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Displaying posts with the tag: limb-development [Clear Filter]

Hox genes: the key to decipher limb position – the story behind the paper

Posted by on February 6th, 2019

In our recent paper published in Current Biology, we unravel the direct and early role for Hox genes in the regulation and natural variation of the forelimb position in birds. Here I will share with you the story behind this paper. I have always been fascinated by the question of how, from a single cell,[…]

Of Arms and Legs: Shedding light onto developmental gene regulation

Posted by on November 19th, 2018

Written and illustrated by: Bjørt K. Kragesteen, Malte Spielmann, and Guillaume Andrey.   In early development, the forelimb and hindlimb buds of tetrapods are morphologically uniform. However, as limb development proceeds, each individual tissue attains a characteristic morphology that ultimately defines the identity of a forelimb (arm) or a hindlimb (leg). How do undifferentiated limbs[…]

Going out on a limb to study organ growth

Posted by on August 2nd, 2018

Alexandra Joyner and Alberto Roselló-Díez tell us the story behind their recent paper in PLoS Biology1.   Today we have tried a new experiment (we cannot help it). Instead of elaborating too much on the scientific aspect of our recent paper about the control of organ growth in mammals1, we decided to tell the personal[…]

Postdoctoral Position in Signaling Mechanisms

Posted by on October 25th, 2016

Postdoctoral Position open at: Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California   An NIH-funded postdoctoral position is available to investigate the signaling functions of retinoic acid (RA) during mouse embryo development. Our laboratory has reviewed recent advances in this field: Cunningham, T.J. and Duester, G. Mechanisms of retinoic acid signalling and its roles[…]

The people behind the papers: Joseph Pickering & Matthew Towers

Posted by on October 25th, 2016

So far in this series, we’ve featured fly nuclear pores, lizard tails, squid eyes and mouse digits, and heard from researchers working in Germany, the US and Canada. Today, we switch model system and geographical location once again. The work was published recently in Development, and uses timed inhibition of sonic hedgehog signalling during chick[…]

An interview with Cheryll Tickle

Posted by on April 5th, 2016

This interview first featured in Development.   Cheryll Tickle is an Emeritus Professor at the University of Bath, UK. She dedicated her long research career mainly to the study of limb development in the chick, and has received numerous awards for her contributions to science, including being elected a Fellow of The Royal Society and[…]

An interview with Lewis Wolpert

Posted by on August 4th, 2015

This interview first featured in Development.   Lewis Wolpert is a retired developmental biologist who, over his long career, has made many important contributions to the field, from his French Flag model and the concept of positional information to the famous quote that it is “not birth, marriage or death, but gastrulation which is truly the[…]

The science of the cat in your computer: our journey into crowdfunded sequencing of LilBUB

Posted by on April 27th, 2015

About a year ago – when spending some quality afterwork time on the Internet – me and my benchmate Dario stumbled upon LilBUB. If you’re an internet cat afficionado you’ve probably seen LilBUB around. She’s extremely cute and lovable, and she’s got something of a celebrity status. But, as developmental biologists, we were also intrigued by[…]