4-year PhD position in Stem cell biology/computational modelling, University of Sheffield
Posted by Anestis Tsakiridis, on 9 October 2023
Location: University of Sheffield
Closing Date: 7 January 2024
The groups of Alex Fletcher (https://www.sheffield.ac.uk/maths/people/academic/alexander-fletcher) and Anestis Tsakiridis (https://www.tsakiridislab.com/) are offering a PhD project combining stem cell/developmental biology and computational modelling.
Project description
The proper function of our gut is controlled, in an involuntary fashion, by a complex network of nerves called the enteric nervous system (ENS), also known as the ‘second brain’. The ENS is produced in embryos by specialised cell populations known as ENS progenitors. A number of developmental defects (such as Hirschsprung disease) and adult conditions (e.g. Parkinson’s disease) are associated with defective ENS development and subsequent dysfunction. It is therefore essential to understand the mechanisms guiding the transition of ENS progenitors toward their derivatives. Notch signalling is a key pathway controlling this process and mutations in its components lead to Hirschsprung disease. In this project, we will employ a systems biology approach, iterating between a human pluripotent stem cell (hPSC)-based in vitro model of ENS development and an in silico computational model, to determine the role of Notch in ENS progenitor biology.
About the DTP
This studentship is offered as part of the White Rose BBSRC Doctoral Training Partnership (DTP) in Mechanistic Biology, which brings together the research of the world-class molecular and cellular bioscience centres at the White Rose universities of Leeds, Sheffield and York.
What is on offer?
This is a core/iCASE studentships for entry in October 2024.
Join us and you will receive a 4-year, funded PhD programme of research and skills training, with cross-disciplinary supervision, plus a structured programme of cohort-wide training and networking events. A highlight is the annual symposium, which is planned and delivered by students.
A unique part of your training will be the Professional Internships for PhD Students (PIPS), where you will spend three months at a host organisation of your choosing, gaining experience of work in a professional environment, and acquiring transferable skills that will be beneficial in your future career.
How to apply – Expression of Interest
Students may apply for up to three projects anywhere in the Doctoral Training Partnership (DTP). Applications will be to the DTP centrally, using an online Expression of Interest (EoI). The EoI will include:
-CV information; not submitted separately
-Equality, Diversity and Inclusion (EDI) data
-Names of two referees
Deadline for EoIs is midnight Sunday 7th January 2024.
Submit EoIs using this link: https://leeds.onlinesurveys.ac.uk/white-rose-bbsrc-dtp-expression-of-interest-form
Shortlisted candidates will be required to make formal applications to the Graduate School at each institution, supplying the necessary paperwork.
Interviews will be held either Friday 2nd and Monday 5th to Friday 9th February, or Monday 19th to riday 23rd and Monday 26th February 2024, in-person at Leeds, Sheffield and York, with a panel representing all 3 Universities. Shortlisted candidates will be notified of a specific time/date to attend. If you have applied for more than one project and are selected for interview, you will be interviewed only once.
Funding Notes
Appointed candidates will be fully funded for 4 years:
-Tax-free annual stipend at the UKRI rate. The rate for starters in 2023/24 was £18,622. (Rates for 2024/25 starters are not yet available).
-UKRI tuition fees – These are paid directly to the host institution.
-A Research Training and Support Grant
-An allowance for Fieldwork/Conference/Travel
-A Professional Internship for PhD Students (PIPS) allowance
Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.
Closing Date: 7 January 2024
Duration: Permanent