Postdoctoral position in the research group of Dr. Nikolay Ninov at the Center for Regenerative Therapies Dresden and the Paul Langerhans Institute Dresden (PLID) (of Helmholtz Zentrum München and the German Center for Diabetes Research (DZD e.V.).
Our goal is to understand beta-cell regeneration and function in vivo in order to develop innovative cures for diabetes. We use the zebrafish as a model organism. The zebrafish is ideal to observe the behavior of beta-cells in their endogenous environment using live imaging. To do so, we have developed new tools to visualize beta-cell function and proliferation while performing genetic and lineage-tracing analysis (see Janjuha et al., 2018; Singh et al., 2018, Alfar et al., 2017; Spanjaard et al. 2018).
Currently, we are focusing on the following projects:
1) To identify systemic and local signals that regulate beta-cell function and maturation in vivo.
2) To define the role of cellular stress and inflammation in beta-cell plasticity
3) To uncover novel signals that can reignite regeneration of quiescent, mature beta-cells
The position is available 01.01.2019 or earlier. We offer a contract until 31.12.2020. The period of employment is governed by the Fixed Term Research Contract Act (WissZeitVG). Applications from women and people with disabilities are particularly welcome. We encourage applicants who are keen in acquiring independent funding and have at least one first-author publication.
Please send your application as one single pdf document:
1. Cover letter, indicating current and future research interests and motivation to join our group.
2. CV including description of research experience and publications
Please submit your application by June 14, 2018 using the following link
For more information please see:
Janjuha S., Singh SP., Tsakmaki A., Gharavy NM., Murawala P., Konantz J., Birke S., Hodson D., Rutter G., Bewick G., and Ninov N. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLIFE (2018), doi: 10.7554/eLife.32965
Spanjaard B.; Hu B.; Mitic N.; Olivares-Chauvet P.; Janjuha S.; Ninov N.; Junker J.P.; Simultaneous lineage tracing and cell type identification using CRISPR/Cas9 induced genetic scars Nature Biotechnology (2018), doi: 10.1038/nbt.4124
Singh SP, Janjuha S, Hartmann T, Kayısoglu O, Konantz J, Birke S, Murawala P, Alfar EA, Murata K, Eugster A, Tsuji N, Morrissey E, Brand M, and Ninov N. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature Communications (2017). DOI : 10.1038/s41467-017-00461-3.
Alfar EA, Kirova D, Konantz J, Birke S, Mansfeld J, and Ninov N. Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity. Scientific Reports (2017) 7(1):3994. doi: 10.1038/s41598-017-03873-9.
Janjuha S*., Singh SP*, and Ninov N. Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets. JoVE (in press)