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Displaying posts with the tag: drosophila [Clear Filter]

Collaboration: All the things we cannot see (alone).

Posted by on June 3rd, 2019

By Miriam Rosenberg and Suparna Ray Most of what we know about axial patterning in insects comes from decades of careful, beautiful work done in flies. Thanks to the genetic screens of Christiane Nüsslein-Volhard and Eric Wieschaus in the late 1970’s, we learned that distinct classes of genes, many of them transcription factors, act in[…]

Publishing Fly Research

Posted by on May 9th, 2019

Back in January, The Cambridge Fly Club held a symposium to mark 25 years since the publication of the famous Gal4/UAS paper (Brand & Perrimon, 1993 – published in Development); the organisers have posted a meeting report here. As part of this symposium, the organisers asked me to give a talk on ‘Publishing Fly Research’.[…]

Functional interrogation of the C-terminal domain of RNA polymerase II in fruit flies

Posted by on April 24th, 2019

Feiyue Lu and David Gilmour tell the story behind their recent paper in Molecular Cell RNA polymerase II (Pol II) is the enzyme responsible for transcribing most genes in eukaryotes. The C-terminal domain (CTD) is a highly repetitive, unstructured domain on the largest Pol II subunit, Rpb1. It consists of numerous repeats of seven amino acids[…]

Imaging by computer and drawing by hand

Posted by on March 19th, 2019

An artist and a cultural historian of science visiting the European Molecular Biology Lab (EMBL) Gemma Anderson (University of Exeter) and Janina Wellmann (MECS, Leuphana University Lüneburg) Since Steve Woolgar’s and Bruno Latour’s study Laboratory Life was published in 1979 it has become part of the repertoire of STS scholars and anthropologists to visit the[…]

Genetics Unzipped podcast – Supermodels of science

Posted by on February 28th, 2019

 In this episode from our series exploring 100 ideas in genetics, we’re entering the glamorous world of modelling, meeting the supermodels… of science. We’re taking a look at some of the field’s top models – the eclectic collection of organisms that have been put to work in the lab to reveal the secrets of biology.[…]

Postdoctoral opportunity in image analysis and biophysical modeling of developing systems

Posted by on January 8th, 2019

Postdoctoral position in the Saunders laboratory, Mechanobiology Institute, Singapore A postdoctoral research position in quantitative biology is available from March 2019 in Asst. Prof. Timothy Saunders’ group at the Mechanobiology Institute, Singapore. The Saunders lab has been active since 2013 and studies the fundamental processes shaping organs and tissues during development. The Saunders lab extensively[…]

Postdoctoral position in Chromatin and Epigenetics in Drosophila Development

Posted by on December 19th, 2018

Stockholm University, Sweden, invites applications for one postdoctoral position in the laboratory of Professor Mattias Mannervik at the Department of Molecular Biosciences, The Wenner-Gren Institute (http://www.su.se/mbw). The position is scheduled to start as soon as possible. Transcriptional coregulators are proteins that facilitate communication between transcription factors and the basal transcription apparatus, in part by affecting[…]

Wire together, remodel together

Posted by on November 15th, 2018

Newborn babies are a symbol of immense potential, as they can grow up to be become virtually anybody, from an astronaut to the president. It is no secret that throughout life, there are critical junctions in which specific events or decisions can direct us on one path or another. Such events occur in our brains;[…]

Sex combs in motion

Posted by on November 14th, 2018

Using computer simulations and mathematical modeling to study the evolution of morphogenesis   Juan N. Malagon and Ernest Ho tell the story behind their recent paper in PLOS Computational Biology. In the Larsen lab, we are interested in testing a 50-year old question: How do sex combs rotate in fruit flies? Despite extensive studies of the[…]

1 PhD Position : Characterization of Hedgehog morphogens in vitro and in vivo

Posted by on October 18th, 2018

1 PhD Position : Characterization of Hedgehog morphogens in vitro and in vivo Hedgehog (Hh) morphogens play important roles in development and cancer, but their mode of extracellular transport to target cells is only poorly understood. Thus, we aim at the characterization of various unusual posttranslational regulatory mechanisms in Hh biology, such as Hh multimerization[…]