Post-doc position at the NIH: New mechanisms of WNT/R-spondin signaling in development and stem cells

Position Description:

We seek highly motivated post-doctoral Fellows interested in cell signaling at the intersection of development, stem cells and cancer. Candidates will join the group of Dr. Andres Lebensohn, an Earl Stadtman Principal Investigator in the Laboratory of Cellular and Molecular Biology (LCMB) at the Center for Cancer Research (CCR) of the National Cancer Institute (NCI), National Institutes of Health (NIH). We combine functional genomics, CRISPR/Cas9-mediated genome editing, cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development, and maintain them in adult life. A major focus of the lab is on WNT/R-spondin signaling, a fundamental pathway that orchestrates embryonic patterning and morphogenesis, and promotes stem cell self-renewal and tissue regeneration. We recently discovered a new mode of signaling by R-spondins that does not require LGRs, thought to be the main R-spondin receptors (https://elifesciences.org/articles/33126). We seek a Fellow who will use mouse genetics to elucidate the physiological functions of LGR-independent signaling by R-spondins during embryonic development and in stem cells. Descriptions of this and other research projects in the lab can be found at https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/andres-m-lebensohn.

About the Center for Cancer Research and the Laboratory of Cellular and Molecular Biology:

The CCR is the largest division of the NCI intramural research program, comprising nearly 250 basic and clinical research groups. In the words of Dr. Tom Misteli, director of the CCR, “Our scientists enjoy complete intellectual freedom and are expected to creatively and innovatively explore the most important questions in the field of cancer research and treatment.” The LCMB (https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology) is located at the NIH Bethesda campus within a vibrant biomedical research community. We have access to state-of-the art research facilities and close links to the NIH Clinical Center, one of the leading clinical research hospitals in the world. The open lab space, collegial atmosphere and joint weekly seminars shared by the seven groups in the LCMB give Fellows a strong support network and plenty of opportunities to present and discuss their research with close peers. A short metro ride to Washington D.C. and the surrounding areas provides Fellows and their families access to numerous free museums (https://washington.org/free-things-to-do), excellent culinary choices and many outdoor activities.

Qualifications:

Candidates must have completed a Ph.D. and should be recent graduates or have less than 3 years of post-doctoral experience by the desired start date. Candidates with backgrounds in developmental, stem cell or cancer biology are encouraged to apply. Experience in mouse genetics is required for this project, and experience with organoid models is welcome but not required. Fellows will have exceptional stipend support for the entire duration of their post-doctorate, funds for travel to scientific conferences, and full healthcare benefits.

How to Apply:

Please send a cover letter describing your research accomplishments and future interests, including your specific interest in my lab, a CV with bibliography, and contact information for three references to andres.lebensohn@nih.gov. Please use the following email subject: “Application for post-doc position in WNT/R-spondin signaling”

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