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Research Highlight #4: Macrophages in human development

Posted by on June 1st, 2020

Today we return our interest to human development, focusing on a special blood cell: the macrophage. Produced in multiple, stem cell-independent waves, macrophages colonize the developing foetus early on, forming several tissue-resident populations. This includes the microglia which are essential for brain and spinal cord development. In this paper, the authors looked into macrophage development[…]

POSTDOCTORAL RESEARCHER

Posted by on February 27th, 2020

Kuure lab, affiliated with STEMM research program at Research Programs Unit of the Faculty of Medicine and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, invites applications for a position of POSTDOCTORAL RESEARCHER IN FinnDisMice PROJECT for a two-year fixed term position (possibility for extension) starting as soon as possible. Trial period of six[…]

The people behind the papers – Madeleine Linneberg-Agerholm, Yan Fung Wong and Josh Brickman

Posted by on February 20th, 2020

This interview, the 75th in our series, was recently published in Development.  Our understanding of lineage decisions in early human development has been greatly aided by embryonic stem cell lines, which avoid many of the practical and ethical difficulties of in vivo material. A new paper in Development exploits naïve human embryonic stem cells to generate in vitro models for the extra-embryonic[…]

The people behind the papers – George Britton and Aryeh Warmflash

Posted by on November 15th, 2019

This interview, the 71st in our series, was recently published in Development.  Our understanding of many fundamental aspects of early human development is still in its infancy, but a promising avenue for research uses advanced in vitro culturing techniques. For instance, confining human embryonic stem cells to micropatterned substrates and directing differentiation with signalling molecules has proved a powerful[…]

Two Postdoctoral Positions (Experimental & Bioinformatician) @ Babraham Institute

Posted by on October 15th, 2019

We are seeking to recruit two talented and highly motivated Postdoctoral Research Scientist to investigate the molecular regulation of lineage specification during the development of human preimplantation embryos. One position is for an experimental researcher and one position is for a bioinformatician. These new posts are part of the exciting Wellcome-funded Human Developmental Biology Initiative[…]

Development Special Issue: The Origins and Mechanisms of Developmental Disorders

Posted by on October 3rd, 2019

Development invites you to submit your latest research for our upcoming special issue: The Origins and Mechanisms of Developmental Disorders. This issue will be coordinated by two guest editors: Sally Dunwoodie and John Wallingford. Developmental disorders are among the most lethal diseases of childhood, and this recent decade has witnessed significant advances in our understanding of their genetic and environmental[…]

Harvard / Mass General recruiting post-doc fellow to study craniofacial developmental genetics, using human iPSC, mouse and zebrafish models.

Posted by on May 1st, 2019

Job Title: Post-doctoral fellow.  Position is currently recruiting.  Minimum of 2-year commitment is required.   Job Description The Liao Laboratory at the Center for Regenerative Medicine at Massachusetts General Hospital in affiliation with the Division of Plastic Surgery and the Harvard Stem Cell Institute is seeking a highly motivated research fellow interested in craniofacial developmental biology[…]

The reported birth of CRISPR-edited humans: reactions from the field

Posted by on November 29th, 2018

One scientific story has dominated the news this week: the first report of CRISPR-edited human babies being born. In an associated Node post, we’ve collected the most useful links we could find surrounding the story, and here we reached out to members of the community for their perspectives. Some responses are hopefully still coming in[…]

The reported birth of CRISPR-edited humans: useful links

Posted by on November 29th, 2018

One scientific story has dominated the news this week: the first report of CRISPR-edited human babies being born. The story’s scientific and ethical aspects stirred up heated debate, as did its means of delivery: rather than a published paper, the story broke with reports of clinical trial documents and then a YouTube video from lead[…]

Of Arms and Legs: Shedding light onto developmental gene regulation

Posted by on November 19th, 2018

Written and illustrated by: Bjørt K. Kragesteen, Malte Spielmann, and Guillaume Andrey.   In early development, the forelimb and hindlimb buds of tetrapods are morphologically uniform. However, as limb development proceeds, each individual tissue attains a characteristic morphology that ultimately defines the identity of a forelimb (arm) or a hindlimb (leg). How do undifferentiated limbs[…]