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Salah Elias introduces a new virtual forum for early PIs in cell and developmental biology

Posted by on June 29th, 2020

Of the many virtual seminar series that have sprung up in response to the COVID-19 pandemic, one in particular caught our eye – the New PIs in Cell and Developmental Biology Forum (you can follow updates and find information by following #NewPICellDev on Twitter). To find out more about the series we met Salah Elias,[…]

The people behind the papers – Charles Sheehan, John McMahon and Debby Silver

Posted by on May 27th, 2020

This interview, the 76th in our series, was published in Development earlier this year.  Interneurons are crucial to cortical function and their dysregulation has been implicated in various neurological pathologies, yet how they are generated during development is still poorly understood. A new paper in Development investigates interneuron neurogenesis in the mouse embryo and its[…]

The people behind the papers – Madeleine Linneberg-Agerholm, Yan Fung Wong and Josh Brickman

Posted by on February 20th, 2020

This interview, the 75th in our series, was recently published in Development.  Our understanding of lineage decisions in early human development has been greatly aided by embryonic stem cell lines, which avoid many of the practical and ethical difficulties of in vivo material. A new paper in Development exploits naïve human embryonic stem cells to generate in vitro models for the extra-embryonic[…]

The people behind the papers – Roman Szabo and Thomas Bugge

Posted by on January 29th, 2020

This interview, the 74th in our series, was recently published in Development.  Dysregulated activity of cell surface proteolytic enzymes has a wide range of developmental and pathological consequences, but the underlying mechanisms are often poorly understood. A new Development paper uses mice to model a severe inherited form of enteropathy and the role of the serine protease matriptase[…]

The people behind the papers – Daniel Osório, Elaine Chan, Joana Saramago and Ana Carvalho

Posted by on January 13th, 2020

This interview, the 73rd in our series, was recently published in Development.  Animal cytokinesis is driven by an actomyosin ring that assembles at the cell equator and constricts to physically separate the two daughters. Although myosin is known to be essential for cytokinesis in multiple systems, whether this requirement reflects its motor or actin crosslinking activities has[…]

The people behind the papers – Ding Li and Jianbo Wang

Posted by on November 29th, 2019

This interview, the 72nd in our series, was recently published in Development.  Heart development in mammals is a beautifully complex process. Patterning, proliferation and differentiation are all coordinated with cell movements and tissue morphogenesis (for instance elongation, fusion, folding, looping). However, our knowledge of the molecular regulators of heart development currently outstrips what we know about the[…]

The people behind the papers – George Britton and Aryeh Warmflash

Posted by on November 15th, 2019

This interview, the 71st in our series, was recently published in Development.  Our understanding of many fundamental aspects of early human development is still in its infancy, but a promising avenue for research uses advanced in vitro culturing techniques. For instance, confining human embryonic stem cells to micropatterned substrates and directing differentiation with signalling molecules has proved a powerful[…]

The people behind the papers – Mingxi Deng and Yan Yan

Posted by on November 7th, 2019

This interview, the 70th in our series, was recently published in Development.  Drosophila wing discs are epithelial sac-like organs and a powerful model for investigating the link between proliferation and patterning. Of particular interest is the question of how single cells in the disc integrate information regarding position and growth control, as morphogens that pattern an axis can[…]

The people behind the papers – Qiang Zhu, Marçal Gallemí and Eva Benková

Posted by on October 10th, 2019

This interview, the 69th in our series, was recently published in Development.  The apical hook is a transient structure that functions to protect the vulnerable apical meristem from damage when the seedling penetrates the soil. Although some of the molecular players regulating its development have been identified, many aspects have remained opaque, including how an early auxin[…]

The people behind the papers – Maurício Rocha-Martins and Mariana Silveira

Posted by on September 12th, 2019

This interview, the 68th in our series, was recently published in Development. See also the Press Release associated with the paper and also Brazilian newspaper Folha’s piece on the work  Retinal ganglion cells connect the retina to the brain, and their degeneration underlies glaucoma, which is the leading cause of irreversible blindness in humans and currently untreatable.[…]