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From basic questions to exciting findings

Posted by on May 21st, 2018

In this post we report the backstories behind our recently published paper. It was an enjoyable research adventure driven by discussions, readings, exciting experiments and unexpected discoveries. As a result, we described a novel molecular mechanism underpinning stem cell and progenitor maintenance during development. Here is the sequence of the main events that inspired us[…]

April in preprints

Posted by on May 3rd, 2018

Another bumper month for developmental biology and related preprints, this time featuring spiders, lampreys, amphiouxus and plenty of zebrafish, worm and fly research. Also a big month for fans of Sox genes, which turned up in the title of five preprints! My visual highlight is the preprint from David Parichy’s group on zebrafish scale development[…]

First impressions of the BSDB Spring Meeting

Posted by on April 24th, 2018

This year, is the BSDB’s 70th anniversary, and this was clearly reflected at our Spring Meeting, 15-18 April 2018 in Warwick! Apart from an outstanding speaker list, and the award of most BSDB medals & prizes of 2018, we saw a history session which looked back at the past, to then project into the future of[…]

A BSDB history rap!!!!

Posted by on April 13th, 2018

  This year, is the BSDB’s 70th anniversary! Expect many extras on our Spring Meeting (15-18 April 2018 in Warwick)! For example, the history rap, a contemporary oral rendering of BSDB history, featuring Jerry aka Gerald H Thomsen PhD and produced and mixed by Philip Larsen – BSDB member and DJ! (+1 rating, 1 votes) Loading…

March in preprints

Posted by on April 4th, 2018

One of the most talked about preprints this month was a corrigendum to that Nature Methods paper reporting widespread off-target mutations following CRISPR-Cas9 editing in  mice. The paper was challenged quickly on bioRxiv, and four days after the corrigendum went up, it was retracted, as reported by Retraction Watch! Blink and you’ll miss it. Otherwise this month[…]

February in preprints

Posted by on March 1st, 2018

Our latest monthly trawl for developmental biology (and other cool) preprints. Let us know if we missed anything.   On February 20th, The Company of Biologists launched preLights, a community-led preprint highlighting service. A panel of early career researchers (the ‘preLighters’) select and comment on recent preprints that caught their eye, and encourage preprint authors[…]

What an amazing workshop by Madeline Lancaster, Denis Jabaudon and The Company of Biologists!

Posted by on February 28th, 2018

How do cells give rise to the functional architecture of the brain? This is no longer a neuroscience-only question. Indeed, it is a cellular, genetic, developmental, mechanical, and material problem that requires experts from all of these disciplines working together to understand how the brain works! Yet, from this architectural design perspective, it is very[…]

January in preprints

Posted by on February 2nd, 2018

Our latest monthly trawl for developmental biology (and other cool) preprints. Let us know if we missed anything. Here at the Company of Biologists we are very excited about our soon to launch biology preprints highlighting service, preLights. Before the site goes live, you can sign up for email updates here and follow preLights on[…]

Prevent p-value parroting

Posted by on February 1st, 2018

Recently, Nature published my correspondence “Dispense with redundant P values”. It highlights my concern that p-values are often calculated because “everybody does it”. This reminded me of the mechanical repetition that parrots are well-known for (footnote 1). Parroting of p-value reporting should stop and I suggest to only present a p-value in a figure if[…]

Why more is better in comparative developmental biology…

Posted by on January 26th, 2018

Our recent paper in “Nature” [1] deconstructs molecular arguments that have been used to homologize bilaterian nerve cords. Our work illustrates well the strength of the comparative approach and the broad sampling across the animal tree of life that we use in my research group at the Sars Centre for Marine Molecular Biology.   Evo-Devo[…]