PhD Position on Primordial Germ Cell Heterogeneity (University of Copenhagen)

A cell’s epigenome is composed of its cell type-specific chromatin landscape and acts to preserve cell identity. In mammals, primordial germ cells (PGCs), the precursors to male and female gametes, experience the most extensive epigenetic reprogramming of any cell type. This reprogramming erases the chromatin landscape that defines somatic cells and prevents deleterious epimutations from being passed to the next generation. This reprogramming is crucial for proper differentiation, and there is evidence that it proceeds heterogeneously in the PGC pool. However, our understanding of the interplay between reprogramming and germ cell development remains limited.

This project will investigate epigenetic reprogramming in mouse PGCs. The successful candidate will have opportunity to learn embryology, mouse genetics, stem cell culture, cutting-edge genomics, and bioinformatics, as well as participate in development of imaging and flow cytometry methods.

The Stewart-Morgan lab is interested in epigenetic dynamics and function in germ cell biology. We use both in vivo and in vitro models of mammalian gametogenesis to study the role of the epigenome in germ cell fitness and elucidate general epigenetic principles using this unique biological system. We strive for an open, collaborative and collegial work environment that provides ample mentorship and training opportunities to further each members’ individual career goals.

Previous experience in next generation sequencing, imaging, flow cytometry, stem cell culture, and/or mouse genetics is an advantage. All necessary training will be provided to help you succeed.

The PhD is fully funded for 4 years. We are located at the Department of Cellular and Molecular Medicine (ICMM) in the heart of Copenhagen. ICMM is a highly collaborative environment with state-of-the-art facilities and hosts strong expertise in germ cell biology and functional genomics. We are in close proximity to and collaborate with other renowned research centers, including NNF-CPR and NNF-reNEW. We are a young and dynamic team, and the successful candidate will play an integral role in establishing the lab and research environment.

For more information, see the job advertisement or contact Associate Professor Kathleen Stewart-Morgan (kathleen@sund.ku.dk).

To apply, please follow the application procedure described in the job advertisement: https://employment.ku.dk/phd/?show=158243