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About: Hannah Long

In my research I investigate how gene expression is regulated during development, and how this can go awry in human disease. I have focused on congenital craniofacial abnormalities, and understanding how non-coding genetic mutations can drive these disorders. I did my undergraduate studies at the University of Cambridge in the Natural Sciences, and was awarded her DPhil at the University of Oxford Biochemistry Department in 2014 as a student in the Wellcome Trust Graduate Programme in Chromosome and Developmental Biology. During my PhD, I worked with Professors Rob Klose and Roger Patient to uncover conservation of non-methylated islands across vertebrate species and interrogate DNA sequence features that contribute to DNA methylation status. In my post-doctoral work, as a Sir Henry Wellcome post-doctoral research fellow in the laboratory of Professor Joanna Wysocka at Stanford University, I have investigated mechanisms of developmental gene regulation, with a focus on long-range enhancer function in craniofacial development, evolution and disease.

Posts by Hannah Long:

A facial birth defect is caused by perturbation of extreme long-range enhancers

Posted by on January 25th, 2021

By Hannah Long  From the almost identical faces of monozygotic twins, we can appreciate that facial appearance is encoded for the most-part in the DNA of our genomes. Therefore, changes to this DNA sequence can contribute to the variation in facial appearance seen between humans, and at the more extreme end of the spectrum can[…]