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Displaying posts with the tag: cell-cycle [Clear Filter]

Making of the nerve cord: The story of telling neural progenitors when and where not to divide

Posted by on May 5th, 2017

Comment on “Anterior-Posterior Gradient in Neural Stem and Daughter Cell Proliferation Governed by Spatial and Temporal Hox Control”, Current Biology 27, 1161-1172 (2017). Ignacio Monedero, Behzad Yaghmaeian, Stefan Thor. Department of Clinical and Experimental Medicine, Linkoping University, Sweden.   How cells are generated in proper numbers in order to form specific structures in an organism[…]

An interview with Philip Zegerman

Posted by on September 15th, 2015

This interview first featured in the Journal of Cell Science and is part of their interview series Cell Scientists to Watch   Philip Zegerman earned his undergraduate degree from the University of Cambridge, where he later also pursued a PhD in the lab of Tony Kouzarides at the Gurdon Institute. For his postdoctoral work, he switched[…]

Camelid antibodies go fishing

Posted by on May 18th, 2015

Figure 1. “Cytoplasm”, illustration by David S. Goodsell, the Scripps Research Institute.   When contemplating the illustrations by David S. Goodsell (Figure 1), the first thing that stands out is how cells are packed full with those wonderful little machines we call proteins. They move, interact and change shape to produce cellular functions, so our ability[…]

Neuroblastoma may arise from problems with embryonic nerve development

Posted by on May 1st, 2015

Neuroblastoma is a tumour derived from the peripheral nervous system and is the most common cancer diagnosed within the first year of life. Although is a fairly rare disease, it does account for 15% of all pediatric cancer deaths. However, neuroblastoma is quite unique in that some, particularly very young, patients spontaneously regress requiring only[…]

Application of Fucci technology to analysis of endoreplicating cells

Posted by on November 18th, 2013

Endoreplication (endoreduplication or endomitosis) is the process by which a cell undergoes successive rounds of DNA replication without an intervening mitosis and its accompanying cytokinesis. Developmentally programmed endoreplication causes differentiating cells, such as TGCs and megakaryocytes (MKCs), to become highly polyploid. Our recent study published in Development (Sakaue-Sawano et al., 2013) comparatively characterized endoreduplication (TGCs)[…]

Wave at the frogs – they’re waving at you

Posted by on July 26th, 2013

  Perhaps, like me, you’ve been microinjecting Xenopus embryos for so long that you start seeing strange things – maybe that they’re waving at you.  But perhaps that’s not so crazy as it sounds.  In a letter to Nature this week (you can also view this talk), Jeremy Chang and James Ferrell Jr. from Stanford discuss the evidence[…]

Stem cell decisions and the cell cycle

Posted by on February 15th, 2013

A lot of things cycle in life, even down to the cellular level.  In the developing central nervous system, regulators of the cell cycle play important roles in maintaining the balance between stem cell self-renewal and differentiation.  A recent paper in the journal Development describes a cell cycle regulator in stem and progenitor cells in[…]

Postdoctoral position – MRC Department of Biomedical/Developmental Genetics, University of Sheffield, UK

Posted by on October 26th, 2011

Overview The Research Associate will work in the MRC Centre for Developmental and Biomedical Genetics within the Department of Biomedical Science.  The department has an active community of researchers specialising in different aspects of developmental biology.  You will take part in a project aiming to understand how cell proliferation is temporally integrated with digit patterning[…]

Yukiko Yamashita, a developmental biologist at U-M, named one of this year’s MacArthur fellows

Posted by on October 13th, 2011

What would you do if you were given $500,000 to fund your research for five years, with no strings attached –– no proposals to write, no progress reports to submit? If you were one of the recently announced recipients of the prestigious MacArthur fellowship you would be giving this question some serious thought. Every year[…]

Company of Biologists Workshop – Growth, Division and Differentiation – Day 3 – afternoon

Posted by on October 7th, 2011

As a follow up to Ben Martynoga’s post from yesterday, here is some more information on the topics covered in this excellent workshop that took place a couple of weeks ago. After extensive revolutions around the cell cycle in many of the previous sessions, Ryoichiro Kageyama introduced quite a different rhythm to the meeting in[…]