Senior Laboratory Research Scientist – The Francis Crick Institute

The Francis Crick Institute Developmental Signalling Laboratory, led by Caroline Hill, is seeking a highly motivated Senior Laboratory Research Scientist (SLRS) with expertise in zebrafish development to support ongoing projects in the lab as well as to lead their own independent research project. The successful candidate will manage day-to-day lab operations and the lab budget, train PhD students and postdocs, and will drive their own independent project focused on predominantly on using zebrafish as a disease model. They will also support other research in the lab where appropriate and help generate and maintain zebrafish lines. The successful candidate should be strongly motivated to do research as well as having good organisational skills to be able to successfully manage the lab operationally.

For more information about the lab and current research see https://www.crick.ac.uk/research/labs/caroline-hill

For some recent publications see:    https://pubmed.ncbi.nlm.nih.gov/34737283/

https://pubmed.ncbi.nlm.nih.gov/34003511/

https://pubmed.ncbi.nlm.nih.gov/33416497/

https://pubmed.ncbi.nlm.nih.gov/29275993/

The main project that the SLRS will focus on concerns determining how deregulated TGF-β family signalling leads to diseases such as the Marfan syndromes. The SLRS will use CRISPR/Cas9 editing in zebrafish embryos to generate zebrafish models of these diseases to unravel the underlying molecular mechanisms. Candidates with a strong proven expertise in zebrafish embryology and genetics and in molecular biology are encouraged to apply.

Key responsibilities

These include but are not limited to:

• Carrying out research projects independently and in collaboration with other members of the lab.
• Generating and maintaining zebrafish lines
• Lab management – day-to-day operation of the lab, e.g. ordering reagents, equipment care, managing the lab budget, database management etc
• Representing the lab when necessary in the Institute
• Training new lab members
• Support lab members, including PhD Students, providing advice and guidance as required

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential

Qualifications, experience and competencies:

• PhD in developmental biology
• Good knowledge and experience of working with zebrafish as a developmental system and technical expertise in zebrafish embryology and imaging
• Good knowledge and experience of molecular biology
• Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals
• Ability to work independently and also in a team
• Strong organisational skills and thorough record-keeping
• Excellent oral and written communication skills and the ability to provide feedback and guidance to other lab members and teams where needed
• Good interpersonal skills enabling the postholder to influence and build effective relationship both within the lab and in collaboration with colleagues
• Strong interest in pursuing independent research
  

Desirable

Qualifications, experience and competencies:

• Experience in signal transduction research
• Experience with mouse models