December 12
Posted by the Node, on 12 December 2012
Today’s recommended paper is:
A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration
Gregory F. Weber, Maureen A. Bjerke and Douglas W. DeSimone (December 2011)
Developmental Cell 22 (1), 104-115
Submitted by Katherine Brown
“This beautiful paper uses cadherin-coated magnetic beads applied to single Xenopus gastrula cells in culture to demonstrate that tension polarises the cell and determines the direction of migration, and to investigate the mechanosensory pathway involved. The work exemplifies our increasing appreciation of the role that physical forces have in determining cell and tissue behaviour during development.”
From December 1 to 24 we are featuring Node readers’ favourite papers of the past year. Click the calendar in the side bar each day to see a new paper. To see all papers submitted so far, see the calendar archive.
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