In Development this week (Vol. 144, Issue 6) – SPECIAL ISSUE ON ORGANOIDS

The current issue of Development – our Special Issue on Organoids – features a collection of review- and research-based articles focusing on organoids. Here are some of the highlights. Happy reading (and thanks to everyone who contributed)!

Organoids: a Special Issue

In her Editorial, Melissa Little provides an overview of the entire contents of the Special Issue, highlighting some of the important findings and major themes therein.

The hope and the hype of organoid research

In their Spotlight article, Meritxell Huch and Juergen Knoblich, together with Matthias Lutolf and Alfonso Martinez-Arias, discuss the exciting promise of organoid technology, as well as the current limitations and what it will take to overcome them.

Ethical issues in human organoid and gastruloid research

Megan Munsie, Insoo Hyun and Jeremy Sugarman summarize some of the important ethical issues associated with research involving human organoids and other complex self-organized structures. Read their Spotlight article.

The physics of organoids: a biophysical approach to understanding organogenesis

Svend Dahl-Jensen and Anne Grapin-Botton highlight some interesting applications of physics in organoid research, from computational modeling of organoid biology to understanding mechanical aspects of organ development. Read their Spotlight article.

Using brain organoids to understand Zika virus-induced microcephaly

In their Spotlight article, Hongjun Song, Guo-li Ming and colleagues summarise the latest advances in using cerebral organoids to model Zika virus infection and the resulting pathology. 

Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish

This Development at a Glance poster article by Heather McCauley and James Wells summarises how knowledge gained from developmental biology can be used to guide human in vitro organogenesis, and discusses the potential applications of this technology.

Translational applications of adult stem cell-derived organoids

Jarno Drost and Hans Clevers discuss how adult stem cell-derived organoids can be used to model human diseases, create personalized cancer therapies and further efforts in regenerative medicine. Read the Primer article.

Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis

In their Review article, Mijo Simunovic and Ali Brivanlou discuss the basic physical and biological principles that underlie the self-organization of embryonic stem cells into organoids, and how this informs human development.

Lung organoids: current uses and future promise

Brigid Hogan and colleagues explore the latest advances in both adult and embryonic stem cell-derived lung organoid culture, and discuss how these systems can be used to understand homeostasis and regeneration. Read their Review.

Dissecting the stem cell niche with organoid models: an engineering-based approach

In their Review, Zev Gartner and co-workers highlight how organoids have been used to model and characterize stem cell-niche interactions and how new engineering approaches enable systematic study of the stem cell niche.

PLUS:

This Special Issue also contains a number of Research Reports, Research Articles and Techniques & Resources Articles – click here for a full listing!

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