Post-doctoral researcher in molecular biology – Maurange Lab, IBDM, Marseille, France
Posted by Delphine Dauga, on 20 June 2023
Location: Marseille, France
Closing Date: 7 July 2023
A post-doctoral position in molecular biology is open for recruitment within the “Neural Stem Cell Plasticity” team (2 years + 1 year renewable) to study how microRNAs regulate the cellular hierarchy of pediatric tumors.
The successful candidate will work on a pediatric brain tumor model developed in Drosophila (PMID: 27296804 ; PMID: 31566561 ; PMID: 35544555). He/she will use a new technology developed by the team enabling in vivo isolation of microRNAs expressed at different stages of the cell hierarchy.
Bioinformatic analysis of the microRNAs will enable us to identify modules specifically targeting the regulators of the tumor cell hierarchy. The generation of “multi-sponge” transgenic lines will enable inactivation of the microRNA module targeting the regulators of the cell hierarchy. This study will provide proof of concept that the inactivation of microRNA modules can be used as a therapeutic means of controlling tumor cell hierarchy with a view to eliminating cancer stem cells.
The post-doc will benefit from the scientific environment of IBDM, a world-renowned institute working on embryonic development and associated diseases.
Activities
- Drosophila genetics
- Purification of microRNAs
- Cloning
- Basic bioinformatics analysis
- Immunolabeling and confocal microscopy analysis
Progress will be regularly presented in English at team meetings and scientific conferences.
Skills
In addition to their own motivation and enthusiasm to participate in the advancement of scientific knowledge, the successful candidate will need to have the following skills or experience:
Skills required:
- Molecular biology techniques (RNA extraction, cloning, immunochemistry, immunoprecipitation)
- Solid knowledge of cell biology, developmental biology and cancer
- Ability to discuss and write in English
Skills appreciated but not mandatory:
- Drosophila genetics
- Bioinformatics (sequencing data alignment, enrichments etc)
Profile required
- Recent PhD in molecular biology
- Good communication skills
- Ability to work as part of a team, good listening and reading skills
Contact
Closing Date: 7 July 2023
Scientific fields: Stem cells
Model systems: Drosophila
Duration: Permanent