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Manchester PhD position on neuronal development, ageing & degeneration

Posted by on October 17th, 2017

The University of Manchester, 2018/19 BBSRC DTP PhD Project Understanding tubulin regulation during neuronal development, ageing and degeneration Axons are slender, up-to-a-meter long, cable-like extensions of neurons which form the nerves and nerve tracts that wire our bodies and brain. These delicate cellular structures have to be maintained for an organism’s life time and are[…]

Adhesion and signaling by Collagen IV intercellular concentrations (CIVICs)

Posted by on October 16th, 2017

The Great Wall of Collagen IV During the long history of evolution, the key innovation that gave rise to animals with true tissues was the extracellular matrix, very conserved from sponges to humans [1]. Before I started my PhD in the lab of Jose C. Pastor-Pareja at Tsinghua University in Beijing, he had described how[…]

Allometry in a Simple Cell Network

Posted by on September 19th, 2017

A post by Jasmin Imran Alsous, on work done in collaboration with Paul Villoutreix and Alexander M. Berezhkovskii in the Shvartsman lab. I started working on Drosophila egg chambers from the day I joined the Shvartsman lab. Egg chambers are small clusters of cells that eventually develop into mature oocytes in the abdomen of the female[…]

Internal mechanism found to be responsible for the limitless growth potential of epithelial tumours

Posted by on September 8th, 2017

Researchers from the Development and Growth Control Laboratory at IRB Barcelona have identified the cell types and molecular mechanism responsible for the unlimited growth potential of epithelial tumours (carcinomas) and demonstrated that the growth of these tumours is independent of its microenvironment. “In epithelial tumours caused by chromosomal instability or loss of cell polarity, the[…]

PhD position in cellular dynamics – Luschnig lab at University of Münster

Posted by on August 26th, 2017

  The Cluster of Excellence ”Cells in Motion“ (CiM) at the University of Münster invites applications for a   PhD student position (Salary Scale 13 TV-L / 65%) on   Cellular dynamics during epithelial morphogenesis in Drosophila   in the group of Prof. Stefan Luschnig at the Institute of Neurobiology. The position is available from[…]

Making time matter: how hormone pulses direct chromatin accessibility during development

Posted by on August 8th, 2017

Each of our cells has the same genetic information and thus the same potential to become a part of a heart, brain, or a finger. Somehow though, during development our cells manage to figure out exactly which type of cell they should be and which body parts they should help compose. The key to making[…]

Research assistant in Development Biology, Sheffield University

Posted by on August 3rd, 2017

A Wellcome Trust/Royal Society funded Research Assistant position is available in Dr Kyra Campbell’s research group. This is a fantastic opportunity to join the Campbell group, who are focused on identifying the molecular mechanisms underlying epithelial cell plasticity during development and disease. We study how this fundamental property is orchestrated during morphogenesis of the Drosophila[…]

The people behind the papers – Giri Dahal, Sarala Pradhan & Emily Bates

Posted by on August 2nd, 2017

Ion channels are famous for their roles in neurons and muscles, but the spectrum of phenotypes seen in ion channel mutants indicate a diversity of roles in development; the underlying mechanisms, however, have remained opaque. This week we feature a paper published in the latest issue of Development that reveals a link between potassium channels and morphogen[…]

The Drosophila fly brings to light the role of morphogens in limb growth

Posted by on July 5th, 2017

• Scientists at IRB Barcelona clarify the function of the genes that drive wing development in the fruit fly Drosophila melanogaster. • Published in the journal eLife, this study unveils that the Dpp morphogen is necessary for wing growth but that its gradient does not govern this process. • Understanding the development of limbs in[…]

Multiple stem cells, population asymmetry and position-dependent heterogeneity emerge as common features of a niche for Drosophila Follicle Stem Cells and mammalian Intestinal Stem Cells

Posted by on June 16th, 2017

A discussion of “Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling,” Nat Cell Biol, 2017. 19(5): p. 433-444.   We have recently revised the model of Follicle Stem Cell (FSC) organization in the Drosophila ovary, showing that there is a much larger population of stem cells than formerly realized, that[…]