleton due to misexpression of Hox cluster[…]