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Displaying posts with the tag: zebrafish [Clear Filter]

New signal revealed for birth of blood stem cells in vertebrates

Posted by on March 1st, 2017

Jamie R. Genthe and Wilson K. Clements   When blood goes bad, a replacement is often needed. Each year, thousands of patients in the US receive bone marrow transplants to treat life-threatening diseases like blood cancer. But in some cases, the transplant itself can become deadly. The problem is not necessarily the one most people think[…]

Diversity is a good thing: coordination of collective cell migration in angiogenesis

Posted by on February 2nd, 2017

Comment on “Asymmetric division coordinates collective cell migration in angiogenesis” Nat Cell Bio, 18 (12), 1292-1301, (2016).   Holly E. Lovegrove & Guilherme Costa Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, Uk   Collective cell migration is involved in many biological processes. In particular it is required to build new tissues[…]

The tale of three cities – Valdivia, Jyväskylä and London

Posted by on January 23rd, 2017

This is the latest dispatch from a recipient of a Company of Biologists Travelling Fellowship. Learn more about the scheme, including how to apply, here, and read more stories from the Fellows here. Hanna Hakkinen   I am originally a Finnish evolutionary biology student who got fascinated about developmental biology during my exchange programme couple of[…]

The people behind the papers #6

Posted by on November 29th, 2016

Today’s paper comes from the latest issue of Development, and reveals a link between phenotypic variability, cell fate switching and epigenetic silencing in zebrafish. Lead author James T. Nichols, who carried out the work in Charles Kimmel’s lab in Euegene, Oregon and is now an Assistant Professor in UC Denver’s School of Dental Medicine, gave us the story behind[…]

Postdoctoral position in muscle biology

Posted by on October 18th, 2016

Postdoctoral position in muscle biology At the Dept of Clinical Sciences, Umeå University, Sweden Project description: The selected candidate will work within the research project ”The molecular portfolio of the extraocular muscles”, led by Professor Fatima Pedrosa Domellöf at the Departments of Clinical Sciences at Umeå University, Sweden. The actual research project explores i) how[…]

Where does blood come from in the first place and how is it made?

Posted by on September 14th, 2016

Commentary on Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells in Developmental Cell, Volume 38, Issue 4, p358–370, 22 August 2016   Each of us has around 6 pints of blood. The blood contains a number of different types of cells, including oxygen-transporting red blood cells, disease-protecting white[…]

FaceBase: An online resource for craniofacial research

Posted by on August 16th, 2016

In 2009, FaceBase was launched in response to the need for more comprehensive analysis of craniofacial development: with so much craniofacial data being generated, there is a danger of relevant datasets being buried in the avalanche of genomic and other data. FaceBase is a curated, one-stop shop for facial development and research offering the community input and[…]

The Doctor of Delayed Publications – the remarkable life of George Streisinger

Posted by on July 21st, 2016

It seemed like an ordinary morning, with the lecture on Drosophila genetics due to start at 8 o’clock. But when the professor walked in something remarkable happened: instead of starting the lecture right away, he posed an unusual question: “One of the students of this class has a publication on this topic. George Streisinger, where[…]

Sweetening with a pinch of salt: maximized Cas9 efficiency in zebrafish

Posted by on June 14th, 2016

  Alexa Burger, Mosimann lab, Institute of Molecular Life Sciences, University of Zürich, Switzerland. When I first heard about the “new” genome editing method in early 2013 called CRISPR-Cas9, I thought: “Never ever again will I work with targeted nucleases!” Now it’s mid-2016, we published our approaches to maximize Cas9 effectiveness in zebrafish with Development[…]

Scratching the surface of a rainbow

Posted by on April 26th, 2016

  Why some vertebrates like salamanders and zebrafish are able to regenerate complex tissues while humans cannot is a question that has fascinated biologists for centuries. Understanding how and why regeneration occurs in these animals can inspire novel treatment strategies for regenerative medicine. At the cellular level, the regeneration process is driven by dynamic activities[…]