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Displaying posts in the category: Research

YEN 2016 review

Posted by , on 26 June 2016

My informal review of YEN this year is by necessity a bit rushed but, for what it is, here it is. Most reviews are very short and pithy/jealous and only ...

Model Organism Database funding is in trouble: Let your voice be heard

Posted by , on 23 June 2016

  Model Organisms such as yeast, worm, fly, fish, rat, and mouse are key drivers of biological research, providing manipulable and cost-effective experimental systems that continuously yield fundamental insights into ...

Reproducibility: a pathological perspective

Posted by , on 20 June 2016

” the ability to reproduce experimental findings remains essential for the forward movement of science and the application of laboratory findings to the clinic”   This is an extract from ...

Sweetening with a pinch of salt: maximized Cas9 efficiency in zebrafish

Posted by , on 14 June 2016

  Alexa Burger, Mosimann lab, Institute of Molecular Life Sciences, University of Zürich, Switzerland. When I first heard about the “new” genome editing method in early 2013 called CRISPR-Cas9, I ...

Post-doc in Paris: Studying Stem Cell Genome Stability using Drosophila Intestinal Stem Cells (Biologists or Bioinformaticians)

Posted by , on 10 June 2016

Maintaining genome integrity of adult stem cells is important to prevent cancer initiation and stem cell functional decline during aging. Our recent work (Siudeja, Cell Stem Cell, 2015) has demonstrated ...

3D mini-brain sheds light on Zika Virus in the brain

Posted by , on 10 June 2016

The Zika virus is making headlines as a major world health crisis linked to a host of neurological conditions. In the cases of microcephaly and Guillain-Barre, the evidence that Zika Virus ...

Improving the design of animal experiments: Introducing the Experimental Design Assistant (EDA)

Posted by , on 7 June 2016

This post was originally published as a Newsletter article from ShARM (Shared Ageing Research Models) Scientists using animals in research have a responsibility to ensure that the studies are appropriately designed, conducted, ...

Cellular conversations

Posted by , on 7 June 2016

We know that cells are the building blocks of our bodies. But they are not like inert wooden blocks. They are complicated tiny machines that communicate with each other to ...

In Development this week (Vol. 143, Issue 11)

Posted by , on 31 May 2016

Here are the highlights from the current issue of Development:   A new paradigm for Wnt/β-catenin signalling The Wnt/β-catenin signalling pathway is a key pathway involved in a myriad of ...

Geometrical models of tissue as tools for uncovering rules underlying tissue organization

Posted by , on 27 May 2016

A major challenge in cell and developmental biology is to understand the mechanisms whereby cells interact with each other to form the variety of complex tissue forms present in organisms. ...

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