Postdoctoral Position in Epigenetics and Pluripotency @ Babraham Institute, Cambridge, UK

The central aim of this three-year project is to investigate new regulators of human naïve cell reprogramming that we have recently identified, and to develop a mechanistic understanding of how they function. The job holder will engineer human pluripotent cell lines with inducible degradation systems targeting the identified regulators and will use these cell lines to investigate the molecular and cellular defects that arise following protein degradation. The job holder will also use CUT&Tag methods to identify genome-wide occupancy of the proteins of interest. We have particular expertise in reprogramming and capacitation transitions, developmental cell models including gastruloids, gene targeting, and in relevant assays such as proteomics and single cell transcriptomics / epigenomics. The overall significance of this work will be to establish exciting new links between gene regulatory mechanisms and the control of pluripotency during human development. We anticipate that modulating the identified pathways will improve the generation of naïve cells and open up new ways to deliver cell types with useful translational properties.

The ideal candidate will be interested in stem cell and developmental biology, particularly in the gene regulatory mechanisms that underpin lineage specification and reprogramming. The Epigenetics Programme provides a highly collaborative and thriving research environment with particular strengths in stem cell, developmental and ageing biology. We have access to onsite state-of-the-art facilities run by dedicated staff, including High-Throughput Sequencing, Bioinformatics, Imaging and Gene Targeting. We have close links to Cambridge University through affiliations with the Stem Cell Institute, the Centre for Trophoblast Research, the Epigenetics Club, and with the many departments and companies that we work with.

Please see: https://www.babraham.ac.uk/vacancies-training for a full job specification and also links to the application form. The application deadline is 15th March 2021.