Welcome to our monthly trawl for developmental biology (and related) preprints. 

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This month was notable for a preponderance of plant development preprints, many molecular maps (supported by single cell sequencing), a hearty helping of human development and a multiplicity of (Drosophila) melanogaster mechanics.

The preprints were hosted on bioRxiv, PeerJ, and arXiv. Let us know if we missed anything, and use these links to get to the section you want:

 

Developmental biology

| Patterning & signalling

| Morphogenesis & mechanics

| Genes & genomes

| Stem cells, regeneration & disease modelling

| Plant development

Evo-devo & evo

Cell biology

Modelling

Tools & resources

Research practice & education

Why not…

 

 

Developmental biology

| Patterning & signalling

 

 

The role of lineage, hemilineage and temporal identity in establishing neuronal targeting and connectivity in the Drosophila embryo
Brandon Mark, Sen-Lin Lai, Aref Arzan Zarin, Laurina Manning, Albert Cardona, James W. Truman, Chris Q. Doe

 

A Drosophila larval premotor/motor neuron connectome generating two behaviors via distinct spatio-temporal muscle activity
Aref Arzan Zarin, Brandon Mark, Albert Cardona, Ashok Litwin-Kumar, Chris Q. Doe

 

Hairless as a novel component of the Notch signaling pathway
Steven W Miller, Artem Movsesyan, Sui Zhang, Rosa Fernández, James W Posakony

 

The Role of Sevenless in Drosophila R7 Photoreceptor Specification
Andrew Tomlinson, Yannis Emmanuel Mavromatakis, Ronald Arias

 

Multimodal transcriptional control of pattern formation in embryonic development
Nicholas C Lammers, Vahe Galstyan, Armando Reimer, Sean A Medin, Chris H Wiggins, Hernan G Garcia

 

Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation
Annabelle Dold, Hong Han, Niankun Liu, Andrea Hildebrandt, Mirko Brüggemann, Cornelia Rücklé, Anke Busch, Petra Beli, Kathi Zarnack, Julian König, Jean-Yves Roignant, Paul Lasko

 

Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila
Juan A. Sanchez, Duarte Mesquita, María C. Ingaramo, Federico Ariel, Marco Milán, Andrés Dekanty

 

Drosophila insulin-like peptide 1 (DILP1) promotes organismal growth and catabolic energy metabolism during the non-feeding pupal stage
Sifang Liao, Stephanie Post, Philipp Lehmann, Jan A Veenstra, Marc Tatar, Dick R Nassel

 

Differential Metabolic Sensitivity of mTORC1- and mTORC2-Dependent Overgrowth
Maelle Devilliers, Damien Garrido, Mickael Poidevin, Thomas Rubin, Arnaud Le Rouzic, Jacques Montagne

 

Drosophila adult muscle precursor cells contribute to motor axon pathfinding and proper innervation of embryonic muscles
Guillaume Lavergne, Krzysztof Jagla

 

Yorkie and JNK revert syncytial muscles into myoblasts during Org-1 dependent lineage reprogramming
Christoph Schaub, Marcel Rose, Manfred Frasch

 

 

Induction of Chk2 signaling in the germarium is sufficient to cause oogenesis arrest in Drosophila
Zeljko Durdevic, Anne Ephrussi

 

Trans-synaptic Fish-lips Signaling Prevents Misconnections between Non-synaptic Partner Olfactory Neurons
Qijing Xie, Bing Wu, Jiefu Li, Hongjie Li, David J Luginbuhl, Chuanyun Xu, Xin Wang, Liqun Luo

 

Altered levels of hsromega lncRNAs further enhance Ras signaling during ectopically activated Ras induced R7 differentiation in Drosophila
Mukulika Ray, Gunjan Singh, Subhash C. Lakhotia

 

A direct glia-to-neuron natural transdifferentiation ensures nimble sensory-motor coordination of male mating behaviour
Laura Molina-Garcia, Byunghyuk Kim, Steven J Cook, Rachel Bonnington, Jack O’Shea, Michele Sammut, Sophie P R Gilbert, David Elliott, David H Hall, Scott W Emmons, Arantza Barrios, Richard J Poole

 

Epigenetic bookmarking of H2S exposure in Caenorhabditis elegans
Emily M Fawcett, Jenna K Johnson, Chris Braden, Esteli M Garcia, Dana L Miller

 

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans
Xiong Wang, Lin Zhang, Lei Zhang, Wenli Wang, Sihan Wei, Jie Wang, Huilian Che, Yali Zhang

 

 

Zebrafish GPR161 Contributes to Basal Hedgehog Repression in a Tissue-specific Manner
Philipp Tschaikner, Dominik Regele, Willi Salvenmoser, Stephan Geley, Eduard Stefan, Pia Aanstad

 

GABA-A signaling maintains melanocyte stem cell quiescence in larval zebrafish
James R. Allen, James B. Skeath, Stephen L. Johnson

 

 

Integrated K+ channel and K+-Cl− cotransporter functions regulate fin proportionality in zebrafish
Jennifer S. Lanni, David Peal, Laura Ekstrom, Haining Chen, Caroline Stanclift, Margot Bowen, Adriana Mercado, Gerardo Gamba, Kristopher T. Kahle, Matthew P. Harris

 

Large-scale death of retinal astrocytes during normal development mediated by microglia
Vanessa M. Puñal, Caitlin E. Paisley, Federica S. Brecha, Monica A. Lee, Robin M. Perelli, Emily G. O’Koren, Caroline R. Ackley, Daniel R. Saban, Benjamin E. Reese, Jeremy N. Kay

 

A combination of running and memantine increases neurogenesis and reduces activation of developmentally-born dentate granule neurons in rats
Shaina P. Cahill, Angela Martinovic, John Darby Cole, Jason S. Snyder

 

 

Mapping cell migrations and fates from a gastruloid model to the human primitive streak
I. Martyn, E.D. Siggia, A.H. Brivanlou

 

 

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development
Ewoud R.E. Schmidt, Justine V. Kupferman, Michelle Stackmann, Franck Polleux

 

ERK1/2 signalling dynamics promote neural differentiation by regulating the polycomb repressive complex
Claudia I. Semprich, Vicki Metzis, Harshil Patel, James Briscoe, Kate G. Storey

 

 

Cyclin B3 is dispensable for mouse spermatogenesis
Mehmet E. Karasu, Scott Keeney

 

Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function
Mroj Alassaf, Emily Daykin, Jaffna Mathiaparanam, Marc Wolman

 

Dorsal-to-ventral neocortical expansion is physically primed by ventral streaming of early embryonic preplate neurons
Kanako Saito, Mayumi Okamoto, Yuto Watanabe, Namiko Noguchi, Arata Nagasaka, Yuta Nishina, Tomoyasu Shinoda, Akira Sakakibara, Takaki Miyata

 

Canonical NOTCH signaling controls the early progenitor state and emergence of the medullary epithelial lineage in fetal thymus development
Dong Liu, Anastasia I. Kousa, Kathy E. O’Neill, Francois Guillemot, Martyna Popis, Alison M. Farley, Simon R. Tomlinson, Svetlana Ulyanchenko, Philip A. Seymour, Palle Serup, Ute Koch, Freddy Radtke, C. Clare Blackburn

 

NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development
Jie Li, Julie Gordon, Edward L. Y. Chen, Luying Wu, Juan Carlos Zúñiga-Pflücker, Nancy R. Manley

 

Apoptosis in the fetal testis eliminates developmentally defective germ cell clones
Daniel H. Nguyen, Diana J. Laird

 

RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2
Barbara Nicol, Sara A. Grimm, Frederic Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao

 

Chemically-defined induction of a primitive endoderm and epiblast-like niche supports post-implantation progression from blastoids
Erik J. Vrij, Yvonne S. Scholte op Reimer, Javier Frias Aldeguer, Isabel Misteli Guerreiro, Jop Kind, Bon-Kyoung Koo, Clemens A. van Blitterswijk, Nicolas C. Rivron

 

N-Glycome regulation limits the transdifferentiation of endothelial cells into hematopoietic stem cells
Dionna M. Kasper, Yinyu Wu, Hanna K. Mandl, Kevin Salinas, Joey Ghersi, Jared Hintzen, William Armero, Zhiheng He, Daniel W. Heindel, Eon Joo Park, William C. Sessa, Lara K. Mahal, Karen K. Hirschi, Stefania Nicoli

 

Loss of adipocyte identity through synergistic repression of PPARγ by TGF-β and mechanical stress
Ewa Bielczyk-Maczyńska, Brooks Taylor, Cayla M Miller, Michael L Zhao, Arnav Shah, Zahra Bahrami-Nejad, Alexander R Dunn, Mary N Teruel

 

Greater loss of female embryos during human pregnancy: A novel mechanism
John F Mulley

 

 

Complement in human pre-implantation embryos: attack and defense
Martin P. Reichhardt, Karolina Lundin, A. Inkeri Lokki, Gaëlle Recher, Sanna Vuoristo, Shintaro Katayama, Juha Tapanainen, Juha Kere, Seppo Meri, Timo Tuuri

 

 

Alternative pathway androgen biosynthesis and human fetal female virilization
Nicole Reisch, Angela E Taylor, Edson F Nogueiras, Daniel J Asby, Vivek Dhir, Andrew Berry, Nils P Krone, Richard J Auchus, Cedric HL Shackleton, Neil A Hanley, Wiebke Arlt

 

Longitudinal white matter development in children is associated with puberty, attentional difficulties, and mental health
Sila Genc, Charles B Malpas, Alisha Gulenc, Emma Sciberras, Daryl Efron, Timothy J Silk, Marc L Seal

 

Slc7a11 modulated by POU2F1 is involved in pigmentation in rabbit
Yang Chen, Shuaishuai Hu, Lin Mu, Bohao Zhao, Manman Wang, Naisu Yang, Guolian Bao, Cigen Zhu, Xinsheng Wu

 

Androgen-dmrt1 positive feedback programs the rice field eel (Monopterus albus) sex transdifferentiation
Bin Wen, Xiancheng Qu, Lisha Pan, Jianzhong Gao, Haowei Wu, Qian Wang

 

Nix confers heritable sex-conversion in Aedes aegypti and myo-sex is needed for male flight
Azadeh Aryan, Michelle Anderson, James K. Biedler, Yumin Qi, Justin M. Overcash, Anastasia N. Naumenko, Maria V. Sharakhova, Chunhong Mao, Zach N. Adelman, Zhijian Tu

 

 

| Morphogenesis & mechanics

The Drosophila Afadin and ZO-1 homologs Canoe and Polychaetoid act in parallel to maintain epithelial integrity when challenged by adherens junction remodeling
Lathiena Manning, Kia Perez-Vale, Kristina Schaefer, Mycah Sewell, Mark Peifer

 

 

Rho-kinase planar polarisation at tissue boundaries depends on phospho-regulation of membrane residence time
Clara Sidor, Tim J. Stevens, Li Jin, Jérôme Boulanger, Katja Röper

 

The RhoGEF Cysts couples apical polarity proteins to Rho and myosin activity at adherens junctions
Jordan T. Silver, Frederik Wirtz-Peitz, Sérgio Simões, Milena Pellikka, Dong Yan, Richard Binari, Takashi Nishimura, Yan Li, Tony J. C. Harris, Norbert Perrimon, Ulrich Tepass

 

 

A fence function for adherens junctions in epithelial cell polarity
Mario Aguilar-Aragon, Alex Tournier, Barry J Thompson

 

Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import, stability and phase separation
Clara Sidor, Nerea Borreguero-Munoz, Georgina C Fletcher, Ahmed Elbediwy, Hannah Vanyai, Oriane Guillermin, Barry J Thompson

 

Tissue specific vulnerability to mitotic defects caused by mutations in the Drosophila ASPM homologue, Asp
Lori Borgal, Margaux Quiniou, James Wakefield

 

Tissue Mechanics Determines Cell Fate in the Axial Stem Zones
Timothy R Wood, Anders R Kyrsting, Johannes Stegmaier, Iwo Kucinski, Clemens F Kaminski, Ralf Mikut, Octavian Voiculescu

 

 

Osteocytes remodel bone by TGF-β-induced YAP/TAZ signaling
Christopher D. Kegelman, Jennifer C. Coulombe, Kelsey M. Jordan, Daniel J. Horan, Ling Qin, Alexander G. Robling, Virginia. L Ferguson, Teresita M. Bellido, Joel D. Boerckel

 

The desmosomal cadherin Desmogon is necessary for the structural integrity of the Medaka notochord
Ali Seleit, Karen Groß, Michaela Wölk, Camilla Autorino, Lazaro Centanin

 

 

Suppression of transcytosis regulates zebrafish blood-brain barrier development
Natasha M. O’Brown, Sean G. Megason, Chenghua Gu

 

Segregated neural explants exhibit co-oriented, asymmetric, neurite outgrowth
David B. Pettigrew, Curtis B. Dobson, Lori G. Isaacson, Eric Leuthardt, Heather Lilley, Georgette Suidan, Keith A. Crutcher

 

 

| Genes & genomes

 

Developmentally regulated Shh expression is robust to TAD perturbations
Iain Williamson, Lauren Kane, Paul S Devenney, Eve Anderson, Fiona Kilanowski, Robert E Hill, Wendy Bickmore, Laura Lettice

 

In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation
Daniel Andergassen, Zachary D. Smith, Jordan P. Lewandowski, Chiara Gerhardinger, Alexander Meissner, John L. Rinn

 

Developmentally regulated tcf7l2 splice variants mediate transcriptional repressor functions during eye formation
Rodrigo M. Young, Kenneth B. Ewan, Veronica P. Ferrer, Miguel L. Allende, Trevor C. Dale, Stephen W. Wilson

 

 

Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry
Ingrid Lekk, Véronique Duboc, Ana Faro, Stephanos Nicolaou, Patrick Blader, Stephen W. Wilson

 

miR-9 mediated noise optimization of the her6 oscillator is needed for cell state progression in the Zebrafish hindbrain
Ximena Soto, Veronica Biga, Jochen Kursawe, Robert Lea, Parnian Doostdar, Nancy Papalopulu

 

Epigenetic regulation of unique genes and repetitive elements by the KRAB zinc finger protein ZFP57
Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger, Anne C. Ferguson-Smith

 

 

FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
Ryan J Kast, Alexandra L Lanjewar, Colton D Smith, Pat Levitt

 

A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle
Glenda Comai, Églantine Heude, Sebastien Mella, Sylvain Paisant, Francesca Pala, Mirialys Gallardo, Gabrielle Kardon, Swetha Gopalakrishnan, Shahragim Tajbakhsh

 

Single-cell analysis of Foxp1-driven mechanisms essential for striatal development
Ashley G. Anderson, Ashwinikumar Kulkarni, Matthew Harper, Genevieve Konopka

 

 

A Single-cell Transcriptomic Atlas of the Developing Chicken Limb
Christian Feregrino, Fabio Sacher, Oren Parnas, Patrick Tschopp

 

A 3D molecular atlas of the chick embryonic heart
Claire Anderson, Bill Hill, Hui-Chun Lu, Adam Moverley, Youwen Yang, Nidia M.M. Oliveira, Richard A. Baldock, Claudio D. Stern

 

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium
Katherine C. Goldfarbmuren, Nathan D. Jackson, Satria P. Sajuthi, Nathan Dyjack, Katie S. Li, Cydney L. Rios, Elizabeth G. Plender, Michael T. Montgomery, Jamie L. Everman, Eszter K. Vladar, Max A. Seibold

 

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina
Jixing Zhong, Dongsheng Chen, Fangyuan Hu, Fang Chen, Zaoxu Xu, Jian Fang, Jianjiang Xu, Shiyou Wang, Langchao Liang, Chaochao Chai, Xiangning Ding, Jiacheng Zhu, Peiwen Ding, Jun Xia, Sanjie Jiang, Wei Li, Ya Gao, Jianguo Zhang, Jiankang Li, Ping Xu, Fengjuan Gao, Dandan Wang, Daowei Zhang, Jie Huang, Shoufang Qu, Shenghai Zhang, Jihong Wu, Xinghuai Sun

 

GPIF constrains Polycomb Repressive Complex 2 activity in germ cells
R Ragazzini, R Pérez-Palacios, HI Baymaz, D Zielinski, A Michaud, M Givelet, M Borsos, PWTC Jansen, N Servant, ME Torres-Padilla, D Bourc’his, P Fouchet, M Vermeulen, R Margueron

 

Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan
Julien Rougeot, Naomi D. Chrispijn, Marco Aben, Dei M. Elurbe, Karolina M. Andralojc, Patrick J. Murphy, Pascal W.T.C. Jansen, Michiel Vermeulen, Bradley R. Cairns, Leonie M. Kamminga

 

FGF/MAPK signaling pathway regulates the genome-wide occupancy of Polycomb Repressive Complex 2 in murine embryonic stem cells
Mohammad B. Aljazi, Yuen Gao, Yan Wu, George I. Mias, Jin He

 

PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants by regulating histone modification
Ravindra S. Prajapati, Mark Hintze, Andrea Streit

 

 

Regardless of the deposition pathway, aminoacid 31 in histone variant H3 is essential at gastrulation in Xenopus
David Sitbon, Ekaterina Boyarchuk, Geneviève Almouzni

 

Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout mice
Jiaxi Chen, Zhipeng Su, Chunlei Zhang, Fenge Li, Patrick Hwu, Zhen Wang, Yanping Wang, Yunsen Li, Jiao Tong, Chunchao Chen, Dapeng Zhou

 

Telomere dysfunction represses HNF4α leading to impaired hepatocyte development and function
Evandro L. Niero, Wilson C. Fok, Alexandre T. Vessoni, Kirsten A. Brenner, Luis F.Z. Batista

 

A network of microRNAs acts to promote cell cycle exit and differentiation of human pancreatic endocrine cells
Wen Jin, Francesca Mulas, Bjoern Gaertner, Yinghui Sui, Jinzhao Wang, Chun Zeng, Nicholas Vinckier, Allen Wang, Kim-Vy Nguyen-Ngoc, Joshua Chiou, Klaus H. Kaestner, Kelly Frazer, Andrea C. Carrano, Hung-Ping Shih, Maike Sander

 

Developmental and cell-specific expression of Cacna1d splice variants
LaCarubba Brianna, Bunda Alexandra, Savage Kitty, Sargent Hannah, Akiki Marie, Foxall Thomas, Andrade Arturo

 

 

Spatio-temporal analysis of human preimplantation development reveals dynamics of epiblast and trophectoderm
Dimitri Meistermann, Sophie Loubersac, Arnaud Reignier, Julie Firmin, Valentin Francois Campion, Stéphanie Kilens, Yohann Lelièvre, Jenna Lammers, Magalie Feyeux, Phillipe Hulin, Steven Nedellec, Betty Bretin, Simon Covin, Gael Castel, Audrey Bihouée, Magali Soumillon, Tarjei Mikkelsen, Paul Barrière, Jérémie Bourdon, Thomas Fréour, Laurent David

 

The RNA binding protein DAZL functions as repressor and activator of maternal mRNA translation during oocyte maturation
Cai-Rong Yang, Gabriel Rajkovic, Enrico Maria Daldello, Xuan G. Luong, Jing Chen, Marco Conti

 

Chromatin co-accessibility is highly structured, spans entire chromosomes, and mediates long range regulatory genetic effects
William W. Young Greenwald, Agnieszka D’Antonio-Chronowska, Paola Benaglio, Hiroko Matsui, Erin N. Smith, Matteo D’Antonio, Kelly A. Frazer

 

CTCF binding strength modulates chromatin architecture through the changes of the local nucleosome repeat length
Christopher T. Clarkson, Emma A. Deeks, Ralph Samarista, Victor B. Zhurkin, Vladimir B. Teif

 

Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2
Filippo M. Cernilogar, Stefan Hasenöder, Zeyang Wang, Katharina Scheibner, Ingo Burtscher, Michael Sterr, Pawel Smialowski, Sophia Groh, Ida M. Evenroed, Gregor D. Gilfillan, Heiko Lickert, Gunnar Schotta

 

Stochastic gene expression is optimized to drive developmental self-organization
Ritika Giri, Dimitrios K. Papadopoulos, Diana M. Posadas, Hemanth K. Potluri, Pavel Tomancak, Madhav Mani, Richard W. Carthew

 

The histone demethylase KDM5 controls developmental timing in Drosophila by promoting prothoracic gland endocycles
Coralie Drelon, Helen M. Belalcazar, Julie Secombe

 

Polymer coil-globule phase transition is a universal folding principle of Drosophila epigenetic domains
Antony Lesage, Vincent Dahirel, Jean-Marc Victor, Maria Barbi

 

RNA transcribed from heterochromatic simple-tandem repeats are required for male fertility and histone-protamine exchange in Drosophila melanogaster
Wilbur K Mills, Yuh Chwen G. Lee, Antje M Kochendoerfer, Elaine M Dunleavy, Gary H. Karpen

 

BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila
Malin Ueberschär, Huazhen Wang, Chun Zhang, Shu Kondo, Tsutomu Aoki, Paul Schedl, Eric C. Lai, Jiayu Wen, Qi Dai

 

Elav-mediated exon skipping and alternative polyadenylation of the Dscam1 gene is required for axon outgrowth
Z. Zhang, K. So, R. Peterson, M. Bauer, H. Ng, Y. Zhang, J.H. Kim, T. Kidd, P. Miura

 

Drosophila ribosomal protein S5b is essential for oogenesis and interacts with distinct RNAs
Jian Kong, Hong Han, Julie Bergalet, Louis Philip Benoit Bouvrette, Greco Hernández, Nam-Sung Moon, Hojatollah Vali, Éric Lécuyer, Paul Lasko

 

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
Julia Batki, Jakob Schnabl, Juncheng Wang, Dominik Handler, Veselin I. Andreev, Christian E. Stieger, Maria Novatchkova, Lisa Lampersberger, Kotryna Kauneckaite, Wei Xie, Karl Mechtler, Dinshaw J. Patel, Julius Brennecke

 

 

piRNA-guided co-transcriptional silencing coopts nuclear export factors
Martin H. Fabry, Filippo Ciabrelli, Marzia Munafò, Evelyn L. Eastwood, Emma Kneuss, Ilaria Falciatori, Federica A. Falconio, Gregory J. Hannon, Benjamin Czech

 

Effect of heritable symbionts on maternally-derived embryo transcripts
Mariana Mateos, Nadisha O. Silva, Paulino Ramirez, Victor M. Higareda-Alvear, Rodolfo Aramayo, James W. Erickson

 

Binding of an X-specific condensin correlates with a reduction in active histone modifications at gene regulatory elements
Lena Annika Street, Ana Karina Morao, Lara Heermans Winterkorn, Chen-Yu Jiao, Sarah Elizabeth Albritton, Mohammed Sadic, Maxwell Kramer, Sevinç Ercan

 

The knockout of the HMG-Box Domain of the porcine SRY-gene by CRISPR/Cas RNP microinjection causes sex reversal in gene-edited pigs
Stefanie Kurtz, Antje Frenzel, Andrea Lucas-Hahn, Petra Hassel, Roswitha Becker, Maren Ziegler, Monika Nowak-Imialek, Brigitte Schlegelberger, Gudrun Göhring, Heiner Niemann, Björn Petersen

 

 

| Stem cells, regeneration & disease modelling

G2M splits mouse embryonic stem cells into naïve and formative pluripotency states
Kersti Jääger, Daniel Simpson, Maria Kalantzaki, Angela Salzano, Ian Chambers, Tamir Chandra

 

Regulation of Cyclin E by transcription factors of the naïve pluripotency network in mouse embryonic stem cells
Fabrice Gonnot, Diana Langer, Pierre-Yves Bourillot, Nathalie Doerflinger, Pierre Savatier

 

 

Dissecting mechanisms of human islet differentiation and maturation through epigenome profiling
Juan R. Alvarez-Dominguez, Julie Donaghey, Jennifer H. R. Kenty, Niloofar Rasouli, Aharon Helman, Jocelyn Charlton, Juerg R. Straubhaar, Alexander Meissner, Douglas A. Melton

 

Long noncoding RNAs sustain high expression of exogenous Oct4 by sponging miRNA during reprogramming
Qingran Kong, Xiaolei Zhang, Jiaming Zhang, Kailun Zheng, Heng Zhang, Xixiang Pei, Zhi Yin, Duancheng Wen, Zhonghua Liu

 

Control of glioblastoma differentiated-to-stem cell reprogramming by IRE1α/XBP1s signaling.
Dimitrios Doultsinos, Mari McMahon, Konstantinos Voutetakis, Joanna Obacz, Raphael Pineau, Florence Jouan, Pierre-Jean Le Reste, Akram Obiedat, Juhi Samal, John B Patterson, Quinping Zheng, Afshin Samali, Abhay Pandit, Boaz Tirosh, Aristotelis Chatziioannou, Eric Chevet, Tony Avril

 

Nanog regulates Pou3f1 expression and represses anterior fate at the exit from pluripotency
Antonio Barral, Isabel Rollan, Hector Sanchez-Iranzo, Wajid Jawaid, Claudio Badia-Careaga, Sergio Menchero, Manuel Gomez-Rodriguez, Carlos Torroja, Fatima Sanchez-Cabo, Berthold Göttgens, Miguel Manzanares, Julio Sainz de Aja

 

High fat diet induces a microbiota-dependent increase in stem cell activity in the Drosophila intestine
Jakob von Frieling, Muhammed Naeem Faisal, Femke Sporn, Roxana Pfefferkorn, Felix Sommer, Philip Rosenstiel, Thomas Roeder

 

A Comprehensive Molecular Portrait of Human Urine-derived Renal Progenitor Cells
Md Shaifur Rahman, Wasco Wruck, Lucas-Sebastian Spitzhorn, Martina Bohndorf, Soraia Martins, Fatima Asar, Audrey Ncube, Lars Erichsen, Nina Graffmann, James Adjaye

 

Pluripotent Stem Cells Can Be Isolated from Human Peripheral Nerves after in vitro BMP-2 Stimulation
Ren-Yi Sun, Michael H. Heggeness, Tanghong Jia, Sunaina Shrestha, Bradley Dart, Shang-You Yang

 

Redox potential defines functional states of adult hippocampal stem cells
Vijay S Adusumilli, Tara L Walker, Rupert W Overall, Gesa M Klatt, Salma A Zeidan, Tim J Fischer, Sara Zocher, Alex M Sykes, Susanne Reinhardt, Andreas Dahl, Dilyana G Kirova, Jörg Mansfeld, Annette E Rünker, Gerd Kempermann

 

Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5+ long-term hematopoietic stem cells
Gunsagar Singh Gulati, Monika Zukowska, Joseph Noh, Allison Zhang, Rahul Sinha, Benson George, Daniel Wesche, Irving L Weissman, Krzysztof Szade

 

Deciphering the protein dynamics and molecular determinants of iPSC-derived neurons
Suzy Varderidou-Minasian, Philipp Schätzle, Casper. C. Hoogenraad, R. Jeroen Pasterkamp, Maarten Altelaar

 

 

Single cell transcriptome analysis reveals markers of naïve and lineage-primed hematopoietic progenitors derived from human pluripotent stem cells
Antonella Fidanza, Nicola Romanò, Prakash Ramachandran, Sara Tamagno, Martha Lopez-Yrigoyen, Alice Helen Taylor, Jennifer Easterbrook, Beth Henderson, Richard Axton, Neil Cowan Henderson, Alexander Medvinsky, Katrin Ottersbach, Lesley Margaret Forrester LM

 

Use of human iPSCs and kidney organoids to develop a cysteamine/mTOR inhibition combination therapy to treat cystinosis
Jennifer A. Hollywood, Aneta Przepiorski, Patrick T. Harrison, Ernst J. Wolvetang, Alan J. Davidson, Teresa M. Holm

 

Identification of a basal stem cell subpopulation in the prostate via functional, lineage tracing and single-cell RNA-seq analyses
Xue Wang, Haibo Xu, Chaping Cheng, Zhongzhong Ji, Huifang Zhao, Yaru Sheng, Xiaoxia Li, Jinming Wang, Yu Shu, Yuman He, Liancheng Fan, Baijun Dong, Wei Xue, Chee Wai Chua, Dongdong Wu, Wei-Qiang Gao, Helen He Zhu

 

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes
Takeshi Katsuda, Juntaro Matsuzaki, Tomoko Yamaguchi, Yasuhiro Yamada, Kazunori Hosaka, Atsuko Takeuchi, Yoshimasa Saito, Takahiro Ochiya

 

Role of human induced pluripotent stem cell-derived spinal cord astrocytes in the functional maturation of motor neurons in a multielectrode array system
Arens Taga, Raha Dastgheyb, Christa Habela, Jessica Joseph, Jean-Philippe Richard, Sarah K. Gross, Giuseppe Lauria, Gabsang Lee, Norman Haughey, Nicholas J. Maragakis

 

The gene brain tumor constrains growth to ensure proper patterning during regeneration in Drosophila imaginal discs
Syeda Nayab Fatima Abidi, Rachel K. Smith-Bolton

 

Transpositional scaling and niche transitions restore organ size and shape during zebrafish fin regeneration
Scott Stewart, Gabriel A. Yette, Astra L. Henner, Heather K. Le Bleu, Joshua A. Braunstein, Jad W. Chehab, Michael J. Harms, Kryn Stankunas

 

Estrogen accelerates heart regeneration by promoting inflammatory responses in zebrafish
Shisan Xu, Fangjing Xie, Samane Fallah, Fatemeh Babaei, Lina Zhu, Kin Fung Wong, Yimin Liang, Rajkumar Ramalingam, Lei Sun, Xin Wang, Yun Wah Lam, Shuk Han Cheng

 

 

Inhibiting fibroblast aggregation in skin wounds unlocks developmental pathway to regeneration
Ashley Winn Seifert, Adam B Cook, Douglas Shaw

 

VEGF and FGF signaling during head regeneration in hydra
Anuprita Turwankar, Surendra Ghaskadbi

 

Electric-induced reversal of morphogenesis in Hydra regeneration
Erez Braun, Hillel Ori

 

Improvement of bone regeneration using fibrin biopolymer combined with differentiated stem cells
Camila Fernanda Zorzella Creste, Patrícia Rodrigues Orsi, Fernanda Cruz Landim-Alvarenga, Luis Antônio Justulin Jr, Marjorie de Assis Golim, Benedito Barraviera, Rui Seabra Ferreira Jr

 

 

Metabolic control of YAP via the acto-myosin system during liver regeneration
Kirstin Meyer, Hernan Morales-Navarrete, Sarah Seifert, Michaela Wilsch-Braeuninger, Uta Dahmen, Elly M. Tanaka, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial

 

Scar-less whole-body regeneration in the absence of a blastema requires cell division in the ctenophore Mnemiopsis leidyi
Julia Ramon Mateu, Mark Q. Martindale

 

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress
Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M. Wincovitch, Raman Sood, Fabio Candotti, Shawn M. Burgess

 

 

NCBP2-mediated apoptosis contributes to developmental defects of the schizophrenia-associated 3q29 deletion
Mayanglambam Dhruba Singh, Matthew Jensen, Micaela Lasser, Emily Huber, Tanzeen Yusuff, Lucilla Pizzo, Brian Lifschutz, Inshya Desai, Alexis Kubina, Sneha Yennawar, Sydney Kim, Janani Iyer, Diego E. Rincon-Limas, Laura Anne Lowery, Santhosh Girirajan

 

Huntingtin confers fitness but is not embryonically essential in zebrafish development
Harwin Sidik, Christy J. Ang, Mahmoud A. Pouladi

 

Disruption of genes associated with Charcot-Marie-Tooth type 2 lead to common behavioural, cellular and molecular defects in Caenorhabditis elegans
Ming S. Soh, Xinran Cheng, Jie Liu, Brent Neumann

 

Mutant MFN2/fzo-1 selectively removes mitochondrial DNA heteroplasmy in Caenorhabditis elegans and in Charcot-Marie-Tooth patients
Lana Meshnik, Dan Bar-Yaacov, Dana Kasztan, Tal Cohen, Mor Kishner, Itay Valenci, Sara Dadon, Christopher J. Klein, Jeffery M. Vance, Yoram Nevo, Stephan Zuchner, Dan Mishmar, Anat Ben-Zvi

 

Quantitative proteomic alterations of human iPSC-based neuronal development indicate early onset of Rett syndrome
Suzy Varderidou-Minasian, Lisa Hinz, Dominique Hagemans, Danielle Posthuma, Maarten Altelaar, Vivi M. Heine

 

Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome
Giovanni A. Carosso, Leandros Boukas, Jonathan J. Augustin, Ha Nam Nguyen, Briana L. Winer, Gabrielle H. Cannon, Johanna D. Robertson, Li Zhang, Kasper D. Hansen, Loyal A. Goff, Hans T. Bjornsson

 

Post-ictal neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy
Kunal Gupta, Eric Schnell

 

Amelioration of muscular dystrophy phenotype in mdx mice by inhibition of Flt1
Mayank Verma, Yuko Shimizu-Motohashi, Yoko Asakura, James Ennen, Jennifer Bosco, Zhiwei Zou, Guo-Hua Fong, Serene Josiah, Dennis Keefe, Atsushi Asakura

 

Impaired KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathogenesis
Lucie I. Pisella, Jean-Luc Gaiarsa, Diabé Diabira, Jinwei Zhang, Ilgam Khalilov, JingJing Duan, Kristopher T. Kahle, Igor Medina

 

Stasimon contributes to the loss of sensory synapses and motor neuron death in a mouse model of spinal muscular atrophy
Christian M Simon, Meaghan Van Alstyne, Francesco Lotti, Elena Bianchetti, Sarah Tisdale, George Z Mentis, Livio Pellizzoni

 

Atrx deletion in neurons leads to sexually-dimorphic dysregulation of miR-137 and spatial learning and memory deficits
Renee J. Tamming, Vanessa Dumeaux, Luana Langlois, Jacob Ellegood, Lily R. Qiu, Yan Jiang, Jason P. Lerch, Nathalie G. Bérubé

 

Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome
Anish K. Simhal, Yi Zuo, Marc M. Perez, Daniel V. Madison, Guillermo Sapiro, Kristina D. Micheva

 

 

| Plant development

 

ELIMÄKI locus is required for mechanosensing and proprioception in birch trees
Juan Alonso-Serra, Xueping Shi, Alexis Peaucelle, Pasi Rastas, Matthieu Bourdon, Juha Immanen, Junko Takahashi, Hanna Koivula, Gugan Eswaran, Sampo Muranen, Hanna Help-Rinta-Rahko, Olli-Pekka Smolander, Chang Su, Omid Safronov, Lorenz Gerber, Jarkko Salojärvi, Risto Hagqvist, Ari-Pekka Mähonen, Kaisa Nieminen, Ykä Helariutta

 

 

The power of model-to-crop translation illustrated by reducing seed loss from pod shatter in oilseed rape
Pauline Stephenson, Nicola Stacey, Marie Brüser, Nick Pullen, Muhammad Ilyas, Carmel O’Neill, Rachel Wells, Lars Østergaard

 

 

A Plant-Specific Polarity Module Establishes Cell Fate Asymmetry in the Arabidopsis Stomatal Lineage
Matthew H. Rowe, Juan Dong, Annika K. Weimer, Dominique C. Bergmann

 

SUPPRESSOR OF MAX2 1-LIKE 5 promotes secondary phloem formation during radial stem growth
Eva-Sophie Wallner, Virginie Jouannet, Thomas Greb

 

Spatiotemporal restriction of FUSCA3 expression by class I BPC promotes ovule development and coordinates embryo and endosperm growth
Jian Wu, Rosanna Petrella, Sebastian Dowhanik, Veronica Gregis, Sonia Gazzarrini

 

The receptor-like kinases BAM1 and BAM2 promote the cell-to-cell movement of miRNA in the root stele to regulate xylem patterning
Pengfei Fan, Hua Wang, Hao Xue, Tabata Rosas-Diaz, Weihua Tang, Heng Zhang, Lin Xu, Rosa Lozano-Duran

 

CrRLK1L receptor-like kinases HERCULES RECEPTOR KINASE 1 and ANJEA are female determinants of pollen tube reception
Sergio Galindo-Trigo, Noel Blanco-Touriñán, Thomas A. DeFalco, Eloise S. Wells, Julie E Gray, Cyril Zipfel, Lisa M Smith

 

Redistribution of NORTIA in response to pollen tube arrival facilitates fertilization in Arabidopsis thaliana
Jing Yuan, Yan Ju, Daniel S Jones, Weiwei Zhang, Noel Lucca, Christopher J Staiger, Sharon A Kessler

 

Identification of a role for an E6-like 1 gene in early pollen-stigma interactions in Arabidopsis thaliana
Jennifer Doucet, Christina Truong, Elizabeth Frank-Webb, Hyun Kyung Lee, Anna Daneva, Zhen Gao, Moritz Nowack, Daphne Goring

 

 

A microtubule-mediated mechanical feedback controls leaf blade development in three dimensions
Feng Zhao, Fei Du, Hadrien Oliveri, Lüwen Zhou, Olivier Ali, Wenqian Chen, Shiliang Feng, Qingqing Wang, Shouqin Lü, Mian Long, René Schneider, Arun Sampathkumar, Christophe Godin, Jan Traas, Yuling Jiao

 

Mechanical constraints influence microtubule orientation in plant cells
S Bachmann, R Froese, EN Cytrynbaum

 

The HAC1 Histone Acetyltransferase Promotes Leaf Senescence via Regulation of ERF022
Will E. Hinckley, Keykhosrow Keymanesh, Jaime A. Cordova, Judy A. Brusslan

 

Mapping and dynamics of regulatory DNA in maturing seeds
Alessandra M Sullivan, Andrej A Arsovski, Agnieszka Thompson, Richard Sandstrom, Robert E Thurman, Shane Neph, Audra K Johnson, Shawn T Sullivan, Peter J Sabo, Fidencio V Neri III, Molly Weaver, Morgan Diegel, Jennifer L Nemhauser, John A Stamatoyannopoulos, Kerry L Bubb, Christine Queitsch

 

Paternally-acting canonical RNA-directed DNA methylation pathway genes sensitize Arabidopsis endosperm to paternal genome dosage
P. R. V. Satyaki, Mary Gehring

 

Molecular framework for TIR1/AFB-Aux/IAA-dependent auxin sensing controlling adventitious rooting in Arabidopsis
Abdellah Lakehal, Salma Chaabouni, Emilie Cavel, Rozenn Le Hir, Alok Ranjan, Zahra Raneshan, Ondřej Novák, Daniel I. Păcurar, Irene Perrone, François Jobert, Laurent Gutierrez, Laszlo Bakò, Catherine Bellini

 

A role for the auxin precursor anthranilic acid in root gravitropism via regulation of PIN-FORMED protein polarity and relocalization in Arabidopsis
Siamsa M. Doyle, Adeline Rigal, Peter Grones, Michal Karady, Deepak K. Barange, Mateusz Majda, Barbora Pařízková, Michael Karampelias, Marta Zwiewka, Aleš Pěnčik, Fredrik Almqvist, Karin Ljung, Ondřej Novák, Stéphanie Robert

 

 

Xyloglucan homeostasis and microtubule dynamics synergistically maintain meristem geometry and robustness of phyllotaxis in Arabidopsis
Feng Zhao, Wenqian Chen, Julien Sechet, Marjolaine Martin, Simone Bovio, Claire Lionnet, Yuchen Long, Virginie Battu, Grégory Mouille, Françoise Monéger, Jan Traas

 

WRKY1 mediates transcriptional crosstalk between light and nitrogen signaling pathways in Arabidopsis thaliana
Sachin Heerah, Manpreet Katari, Rebecca Penjor, Gloria Coruzzi, Amy Marshall-Colon

 

A novel mutant allele uncouples brassinosteroid-dependent and independent functions of BRI1
Eleonore Holzwart, Nina Glöckner, Herman Höfte, Klaus Harter, Sebastian Wolf

 

Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase
Laurence Cromer, Sylvie Jolivet, Dipesh Kumar Singh, Floriane Berthier, Nancy De Winne, Geert De Jaeger, Shinichiro Komaki, Maria Ada Prusicki, Arp Schnittger, Raphael Guérois, Raphael Mercier

 

The Maize LINC KASH AtSINE-like2 (MLKS2) gene encodes an ARM domain protein that tethers the nucleus to F-actin and is required for normal development and meiotic chromosome segregation
Hardeep K Gumber, Joseph F McKenna, Andrea F Tolmie, Alexis M Jalovec, Andre C Kartick, Katja Graumann, Hank W Bass

 

Reconstructing the transcriptional ontogeny of maize and sorghum supports an inverse hourglass model of inflorescence development
Samuel Leiboff, Sarah Hake

 

The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons
Rita A. Batista, Jordi Moreno-Romero, Joram van Boven, Yichun Qiu, Juan Santos-González, Duarte D. Figueiredo, Claudia Köhler

 

Reduced chromatin accessibility underlies gene expression differences in homologous chromosome arms of hexaploid wheat and diploid Aegilops tauschii
Fu-Hao Lu, Neil McKenzie, Laura-Jayne Gardiner, Ming-Cheng Luo, Anthony Hall, Michael W Bevan

 

GNI-A1 mediates trade-off between grain number and grain weight in tetraploid wheat
Guy Golan, Idan Ayalon, Aviad Perry, Gil Zimran, Toluwanimi Ade-Ajayi, Assaf Mosquna, Assaf Distelfeld, Zvi Peleg

 

Identification of a dominant chlorosis phenotype through a forward screen of the Triticum turgidum cv. Kronos TILLING population
Sophie A. Harrington, Nicolas Cobo, Miroslava Karafiatova, Jaroslav Dolezel, Philippa Borrill, Cristobal Uauy

 

Extension of the in vivo haploid induction system from maize to wheat
Chenxu Liu, Yu Zhong, Xiaolong Qi, Ming Chen, Zongkai Liu, Chen Chen, Xiaolong Tian, Jinlong Li, Yanyan Jiao, Dong wang, Yuwen Wang, Mengran Li, Mingming Xin, Wenxin Liu, Weiwei Jin, Shaojiang Chen

 

A Cys2/His2 zinc finger protein acts as a repressor of gibberellins biosynthesis by regulating SD1/OsGA20ox2 in rice (Oryza sativa L.)
Min Duan, Xiao-Juan Ke, Hong-Xia Lan, Xi Yuan, Peng Huang, En-Shun Xu, Xiu-Ying Gao, Ru-Qin Wang, Hai-Juan Tang, Hong-Sheng Zhang, Ji Huang

 

Impact of within-tree organ distances on floral induction and fruit growth in apple tree: implication of carbon and gibberellin organ contents
Farés Belhassine, Sébastien Martinez, Sylvie Bluy, Damien Fumey, Jean-Jacques Kelner, Evelyne Costes, Benoît Pallas

 

 

Evo-devo & evo

 

 

Pigeon foot feathering reveals conserved limb identity networks
Elena F. Boer, Hannah F. Van Hollebeke, Sungdae Park, Carlos R. Infante, Douglas B. Menke, Michael D. Shapiro

 

Frequent Non-random Shifts in the Temporal Sequence of Developmental Landmark Events during Teleost Evolutionary Diversification
Fumihiro Ito, Tomotaka Matsumoto, Tatsumi Hirata

 

Ancestral role of Fat-like cadherins in planar cell polarity
Maria Brooun, Alexander Klimovich, Mikhail Bashkurov, Bret J. Pearson, Robert E. Steele, Helen McNeill

 

 

Studying early embryogenesis in the flatworm Maritigrella crozieri indicates a unique modification of the spiral cleavage program in polyclad flatworms
Johannes Girstmair, Maximilian J. Telford

 

Cell proliferation controls body size growth, tentacle morphogenesis, and regeneration in hydrozoan jellyfish Cladonema pacificum
Sosuke Fujita, Erina Kuranaga, Yuichiro Nakajima

 

Dorsoventral dissociation of Hox gene expression underpins the diversification of molluscs
Pin Huan, Qian Wang, Sujian Tan, Baozhong Liu

 

Active mode of excretion across digestive tissues predates the origin of excretory organs
Carmen Andrikou, Daniel Thiel, Juan A. Ruiz-Santiesteban, Andreas Hejnol

 

Fog signaling has diverse roles in epithelial morphogenesis in insects
Nadine Frey, Matthew A. Benton, Rodrigo Nunes da Fonseca, Cornelia von Levetzow, Dominik Stappert, Muhammad Salim Hakeemi, Kai H. Conrads, Matthias Pechmann, Kristen A. Panfilio, Jeremy A. Lynch, Siegfried Roth

 

Comparative transcriptomics analyses across species, organs and developmental stages reveal functionally constrained lncRNAs
Fabrice Darbellay, Anamaria Necsulea

 

Evolution of simple multicellular life cycles in dynamic environments
Yuriy Pichugin, Hye Jin Park, Arne Traulsen

 

Meta-population structure and the evolutionary transition to multicellularity
Caroline J. Rose, Katrin Hammerschmidt, Paul B. Rainey

 

Temperature preference does not evolve in sticklebacks despite multigenerational exposure to elevated temperatures
Natalie Pilakouta, Shaun S. Killen, Bjarni K. Kristjánsson, Skúli Skúlason, Jan Lindström, Neil B. Metcalfe, Kevin J. Parsons

 

Mapping of multiple complementary sex determination loci in a parasitoid wasp
Cyril Matthey-Doret, Casper J. van der Kooi, Daniel L. Jeffries, Jens Bast, Alice B. Dennis, Christoph Vorburger, Tanja Schwander

 

Two Y chromosome-encoded genes determine sex in kiwifruit
Takashi Akagi, Sarah M. Pilkington, Erika Varkonyi-Gasic, Isabelle M. Henry, Shigeo S. Sugano, Minori Sonoda, Alana Firl, Mark A. McNeilage, Mikaela J. Douglas, Tianchi Wang, Ria Rebstock, Charlotte Voogd, Paul Datson, Andrew C. Allan, Kenji Beppu, Ikuo Kataoka, Ryutaro Tao

 

Evolution of Yin and Yang isoforms of a chromatin remodeling subunit results in the creation of two genes
Wen Xu, Lijiang Long, Yuehui Zhao, Lewis Stevens, Ronald E. Ellis, Patrick T. McGrath

 

Within-population genome size variation is mediated by multiple genomic elements that segregate independently during meiosis
Claus-Peter Stelzer, Maria Pichler, Peter Stadler, Anita Hatheuer, Simone Riss

 

The ebb and flow of heteroplasmy during intra-species hybridization in Caenorhabditis briggsae
Shadi Adineh, Joseph Ross

 

Transcriptome Surveys in Silverfish Suggest a Multistep Origin of the Insect Odorant Receptor Gene Family
Michael Thoma, Christine Missbach, Melissa D. Jordan, Ewald Grosse-Wilde, Richard D. Newcomb, Bill S. Hansson

 

Dynamic chromosome rearrangements of the white-spotted bamboo shark shed light on cartilaginous fish diversification mechanisms
Yaolei Zhang, Haoyang Gao, Hanbo Li, Jiao Guo, Meiniang Wang, Qiwu Xu, Jiahao Wang, Meiqi Lv, Xinyu Guo, Qun Liu, Likun Wei, Han Ren, Yang Xi, Yang Guo, Qian Zhao, Shanshan Pan, Chuxin Liu, Liping Sang, Xiaoyan Ding, Chen Wang, Haitao Xiang, Yue Song, Yujie Liu, Shanshan Liu, Yuan Jiang, Changwei Shao, Jiahai Shi, Shiping Liu, Jamal S. M. Sabir, Mumdooh J. Sabir, Muhummadh Khan, Nahid H. Hajrah, Simon Ming-Yuen Lee, Xun Xu, Huanming Yang, Jian Wang, Guangyi Fan, Naibo Yang, Xin Liu

 

Cell biology

 

Spherical Spindle Shape Promotes Perpendicular Cortical Orientation by Preventing Isometric Cortical Pulling on both Spindle Poles during C. elegans Female Meiosis
Elizabeth Vargas, Karen P. McNally, Daniel B. Cortes, Michelle T. Panzica, Amy Shaub-Maddox, Francis J. McNally

 

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes
Rupali Ugrankar, Jade Bowerman, Hanaa Hariri, Mintu Chandra, Kevin Chen, Marie-France Bossanyi, Sanchari Datta, Sean Rogers, Kaitlyn M. Eckert, Gonçalo Vale, Alexia Victoria, Joseph Fresquez, Jeffrey G. McDonald, Steve Jean, Brett M. Collins, W. Mike Henne

 

RhoA mediates epithelial cell shape changes via mechanosensitive endocytosis
Kate E. Cavanaugh, Michael F. Staddon, Ed Munro, Shiladitya Banerjee, Margaret L. Gardel

 

Basement membrane regulates fibronectin organization using sliding focal adhesions driven by a contractile winch
Jiaoyang Lu, Andrew D. Doyle, Yoshinari Shinsato, Shaohe Wang, Molly A. Bodendorfer, Minhua Zheng, Kenneth M. Yamada

 

Cell-projection pumping: A hydrodynamic cell-stiffness dependent mechanism for cytoplasmic transfer between mammalian cells
Hans Zoellner, Navid Paknejad, James Cornwell, Belal Chami, Yevgeniy Romin, Vitaly Boykov, Sho Fujisawa, Elizabeth Kelly, Garry W. Lynch, Glynn Rogers, Katia Manova, Malcolm A.S. Moore

 

WASP restricts active Rac to maintain cells’ front-rear polarisation
Clelia Amato, Peter Thomason, Andrew Davidson, Karthic Swaminathan, Shehab Ismail, Laura Machesky, Robert Insall

 

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE Regulatory Complex-binding
Matthias Schaks, Hermann Döring, Frieda Kage, Anika Steffen, Thomas Klünemann, Wulf Blankenfeldt, Theresia Stradal, Klemens Rottner

 

Snail induces epithelial cell extrusion through transcriptional control of RhoA contractile signaling and cell matrix adhesion
Kenneth Wee, Suroor Zadeh, Suzie Verma, Roger J. Daly, Alpha S. Yap, Melissa J. Davis, Srikanth Budnar

 

EMT-induced cell mechanical changes enhance mitotic rounding strength
Kamran Hosseini, Anna Taubenberger, Carsten Werner, Elisabeth Fischer-Friedrich

 

 

Mitotic exit is controlled during anaphase by an Aurora B-Cyclin B1/Cdk1 crosstalk
Olga Afonso, Liam P. Cheeseman, Luísa T. Ferreira, Eurico Morais-de-Sá, Helder Maiato

 

Direct transfer of a kinetochore between microtubules is fundamental to error correction mechanism
Harinath Doodhi, Taciana Kasciukovic, Marek Gierlinski, Shuyu Li, Lesley Clayton, Tomoyuki U. Tanaka

 

Re-configuration of Chromatin Structure During the Mitosis-G1 Phase Transition
Haoyue Zhang, Daniel J. Emerson, Thomas G. Gilgenast, Katelyn R. Titus, Yemin Lan, Peng Huang, Di Zhang, Hongxin Wang, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Jennifer E Phillips-Cremins, Gerd A. Blobel

 

Microtubule glycylation promotes basal body attachment to the cell cortex
Anthony D. Junker, Adam W. J. Soh, Eileen T. O’Toole, Janet B. Meehl, Mayukh Guha, Mark Winey, Jerry E. Honts, Jacek Gaertig, Chad G. Pearson

 

RanGTP regulates cilium formation and ciliary trafficking of a kinesin-II subunit independent of its nuclear functions
Shengping Huang, Prachee Avasthi

 

 

Modelling

Isotropic expansion of external environment induces tissue elongation and collective cell alignment
H. Koyama, T. Fujimori

 

Modularity, criticality, and evolvability of a developmental gene regulatory network
Berta Verd, Nicholas AM Monk, Johannes Jaeger

 

Theoretical modeling on CRISPR-coded cell lineages: efficient encoding and optimal reconstruction
Ken Sugino, Jorge Garcia Marques, Isabel Espinosa Medina, Tzumin Lee

 

Robust Reconstruction of CRISPR and Tumor Lineage Using Depth Metrics
Ken Sugino, Tzumin Lee

 

 

Estimation of cell lineage trees by maximum-likelihood phylogenetics
Jean Feng, William S DeWitt III, Aaron McKenna, Noah Simon, Amy Willis, Frederick A Matsen IV

 

Modeling tumorspheres reveals cancer stem cell niche building and plasticity
L. Benítez, L. Barberis, C. A. Condat

 

Morphogenesis Software based on Epigenetic Code Concept
N. Bessonov, O.Butuzova, A.Minarsky, R. Penner, C. Soule, A. Tosenberger, N. Morozova

 

Seeding hESCs to achieve optimal colony clonality
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova, Sanja Bojic, Alex Laude, Majlina Lako, Nicholas G Parker, Anvar Shukurov

 

Mechanical constraints influence microtubule orientation in plant cells
Sven Bachmann, Richard Froese, Eric N Cytrynbaum

 

The role of network topology, growth laws and mechanics in the dynamics of cell assemblies
Alexander Erlich, Gareth W. Jones, Françoise Tisseur, Derek E. Moulton, Alain Goriely

 

An Analytical Theory of Cellular Growth
Hugo Dourado, Martin J. Lercher

 

An individual-based mechanical model of cell movement in heterogeneous tissues and its coarse-grained approximation
R. J. Murphy, P. R. Buenzli, R. E. Baker, M. J. Simpson

 

Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: insights from an agent-based model
Daniel Ward, Alexander G. Fletcher, Martin Homer, Lucia Marucci

 

The FLAME-accelerated Signalling Tool (FaST): A tool for facile parallelisation of flexible agent-based models of cell signalling
Gavin Fullstone, Cristiano Guttà, Amatus Beyer, Markus Rehm

 

Modeling enamel matrix secretion in mammalian teeth
Teemu J. Häkkinen, S. Susanna Sova, Ian J. Corfe, Leo Tjäderhane, Antti Hannukainen, Jukka Jernvall

 

Cell fate determination by Lamarckian molecule-inheritance and chance
Frank J. Bruggeman, Jaap Schouten, Daan H. de Groot, Robert Planqué

 

 

 

Tools & resources

 

 

Identification of neuronal lineages in the Drosophila peripheral nervous system with a novel multi-spectral lineage tracing system
Macy W. Veling, Ye Li, Mike T. Veling, Christopher Litts, Nigel Michki, Hao Liu, Dawen Cai, Bing Ye

 

Differential Expression Gene Explorer (DrEdGE): A tool for generating interactive online data visualizations for exploration of quantitative transcript abundance datasets
Sophia C. Tintori, Patrick Golden, Bob Goldstein

 

DNA barcoding reveals that injected transgenes are predominantly processed by homologous recombination in mouse zygote
Alexander Smirnov, Anastasia Yunusova, Alexey Korablev, Irina Serova, Veniamin Fishman, Nariman Battulin

 

Enabling large-scale genome editing by reducing DNA nicking
Cory J. Smith, Oscar Castanon, Khaled Said, Verena Volf, Parastoo Khoshakhlagh, Amanda Hornick, Raphael Ferreira, Chun-Ting Wu, Marc Güell, Shilpa Garg, Hannu Myllykallio, George M. Church

 

Heat-triggered remote control of CRISPR-dCas9 for tunable transcriptional modulation
Lena Gamboa, Erick V. Phung, Haoxin Li, Jared P. Meyers, Gabriel A. Kwong

 

Suppression of unwanted CRISPR/Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs
John C. Rose, Nicholas A. Popp, Christopher D. Richardson, Jason J. Stephany, Julie Mathieu, Cindy T. Wei, Jacob E. Corn, Dustin J. Maly, Douglas M. Fowler

 

Multiplexed and Inducible Gene Modulation in Human Pluripotent Stem Cells by CRISPR Interference and Activation
Dane Z. Hazelbaker, Amanda Beccard, Patrizia Mazzucato, Gabriella Angelini, Angelica Messana, Daisy Lam, Kevin Eggan, Lindy E. Barrett

 

Fast and cloning-free CRISPR/Cas9-mediated genomic editing in mammalian cells
Paul T. Manna, Luther J. Davis, Margaret S. Robinson

 

 

A simple and efficient CRISPR technique for protein tagging
Fanning Zeng, Valerie Beck, Sven Schuierer, Isabelle Garnier, Carole Manneville, Claudia Agarinis, Lapo Morelli, Lisa Quinn, Judith Knehr, Guglielmo Roma, Frederic Bassilana, Mark Nash

 

A Pandas complex adapted for piRNA-guided transposon silencing
Kang Zhao, Sha Cheng, Na Miao, Ping Xu, Xiaohua Lu, Ming Wang, Yuhan Zhang, Xun Yuan, Weiwei Liu, Xin Lu, Xuan Ouyang, Peng Zhou, Jiaqi Gu, Yiqun Zhang, Ding Qiu, Shan Wang, Zhaohui Jin, Youzhong Wan, Jinbiao Ma, Ying Huang, Yang Yu

 

ORF Capture-Seq: a versatile method for targeted identification of full-length isoforms
Gloria M. Sheynkman, Katharine S. Tuttle, Elizabeth Tseng, Jason G. Underwood, Liang Yu, Da Dong, Melissa L. Smith, Robert Sebra, Tong Hao, Michael A. Calderwood, David E. Hill, Marc Vidal

 

The full-length transcriptome of C. elegans using direct RNA sequencing
Nathan P. Roach, Norah Sadowski, Amelia F. Alessi, Winston Timp, James Taylor, John K. Kim

 

Decoding neuronal diversity by single-cell Convert-seq
Joachim Luginbühl, Tsukasa Kouno, Rei Nakano, Thomas E Chater, Divya M Sivaraman, Mami Kishima, Filip Roudnicky, Piero Carninci, Charles Plessy, Jay W Shin

 

Optimal marker gene selection for cell type discrimination in single cell analyses
Bianca Dumitrascu, Soledad Villar, Dustin G. Mixon, Barbara E. Engelhardt

 

dropClust2: An R package for resource efficient analysis of large scale single cell RNA-Seq data
Debajyoti Sinha, Pradyumn Sinha, Ritwik Saha, Sanghamitra Bandyopadhyay, Debarka Sengupta

 

 

Congruence of location-specific transcriptional programs in intestinal organoids during long-term culture
Bart van der Hee, Ole Madsen, Hauke Smidt, Jerry M Wells

 

A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells
Charlotte R. Feddersen, Lexy S. Wadsworth, Eliot Y. Zhu, Hayley R. Vaughn, Andrew P. Voigt, Jesse D. Riordan, Adam J. Dupuy

 

High-throughput, image-based flow cytometry and clustering method for phenotyping heterogeneous cell populations
Robert Peuß, Andrew C. Box, Alice Accorsi, Christopher Wood, Alejandro Sánchez Alvarado, Nicolas Rohner

 

A reference map of the human protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Cote, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, Vincent Tropepe, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

 

A genetically-encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling
David L. Prole, Colin W. Taylor

 

tagPAINT: Stoichiometric and covalent labelling of protein tags for multiplexed and quantitative DNA-PAINT imaging
Daniel J. Nieves, Geva Hilzenrat, Jason Tran, Zhengmin Yang, Hugh H. MacRae, Matthew A. B. Baker, J Justin Gooding, Katharina Gaus

 

Imaging chromatin interactions at sub-kilobase resolution Via Tn5-FISH
Xu Zhang, Jing Niu, Guipeng Li, Qionghai Dai, Dayong Jin, Juntao Gao, Michael Q. Zhang

 

An enhanced molecular tension sensor based on bioluminescence resonance energy transfer (BRET)
Eric J. Aird, Kassidy J. Tompkins, Wendy R. Gordon

 

 

Quantitative measurements of chromatin modification dynamics during zygotic genome activation
Yuko Sato, Lennart Hilbert, Haruka Oda, Yinan Wan, John M. Heddleston, Teng-Leong Chew, Vasily Zaburdaev, Philipp Keller, Timothee Lionnet, Nadine Vastenhouw, Hiroshi Kimura

 

 

Light-sheet microscopy with isotropic, sub-micron resolution and solvent-independent large-scale imaging
Tonmoy Chakraborty, Meghan Driscoll, Malea Murphy, Philippe Roudot, Bo-Jui Chang, Saumya Vora, Wen Mai Wong, Cara Nielson, Hua Zhang, Vladimir Zhemkov, Chitkale Hiremath, Estanislao Daniel De La Cruz, Ilya Bezprozvanny, Hu Zhao, Raju Tomer, Rainer Heintzmann, Julian Meeks, Denise Marciano, Sean Morrison, Gaudenz Danuser, Kevin M. Dean, Reto Fiolka

 

Rapid 3D enhanced resolution microscopy reveals the dynamics of cortical dendritic spinules
CR Zaccard, K Myczek, MD Martin-de-Saavedra, P Penzes

 

3D Multicolor Nanoscopy at 10,000 Cells a Day
Andrew E S Barentine, Yu Lin, Miao Liu, Phylicia Kidd, Leonhard Balduf, Michael R Grace, Siyuan Wang, Joerg Bewersdorf, David Baddeley

 

EpiGraph: an open-source platform to quantify epithelial organization
Pablo Vicente-Munuera, Pedro Gómez-Gálvez, Robert J. Tetley, Cristina Forja, Antonio Tagua, Marta Letrán, Melda Tozluoglu, Yanlan Mao, Luis M. Escudero

 

DLITE uses cell-cell interface movement to better infer cell-cell tensions
Ritvik Vasan, Mary M Maleckar, Charles David Williams, Padmini Rangamani

 

Research practice & education

Co-reviewing and ghostwriting by early career researchers in the peer review of manuscripts
Gary S. McDowell, John Knutsen, June Graham, Sarah K. Oelker, Rebeccah S. Lijek

 

Gender and international diversity improves equity in peer review
Dakota Murray, Kyle Siler, Vincent Larivière, Wei Mun Chan, Andrew M. Collings, Jennifer Raymond, Cassidy R. Sugimoto

 

The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences
Rachel Drysdale, Charles E Cook, Robert Petryszak, Vivienne Baillie Gerritsen, Mary Barlow, Elisabeth Gasteiger, Franziska Gruhl, Juergen Haas, Jeremy Lanfear, Rodrigo Lopez, Nicole Redaschi, Heinz Stockinger, Daniel Teixeira, Aravind Venkatesan, ELIXIR Core Data Resource Forum, Niklas Blomberg, Christine Durinx, Jo McEntyre

 

Moving beyond P values: Everyday data analysis with estimation plots
Joses Ho, Tayfun Tumkaya, Sameer Aryal, Hyungwon Choi, Adam Claridge-Chang

 

Tracking the popularity and outcomes of all bioRxiv preprints
Richard J. Abdill, Ran Blekhman

 

Abandoning statistical significance is both sensible and practical
Valentin Amrhein, Andrew Gelman, Sander Greenland, Blakeley B McShane

 

Use of the Journal Impact Factor in academic review, promotion, and tenure evaluations
Erin C. McKiernan​, Lesley A. Schimanski, Carol Muñoz Nieves, Lisa Matthias, Meredith T. Niles, Juan Pablo Alperin

 

Why not…

Morphogenesis and dynamics of slime molds in various environments
Fernando Patino-Ramirez, Aurèle Boussard, Chloé Arson, Audrey Dussutour

 

Not dead yet: Diatom resting spores can survive in nature for several millennia
Anushree Sanyal, Josefine Larsson, Falkje van Wirdum, Thomas Andrén, Matthias Moros, Mikael Lönn, Elinor Andrén

 

Left-handedness is associated with greater fighting success in humans
Thomas Richardson, Tucker Gilman

 

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