This month on the Node – January 2012

Posted by on January 31st, 2012

This round-up also includes a few posts from the end of December that didn’t make it into December’s post due to holiday scheduling.

Developmental Biology Bingo Game
We made a bingo game! You all left many suggestions for words to include in a developmental biology bingo game, and BenchFly turned that into a playable game. Visit their site to download bingo cards for everyone in your lab.

SDB CoRe
The SDB has set up a collaborative resource for teaching materials to use in developmental biology courses, and they are looking for submissions. Do you have great visuals that can be used in undergraduate teaching? Let Marsha Lucas know. She left more information in her post earlier this week.


Research

Just before Christmas, Hillel Kugler, of Microsoft Research, wrote about a project he worked on with Jane Albert Hubbard’s lab at the Skirball Institute.

“In our study, published in Development, we have built a computational model of germline development in C. elegans. In this model, germ cells move, divide, respond to signals, progress through mitosis and meiosis, and differentiate according to a developmental program specified for a “cell”. This developmental program incorporates cellular decision-making that influences germ cell behavior, as defined by a subset of cell components and their dynamic interactions.”

Other research recently covered on the Node included a paper that showed that a small change in bioelectric signals is enough to induce eye development in Xenopus, and an image highlighting the importance of Notch signaling in stem cell self-renewal and intestinal homeostasis.

Write for the Node
If you’re interested in writing for the Node, all you have to do is create an account and wait for approval. But sometimes inspiration is the limiting factor. If you’d love to write, and just want some suggestions and ideas, you can fill out this form, and we’ll occasionally send you some ideas. The first email has gone out this week, but if you sign up now, you’ll get that sent as soon as possible.

Books
Finally, we saw a few more book reviews this month. The last of the Development book reviews went up, in which Wendy Bickmore reviews “The Nucleus” (Edited by Tom Misteli and David L. Spector). We started 2012 with the first Node-exclusive book review: Sasha Terashiva reviewed “The Cell: A Very Short Introduction” (by Terence Allen and Graham Cowling).
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This month on the Node – December 2011

Posted by on December 30th, 2011

Many of you may have a few days off from work at the moment. If you want to catch up on what you missed on the Node this month, read on:

BenchFly bingo game

Benchfly, a site with free video protocols and other resources for researchers, has created “Group Meeting Bingo”. The site generates bingo cards with the particular phrases common to various fields of research. They have cards for biochemistry, cell biology, and various other fields, but no developmental biology…yet!

So, let’s make a developmental biology bingo game!

Add suggestions for words to include to the post. We already have quite a few, but I’m sure you’ll find something that hasn’t been mentioned yet. You still have this weekend to add words.

Rejuvenating old cells

With the new year approaching, you may have been pondering the passage of time lately. Another year gone, another year older. But there’s hope still! Sasha wrote about a recent paper that shows that your cells are never too old for pluripotency!

”(…) Researchers began to wonder whether cellular aging was a barrier to iPS cell conversion. In a recent paper published the November issue of Genes in Development, entitled “Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state,” Lapasset and colleagues from the Institute of Functional Genomics in France report that they have overcome this barrier and generated iPS cells from human donors as old as 101 years.”

Book reviews

Continuing from last month, we’ve republished more book reviews from Development. Click on a cover to read the review.

  


     


Also on the Node:
- Dates and deadlines, including an extended early registration deadline for the LASDB meeting
-“Pigs that Fly” - Jonathan’s third rotation lab for the Wellcome Trust PhD programme.
- For more, see the full December archive.

 
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Stem cells, cellules souches, Stammzellen: taking research to Europe’s public

Posted by on December 22nd, 2011

It’s been a busy year for EuroStemCell: Europe’s stem cell hub - see www.eurostemcell.org for more information on who we are. We’d like to wish The Node community a happy festive season and a great start to 2012. But before we say goodbye to 2011, we thought you might be interested to know about some of the things we’ve been doing recently…

EuroStemCell goes multilingual


eurostemcell.org is multilingual! Or tri-lingual, at least.

The EuroStemCell website is now available in 2 additional languages, German and French, with Italian and Spanish coming soon. Just click on the flag icons to the right of any page on the website to give the newly translated interface a whirl.

Read more about our translation project, or go straight to the French or German homepage.


Research updates from EU-funded stem cell projects

Our research updates keep you informed about progress in public-funded European stem cell research. Here’s a recent example from our partner, NeuroStemcell.


Using stem cells to develop new therapies for Parkinson’s and Huntington’s diseases


NeuroStemcell brings stem cell biology and clinical science together to develop and test new approaches to stem-cell-based therapy. We study Parkinson’s (PD) and Huntington’s (HD) diseases, which are degenerative diseases of the brain.

Read more about NeuroStemcell

 

Italy meets the UK to discuss the future of stem cells in the clinic




Over 100 Italian and UK scientists and politicians came together on 12 December for a Summit on Regenerative Medicine organized by the Italian Embassy in London and the School of Science Technology and Health, University Campus Suffolk. Their aim: to bring the collective expertise of academics, industry and the political world to bear on the question of how to take basic stem cell research towards the clinic.

We went along to the meeting - read our report on the discussions



Inside the lab

We’ve got two new guest bloggers on our site: Anestis Tsakiridis is sharing his insider’s view of stem cell research in his blogs, Behind the Bench: A series about researchers and their rituals; and we’re delighted to welcome Alzheimer’s researcher Selina Wray, who posted her first blog, A fish out of water, on our site just last week.

Meet the stem cell scientists

We’ve also been busy talking to experts across the stem cell field. Read our interviews with Cedric Blanpain, Yann Barrandon, Christine Mummery, Doug Sipp, Karen English and Nick Barker on the site now and keep your eye out for our chats with Jane Visvader, Connie Eaves and others in the New Year.

Stem cell factsheets


We’ve got an ever-growing set of fact sheets giving quick access to the key facts about different areas of stem cell and regenerative medicine research. The content is written by researchers and  reviewed by senior scientists.  The fact sheets are designed for non-specialists but why not check them out next time for a quick overview next time someone asks you about something a little outside your own field? Take a look at the whole collection (13 published so far, some in French & German too), but here’s one of our latest…

Type 1 Diabetes: How could stem cells help?

Diabetes is a common life-long condition and the number of children being diagnosed with type 1 diabetes is increasing. The symptoms can be controlled but there is no cure. For many, diabetes means living with daily insulin injections and the possibility of long-term damage to their health. How might stem cells help?Read our factsheet about stem cells and diabetes


 

Keep up with Europe’s stem cell news

Sign up to our newsletter to stay in touch with all the latest news from the EuroStemCell project. From February 2012 we’ll be sending out a  monthly newsletter. For more regular updates, you can follow us on Twitter, check out our Facebook page or subscribe to our RSS feeds.  And if you haven’t visited the site for a while, do take a look and get in touch with your feedback and ideas.
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This month on the Node – November 2011

Posted by on November 30th, 2011

What was new on the Node this month? Here are a few of the highlights from November:

New Research:
Several exciting new research papers were discussed on the Node this month. In one post, Stas Shvartsman introduces a recent Development paper from his own lab that describes a method to quantify the spatial range of morphogen gradients.

“Our paper provides a practical definition of the range of a morphogen gradient, a statistical procedure for estimating this range, a demonstration of this procedure in practice, and several independent experimental tests of derived estimates. From the biological standpoint, the range of a gradient can be viewed as the distance over which it acts as a spatial regulator of cell responses.”

This method from the Shvartsman lab can be applied to other systems. Find out more in the post.

Elsewhere, Erin Campbell highlights an image from a paper by Andrei Mardaryev et al., showing that Lhx2 in hair follicle stem cells regulates epidermal regeneration after injury.

Paul O’Neill writes about a new Nature paper from Yoshiki Sasai’s lab at RIKEN CDB, in which the authors describe how they generated functional pituitary gland tissue from mouse ES cells in vitro.

Graduate students
The Node also addressed graduate student issues this month, both the fictional and the factual.

For the past 14 years, the web comic Piled Higher and Deeper has looked specifically at the ups and downs of graduate student life. The comic is now a movie, and the Node had a chance to catch up with creator Jorge Cham at a screening of the film in London.

If you’d rather watch a more serious film involving graduate students, take a look at Stand With Science, in which MIT students urge US Congress not to cut science funding.



Also on the Node:
- Over the next few weeks, we’ll re-post this year’s batch of book reviews for Development, starting with this Star Trek-themed review of “Imaging in Developmental Biology”. We’ll also have some reviews unique to the Node, so keep an eye on the site!

- Finally, Elena Kardash explains how to find a place to practice piano when you’re in Barcelona for a brief research stint…
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This month on the Node – October 2011

Posted by on October 31st, 2011

What was new on the Node this month? Here are a few of the highlights from October:

MacArthur genius grant for Yukiko Yamashita

Sasha Terashima interviewed Yukiko Yamashita, one of this year’s MacArthur Fellows. The MacArthur foundation hands out “genius grants” of half a million dollars to a select group of people in all areas of arts, science, and humanities. There is no application process, and recipients are free to choose what they do with the money. Half a million out of the blue, with no strings attached - how would you react if you got that phone call?

“When Yukiko received the phone call informing her about being selected and asking her asking her not to discuss it with anyone except her spouse until the official announcement, she had a hard time believing that it was not a scam. “I called my husband right after I hung up my phone call with the foundation and [he] seriously warned me that ‘if you get a second phone call asking your bank account and pin number, so that they can transfer the award money, don’t give it to them.’” “

Academic teaching
If you teach plant science courses, make sure to have a look at Teaching Tools in Plant Biology. In the comments, Mary Williams give some additional advice.

Meanwhile, Lucia Prieto Godino travelled to Uganda to coordinate a course on insect neuroscience and Drosophila neurogenetics. The course members are graduate students and Junior Faculty from Uganda, Tanzania, Kenya, Malawi, Nigeria, and Cameroon, and in the course they will learn how to effectively use insects to teach or do research in neuroscience. In a later post, Lucia updated us on the course progress after the first few weeks.


One student in the course explains the experiment on olfactory choice in Drosophila that his group performed the day before.

Meetings, Jobs, and more Interviews:
- The entire Company of Biologists Workshop on Growth, Division and Differentiation is covered in a series of posts from the meeting.
- Several PhD and postdoc positions have been posted on the jobs page.
- Interviews with Development Editors Gordon Keller and Ottoline Leyser were reposted on the Node. The interview with Ottoline Leyser sparked a lively discussion on Twitter - more about that later today!

See the full October archive here.
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This month on the Node – September 2011

Posted by on September 30th, 2011

What was new on the Node this month? Here are a few of the highlights from September:

EMBO meeting
Natascha Bushati attended the EMBO meeting, and wrote several posts as one of their certified bloggers, including two interviews that are definitely worth a read: one with Janet Rossant, and a joint interview with Eric Wieschaus and Marcos González-Gaitán. Below are some quotes, but there’s much more in the full interviews.

“At the end of the day, when people believe that a human embryo from the time of conception is worthy of all protection, you cannot argue against that. All I can argue is that we are in a situation where human embryos through IVF programmes are discarded, and isn’t it more ethically acceptable to use those discarded embryos to help save human lives in the future?”Janet Rossant

“We think of proteins and genes, but there are all also lipids and sugars, and we are ignoring them completely! Maybe the future could be to measure them, find out where they are and how they influence things. Chemistry could be the future.” - Marcos González-Gaitán

“The reality is that model systems, at least in the fields we work in, exist not because it has anything to do with generality, but because experiments were easy to do in them.”Eric Wieschaus

 

Section of chicken and turtle ribsJapan
This past month saw several posts about (research from) Japan: Bruno Velutini summarized turtle shell development research from the Kuratani lab, Paul O’Neill featured a new study on transparent mice, also from the RIKEN institute, and Mubarak Hussain Syed wrote about the developmental neurobiology course he took this summer in Okinawa.

OIST course participants

 
Careers
* Thomas Butts expressed his concern about the future of UK science careers in his contribution to the latest Science is Vital campaign.
* An article summarizing the Node’s alternative careers posts was published in Development (and on the Node) at the start of the month.
* Finally, as always, check out the job listings on the Node for the latest openings in labs around the world.


Everything else:
Still want more? Browse the full September archive of posts to see the rest of the month!
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