Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv and arXiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Environment, evolution and development

Cell Biology

Modelling

Tools & Resources

Developmental biology

| Patterning & signalling

FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation

Ilya Chuykin,Sergei Y. Sokol

Retinal Calcium Waves Coordinate Uniform Tissue Patterning of the Drosophila Eye

Ben Jiwon Choi, Yen-Chung Chen,Claude Desplan

Wnt11 Positively Regulates Neonatal Cardiomyocyte Maturation at the Interphase of Life via Frizzled 4 Receptor

Xuedong Kang, Joan Moci, Charlotte Wolf,Marlin Touma

Lifelong development of zebrafish gills: Asymmetries in early vascular patterning predict adult gill architecture

Mathieu Preußner, Anna Mertens, Marion Basoglu,Virginie Lecaudey

Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

Ravindra B. Chalamalasetty, Haley Tran, Ryan Kelly, Samuel Kuo,Mark W. Kennedy,Moonsup Lee, Sara Thomas,Nikolaos Mandalos,Vishal Koparde,Francisco Pereira Lobo,Terry P. Yamaguchi

A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics

Camilla Autorino,Diana Khoromskaia,Louise Harari, Elisa Floris, Harry Booth,Cristina Pallares-Cartes, Vesta Petrasiunaite,Michael Dorrity,Bernat Corominas-Murtra,Zena Hadjivasiliou,Nicoletta I. Petridou

Direct cell-to-cell transport of Hedgehog morphogen is aided by the diffusible carrier Shifted/DmWif1

Carlos Jiménez-Jiménez,Gustavo Aguilar,Clara Fernández-Pardo,Markus Affolter,Isabel Guerrero

The anti-neural role of BMP signaling is a side effect of its global function in dorsoventral patterning

Paul Knabl, June F. Ordoñez,Juan Daniel Montenegro Cabrera,Tim Wollesen,Grigory Genikhovich

A novel self-organizing embryonic stem cell system reveals the role of Wnt signaling parameters in anterior-posterior patterning of the nervous system

Siqi Du,Aryeh Warmflash

Rapid transcriptional response to a dynamic morphogen by time integration

Susanna E. Brantley, Jacqueline Janssen, Anna Chao, Massimo Vergassola, Shelby A. Blythe,Stefano Di Talia

Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis

Changle Zhao, Yongxun Chen, Lei Liu, Xiang Liu, Hesheng Xiao, Feilong Wang, Qin Huang, Xiangyan Dai, Wenjing Tao, Deshou Wang,Jing Wei

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling

Miriam Gordillo, Rebecca Wu, Kelly M. Banks, Neranjan de Silva,Todd Evans

TFAP2A+ embryonic progenitor cells undergo fate diversification to give rise to human amnion, germline, and mesoderm

Auriana Arabpour, Jonathan Adam DiRusso, Qiu Ya Wu, Mark Larsen, Young Sun Hwang, Elsie Jacobson, Thi Xuan Ai Pham, Nicole Agranonik, Megan Sparrow, Vernon Leander Monteiro, Zenya Rebecca Bian, Nicolas Pelaez-Restrepo, Antuca Callejas-Marin,Vincent Pasque,Kathrin Plath, Amander T. Clark

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning

Anastasios Balaskas,Isabelle Kraus, Hatice Ö. Özgüldez,Persia Akbari Omgba,René Buschow,Adriano Bolondi,Idan Berlad,Jacob H. Hanna,Helene Kretzmer,Aydan Bulut-Karslioğlu

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast

Elizabeth Abraham, Thomas Roule, Aidan Douglas, Emily Megill, Olivia M. Pericak, Jordan E. Howe, Carmen Choya-Foces, Joanne F. Garbincius, Henry M. Cohen, Paula Roig-Flórez, Mikel Zubillaga, Mark D. Andrake, Seonhee Kim, John W. Elrod, Naiara Akizu, Conchi Estaras

| Morphogenesis & mechanics

In vivo nuclear envelope adaptation during cell migration across confining embryonic tissue environments

Hanna-Maria Häkkinen,Soraya Villaseca, Zain Alhashem, Szymon Chomiczewski, Maxime Desevedavy, Solene Leleux, Atrin Hamidzadeh, Filomena Gallo, Dina El-Zohiry, Victor Petre,Elena Scarpa

Embryonic development of C. elegans sense organs

Leland R. Wexler,Irina Kolotuev,Maxwell G. Heiman

Transient epithelial mimicry reconciles stemness and regional specification in neural crest cells of avian beaks

Carmen Sánchez Moreno,Alexander V. Badyaev

A method for analysing tissue motion and deformation during mammalian organogenesis

Morena Raiola, Isaac Esteban,Kenzo Ivanovitch, Miquel Sendra,Miguel Torres

Mechanosensitive localization of Diversin highlights its function in vertebrate morphogenesis and planar cell polarity

Satheeja Santhi Velayudhan, Chih-Wen Chu, Keiji Itoh,Sergei Y. Sokol

Stiffness sensing fuels matrix-driven metabolic reboot for kidney repair and regeneration

Yuan Gui, Yuanyuan Wang, Wenxue Li, Jia-Jun Liu, Kelly Zheng, Jianzhong Li, Henry Wells Schaffer, Cameron Jones, Samantha Mae Mallari,Yanbao Yu, Silvia Liu,Yansheng Liu,Dong Zhou

Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity

Jian Xiong Wang,Yanina D. Alvarez,Siew Zhuan Tan,Samara N. Ranie,Samantha J. Stehbens,Melanie D. White

Resilience in zebrafish embryoids

Svetlana Jovanic, Julia Eckert, Thierry Savy,Nadine Peyrieras

Maternal exercise rescues fetal akinesia-impaired joint and bone development

Christopher J. Panebianco, Yuming Huang,Nidal Khatib,Devin C. Gottlieb,Maha Essaidi,Saima Ahmed,Nathaniel A. Dyment,Rebecca A. Simmons,Joel D. Boerckel,Niamh C. Nowlan

| Genes & genomes

piRNAs are abundant in the early embryo of the crustacean Parhyale hawaiensis

Llilians Calvo,Tom Pettini,Guillem Ylla,Matthew Ronshaugen,Sam Griffiths-Jones

Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK

Rose M. Doss, Sara A. Wirth, Jonathan W. Pitsch, Caroline M. Dias, Andrea L. Gropman, Martin W. Breuss

WAGO-1 is a sexually dimorphic Argonaute protein required for proper germ granule structure and gametogenesis

Acadia L. DiNardo, Nicole A. Kurhanewicz, Hannah R. Wilson, Veronica Berg,Diana E. Libuda

prdm1a drives a fate switch between hair cells of different mechanosensory organs

Jeremy E Sandler, Ya-Yin Tsai, Shiyuan Chen, Logan Sabin, Mark E. Lush, Abhinav Sur, Elizabeth Ellis, Nhung TT Tran, Malcolm Cook, Allison R Scott, Jonathan S. Kniss,Jeffrey A. Farrell, Tatjana Piotrowski

Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea

Junichi Tasaki,Labib Rouhana

Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity

Hyunwook Lee, Abigail Jaquish, Sharlene Fernandes, Barbara Zhao, Amber Elitz, Kathleen Cook, Sarah Trovillion,Natalia Bottasso-Arias, Simon J. Y. Han, Samantha Goodwin, Nicholas X. Russell,Amanda L. Zacharias, Samantha A. Brugmann,Jeffrey A. Whitsett,Debora Sinner, Xin Sun, Daniel T. Swarr,William J. Zacharias

Molecular profiling of bovine primordial germ cell specification and migration onset reveals a conserved program in bilaminar disc embryos

Carly Guiltinan,Ramon C. Botigelli,Rachel B. Arcanjo,Juliana I. Candelaria, Lawrence F. Lanzon, Justin M. Smith, Gloria Becerra-Cortes,Anna C. Denicol

Neuronal migration induces DNA damage in developing brain

Zhejing Zhang, Andres Canela, Peilin Zou, Takahiro Furuta, Noriko Takeda, Takumi Kawaue,Naotaka Nakazawa, Mai Saeki, Masaki Utsunomiya, Junko Kurisu, Fumiyoshi Ishidate, Hiroyuki Sasanuma,Yusuke Kishi, Mineko Kengaku

Loss of Meiotic Double Strand Breaks Triggers Recruitment of Recombination-independent Pro-crossover Factors in C. elegans Spermatogenesis

JoAnne Engebrecht,Aashna Calidas,Qianyan Li,Angel Ruiz, Pranav Padture, Consuelo Barroso, Enrique Martinez-Perez,Nicola Silva

Single-cell omics reveal distinct gene regulatory dynamics underpinning embryonic and extraembryonic lineage functions during pig blastocyst development

Adrien Dufour,Marie-Noëlle Rossignol, Patrick Manceau, Yoann Bailly,Stéphane Ferchaud,Marie-José Mercat,Ali G Turhan,Sarah Djebali,Sylvain Foissac,Jérôme Artus,Hervé Acloque

Major waves of H2A.Z incorporation during mouse oogenesis

Madeleine Fosslie, Erkut Ilaslan, Trine Skuland, Adeel Manaf, Mirra Louise Cicilie Soegaard, Marie Indahl, Maria Vera-Rodriguez, Rajikala Suganthan, Ingunn Jermstad, Shaista Khanam, Knut Tomas Dalen,Ragnhild Eskeland, Michel Choudalakis, Magnar Bjoras, Peter Zoltan Fedorcsak, Gareth David Greggains, Mika Zagrobelny,John Arne Dahl,Mads Lerdrup

Somatic gene repression ensures physical segregation of germline and soma in Drosophila embryos

Miho Asaoka, Mizuki Kayama, Tomoki Kawagoe,Makoto Hayashi, Shumpei Morita,Satoru Kobayashi

Core microRNAs regulate neural crest delamination and condensation in the developing trigeminal ganglion

Rocío B. Marquez,Estefanía Sánchez Vázquez,Andrés M. Alonso, Yanel E Bernardi,Emilio M. Santillan,Peter Lwigale,Luisa Cochella,Marianne E. Bronner,Pablo H. Strobl-Mazzulla

A porcine germ cell depletion model to investigate the role of germ cells in gonadal development

Chi-Hun Park, Young-Hee Jeoung, Sai Goutham Reddy Yeddula, JiTao Wang, Bhanu P. Telugu

Transgenerational effects induced by thiacloprid in Anterior prostate tissue are associated with alterations in DNA methylation at developmental genes

Ouzna Dali, Chaima Diba Lahmidi, Tayeb Mohammed Belkhir, Theo De Gestas, Christine Kervarrec, Pierre-Yves Kernanec,Fatima Smagulova

The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness

Pavel A. Komarov, Philipp Bammer,Ching-Yeu Liang,Hans-Rudolf Hotz,Grigorios Fanourgakis,Sunwoo Chun,Hubertus Kohler,Tim-Oliver Buchholz,Jean-Francois Spetz,Antoine H.F.M Peters

Slit1 -a MET target gene in the embryonic limbs, prevents premature differentiation during mammalian myogenesis

Masum Saini,Jyoti Jadhav,Giulio Cossu,Sam J. Mathew

A short conserved sequence in the HOT region of the C. elegans dlg-1 gene largely recapitulates its transcriptional behavior during embryogenesis

Cristina Tocchini, Palmer Bassett,Susan E. Mango

Single oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability during oocyte maturation

Yuqian Wang, Wei Wang, Yujun Liu, Yiming He, Hongyu Song, Ming Yang, Nan Wang, Xiaomeng Wang, Ling Ding, Ying Kuo, Yuwen Xiu, Zhengrong Du, Lu Chen, Ying Lian, Qiang Liu, Liying Yan, Jie Qiao, Peng Yuan

Due-B Is dispensable for early development and genome duplication in vertebrates

Courtney G. Sansam,Emily A. Masser,Duane Goins,Christopher L. Sansam

| Stem cells, regeneration & disease modelling

iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling

Joyce Esposito,Felipe de Souza Leite,Igor Neves Barbosa,Thaís Maria da Mata Martins, Giovanna Gonçalves de Oliveira Olberg,Ziad Al Tanoury,Kayque Alves Telles-Silva,Mayana Cristina da Silva Pardo,Tatiana Jazedje,Raul Hernandes Bortolin,Mario Hiroyuki Hirata,Olivier Pourquié,Mayana Zatz

A window of cell cycle plasticity enables imperfect regeneration of an adult postmitotic organ in Drosophila

Navyashree A Ramesh,Laura Buttitta

TGF-beta coordinates changes in Keratin gene expression during complex tissue regeneration

Dipak D Meshram, Yuchang Liu, Molly Worth, Changqing Zhang,Tom J. Carney, Henry H. Roehl

Heterogeneity of Sox2-expressing cells in mouse pituitary and their roles in postnatal gonadotroph differentiation

Kosara Smiljanic,Stephanie Constantin,Naseratun Nessa,Stanko S. Stojilkovic

WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm

Bao Q. Thai, Stephanie A. Luff, Jared M. Churko, Jonathan N. Young, Christopher M. Sturgeon,Deepta Bhattacharya

SWI/SNF ATPase Brahma and Notch signaling collaborate with CBP/p300 to regulate neural stem cell apoptosis in Drosophila larval central nervous system

Punam Bala,Viswadica Prakki,Rohit Joshi

Modeling Post-Gastrula Development via Bidirectional Pluripotent Stem Cells

Kuisheng Liu, Zihui Yan, Dandan Bai, Rui Jiang, Yan Bi, Xiangjun Ma, Jiani Xiang, Yifan Sheng, Baoxing Dong, Zhiyuan Ning, Shanru Yi, Yingdong Liu, Xinyi Lei, Yanping Jia, Yan Zhang, Yalin Zhang, Yanhe Li, Chenxiang Xi, Shanyao Liu, Shuyi Liu, Jiayu Chen, Jiqing Yin, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yixuan Wang, Ke Wei, Wenqiang Liu,Shaorong Gao

Primitive Hepatoblasts Driving Early Liver Development

Kentaro Iwasawa, Hiroyuki Koike, Hasan Al Reza, Yuka Milton, Keishi Kishimoto, Konrad Thorner, Marissa Granitto, Norikazu Saiki, Connie Santangelo, Kathryn Glaser, Masaki Kimura, Alexander Bondoc, Hee-Wong Lim, Mitsuru Morimoto, Makiko Iwafuchi, James M. Wells, Aaron M. Zorn,Takanori Takebe

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers

Martina Demurtas, Samantha M. Barnada, Emma van Domselaar, Zoe H. Mitchell, Laura Deelen,Marco Trizzino

Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members

Allara K. Zylberberg,Emma I. Scully,Pei Xuan Er, Hannah Baric, Michelle Scurr,Mian Xie,Thanushi Peiris,Sara E. Howden,Kynan T. Lawlor,Melissa H. Little

ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity

Angelica Varesi, Murtaza S. Nagree, Isabella Di Biasio, Andy G.X. Zeng, Sayyam Shah, Hyerin Kim, Michael Zhang, Alex Murison, John E. Dick,Stephanie Z. Xie

ankrd1a consistently marks cardiomyocytes bordering the injury or scar area and affects their dedifferentiation during zebrafish heart regeneration after cryoinjury

Srdjan Boskovic,Mirjana Novkovic,

Asperous coordinates regenerative timing by regulating damage-induced WNT Signaling

Si Cave,Manashi Sonowal,Chloe Van Hazel,Petra Fromme,Robin E. Harris

The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation

Hideyuki Sato,Ayaka Yanagida, Mariko Kasai,Naoaki Mizuno,Eiji Mizutani, Hiromi Yamamoto,Satoko Ishii, Taro Hihara,Kazuto Yamazaki, Ayuko Uchikura, Kazuaki Nakano, Masashi Ito,Hiroshi Nagashima,Hideki Masaki,Hiromitsu Nakauchi

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Daniel P. Moore, Heather B. Steele-Stallard, Luca Pinton, Valentina Maria Lionello, Lucia Rossi, Artadokht Aghaeipour, Salma Jalal, Cherry Tsz Yan Wong, Angela Clara-Hwang, Gisèle Bonne, Peter S. Zammit,Francesco Saverio Tedesco

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug Screening

Ashis Kumar, Vignesh Kumar, Agnes Selina, Vrisha Madhuri, Vasanth Thamodaran

| Plant development

Maternal control of RNA decay safeguards embryo development

Gerardo Del Toro-De León, Maria Sofia Trenti, Varsha Vasudevan, Ursula Krause,Claudia Köhler

Redesigning petal shape, size, and color in soybean reveals unexpected phenotypes for floral organ development

Nicole Szeluga, Noor AlBader, Samantha Pelletier, Kylie Weis, Arielle Johnson, Noah Fahlgren,Mikhaela Neequaye, Gus Vogt, Ryan DelPercio,Patricia Baldrich, Kelsey J.R.P. Byers,Blake C. Meyers,Margaret H. Frank

FLOE1 maintains cellular viscosity in rehydrating Arabidopsis embryos

Sterling Field, John F. Ramirez, Yanniv Dorone, Jack A. Cox, Thomas C. Boothby,Seung Y. Rhee

Analysis of Wheat Spike Morphological Traits Using 2D Imaging

Fujun Sun, Shusong Zheng, Zongyang Li, Qi Gao, Ni Jiang

Cytokinin overcomes spikelet-driven inhibition of tillering in wheat and barley by delaying meristem development

Alex Wakeman,Tom Bennett

FERONIA defines intact tissue boundaries through cuticle development

Gayeon Kim, Jeongho Choi, Ryeo Jin Kim, Eunkyoo Oh, Seung Yong Shin, Hyun-Soon Kim, Hye Sun Cho, Mi Chung Suh, Hyo-Jun Lee

Urbanization drives genetic and plastic responses of the spotted jewelweed flower morphology

Jerome Burkiewicz, Julie Carvalho, Sophie Caporgno,Joelle Lafond, Celine Devaux, Etienne Normandin, Simon Joly

Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis

Yanru Li,Danli Fei, Jasmin Schubert,Kinga Rutowicz,Zuzanna Kaczmarska, Alberto Linares,Alejandro Giraldo Fonseca,Sylvain Bischof,Ueli Grossniklaus,Célia Baroux

Gene regulatory network analysis of somatic embryogenesis identifies morphogenic genes that increase maize transformation frequency

Jim Renema,Svitlana Lukicheva, Isabelle Verwaerde,Stijn Aesaert,Griet Coussens,Jolien De Block,Carolin Grones,Thomas Eekhout,Bert De Rybel,Rhoda A.T. Brew-Appiah, Christopher A. Bagley,Lennart Hoengenaert,Klaas Vandepoele,Laurens Pauwels

Arabidopsis RabGDIs are essential for the asymmetric division of zygotes and embryonic patterning

Gui-Min Yin, Ya-Nan Wu, Weiqi Wang, Shan-Shan Dun, Sha Li, Liwen Jiang, Zi-zhen Liang,Yan Zhang,Feng Xiong

Antagonistic and Synergistic Roles of Tomato AFP3 Isoforms in Hormonal Regulation and Development

Ylenia Vittozzi,Louise Petri, Maurizio J. Chiurazzi, Purificación Lisón,Carmen Grech Hernández, Adity Majee, Naveen Shankar, Meike Burow,Stephan Wenkel

Lf2 is a knotted homeobox regulator that modulates leaflet number in soybean

Chancelor B. Clark,Denise Caldwell, Qiang Zhu, Dominic Provancal, Austin C. Edwards, Qijian Song, Charles V. Quigley,Anjali S. Iyer-Pascuzzi, Jianxin Ma

| Environment, evolution and development

Projected warming disrupts embryonic development and hatch timing in Antarctic fish

Margaret Streeter,Nathalie R. Le François,Thomas Desvignes, Jacob Grondin,John H. Postlethwait,H. William Detrich III,Jacob M. Daane

Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida

Allan M. Carrillo-Baltodano,Emmanuel Haillot,Steffanie Mutiara Meha, Imran Luqman, Artenis Pashaj, Yun-Ju Lee,Tsai-Ming Lu,David E. K. Ferrier,Stephan Q. Schneider,José M. Martín-Durán

A tardigrade cytochrome P450 perturbs Drosophila melanogaster development

Caitlyn L Perry, Charles Robin

Cellular and transcriptional trajectories of neural fate specification in sea anemone uncover two modes of adult neurogenesis

Flora Plessier,Heather Marlow

Differential fates of vertebrate Kazald gene quartet, from ancestral roles in skeletogenesis and regeneration to putative innovations in fish and birds

Sean D. Keeley,Rita Aires,Belfran Alcides Carbonell Medina,Claudia Marcela Arenas-Gómez,Alejandra Cristina López-Delgado,Jean Paul Delgado,Franziska Knopf,Shigehiro Kuraku,Tatiana Sandoval-Guzmán

Wound-induced eyespots on butterfly wings at the intersection of immune response and pigmentation development

Maria Adelina Jerónimo,Ana Rita Garizo,Guilherme W Atencio,David Duneau,Patrícia Beldade

Developmental plasticity of hermaphrodite sperm production across environments in Caenorhabditis elegans

Clotilde Gimond,Nausicaa Poullet,Anne Vielle, Emilie Demoinet,Christian Braendle

The evolution of gene regulatory programs controlling gonadal development in primates

Nils Trost,Amir Fallahshahroudi,Ioannis Sarropoulos,Céline Schneider,Julia Schmidt,Noe Mbengue, Eva Wolff, Charis Drummer,Robert Frömel,Steven Lisgo,Florent Murat,Mari Sepp,Margarida Cardoso-Moreira,Rüdiger Behr,Henrik Kaessmann

On wing pattern and wing shape evolution in Giant Silk Moths: Lessons from wing development in Luna and Polyphemus Moths

Andrei Sourakov

Cell Biology

Biological characteristics of rabbit KLF12 and its regulation of proliferation and apoptosis of ovarian granulosa cells

Jiawei Cai, Bohao Zhao, Zhiyuan Bao, Yunpeng Li, Xiaoman Han, Yang Chen,Xinsheng Wu

Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum

Zaili Luo, Mingyang Xia, Feng Zhang, Dazhuan Xin, Rohit Rao, Karrie M. Kiang, Kalen Berry, Yu Xiong, Hongqi Liu, Yifeng Lin, Ming Hu, Mei Xin, Jie Ma, Hao Li, Michael D. Taylor, Wenhao Zhou, Q. Richard Lu

Post-replicative initial expression of the cell fate regulator PAX6 during neuroectoderm differentiation

Song Hu, Rongao Kou, Zhuojie Su, Guanchen Li, Shutao Qi, Yanxiao Zhang, Haifeng Wang, Ling-Ling Chen, Hongtao Yu

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function

Chenhao Tong, Tao Lin, Han Wang, Carolina De La Torre, Hui Liu, Chen Shao, Seddik Hammad, Roman Liebe, Matthias P Ebert, Huiguo Ding, Steven Dooley, Hong-Lei Weng

The Sphingosine-1-phosphate pathway is differentially activated in human gestational tissuesv

Magdaleena Naemi Mbadhi, Hideji Fujiwara, Ruth Gill, Kaci T. Mitchum, Cici Lin,Nandini Raghuraman,Antonina I. Frolova

Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

Haruna Gekko, Ruri Nomura, Daiki Kuzuhara, Masato Kaneyasu, Genpei Koseki, Deepak Adhikari, Yasuyuki Mio, John Carroll, Tomohiro Kono, Hiroaki Funahashi,Takuya Wakai

“PDGFRα is required for postnatal cerebral perivascular fibroblast development”

Hannah E. Jones, Kelsey A. Abrams,Katherine A. Fantauzzo,Julie A. Siegenthaler

Aberrant placental structure is corrected with repeated nanoparticle-mediated IGF1 treatments in a guinea pig model of fetal growth restriction

Baylea N. Davenport,Rebecca L. Wilson, Alyssa A. Williams, Jaimi A. Gray, Edward L. Stanley, Helen N. Jones

Pcbp1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition

E. I. Bakhmet,E. V. Potapenko,O. Y. Shuvalov,A. A. Lobov,E. A. Repkin,N. E. Vorobyeva, A. N. Korablev,A. S. Zinovyeva, A. A. Kuzmin,N. D. Aksenov,A. T. Kopylov,G. Wu,H. R. Schöler,A. N. Tomilin

Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta

Siddharth Acharya,Eric Hanssen,Veronica B. Botha, Tia M. Smith,Sahan Jayatissa, Zlatan Trifunovic,Lucy A. Bartho,John E. Schjenken,Tu’uhevaha J. Kaitu’u-Lino,Anthony V. Perkins,Joanna L. James,Kirsty G. Pringle,James C. Bouwer,Roger Smith,Joshua J. Fisher

Developmental coordination of mitochondrial dynamics and membrane remodeling drives organelle morphogenesis

H Aravind, Vivek Kumar, Manish Jaiswal

Patched regulates cell cycle and tissue architecture in C. elegans gonad

Johanna Farley, Madeleine Schwalbe, Fredrik Forsberg, Aqilah Amran,Sandeep Gopal

Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle

Suma Garibova, Eva Stickler, Fatima Al Ali, Maha A Abdulla, Abbirami Sathappan,Sahar Da’as, Lilian Ghanem, M Nadhir Djekidel, Rick Portman,Matteo A Avella

Juvenile hormone degradation enzymes have shared and unique requirements in Drosophila development

Harry Siegel,Creehan Healy,Krystal Goyins,Amina Jumamyradova, Jie Ying,Alexey A Soshnev,Rebecca F Spokony,Lacy J Barton

MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis

Esther G. Ushuhuda, Jenniluyn T. Nguyen, Natalie G. Pfaltzgraff, Matthew Kofron,Maria M. Mikedis

Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations

Anna Frey,Laurin Ernst,Friedericke Fischer,Lale Alpar, Yohanns Bellaïche,Anne-Kathrin Classen

Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells

Abhrajit Ganguly, Cynthia M Carter, Aristides Rivera Negron, Hua Zhong, Alvaro Moreira, Matthew S. Walters, Lynette K Rogers, Y S Prakash, Trent E Tipple, Arlan Richardson

Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through intrinsic apoptosis in the neonatal lung

Melinda E. Snitow, Sylvia N. Michki, Fatima N. Chaudhry, Rachna Dherwani, Jeremy B. Katzen, David B. Frank, Jarod A. Zepp

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development

Shalini Chakraborty, Jack Govaerts, Abigail Hawke, Matthew Werbelow,Todd Schoborg

Taurine Transporter SLC6A6 Expression Promotes Mesenchymal Stromal Cell Function

Christina M. Kaszuba, Sonali Sharma, Benjamin J. Rodems, Cameron D. Baker, Palomi Schacht, Takashi Ito, Kyle P. Jerreld, Chen Yu, Edgardo I. Franco, Emily R. Quarato, Francisco A. Chaves, Jane L. Liesveld, Laura M. Calvi, Hani A. Awad, Roman A. Eliseev,Jeevisha Bajaj

Protein kinase C inhibitor suppresses 2-cell stage development and perinuclear vesicle formation in mouse zygotes

Toru Suzuki, Yuriko Sakamaki

Dolutegravir Developmental Toxicity is Mitigated by Magnesium and Folate in Zebrafish Embryos

Robert M Cabrera, Ahmed Mohamed, Ryoko Minowa, Katheryn A Neugebauer,Daniel A Gorelick

Stay or Stray: Lpar1 regulates neutrophil retention and epidermal homeostasis in early zebrafish development

Shih-Chi Li, Yu-Chi Lin,Chung-Der Hsiao,Shyh-Jye Lee

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages

Eloïse Bertiaux, Vincent Louvel, Caitlyn L. McCafferty, Hugo van den Hoek, Umut Batman, Souradip Mukherjee,Lorène Bournonville, Olivier Mercey, Isabelle Mean, Adrian Müller, Philippe Van der Stappen, Garrison Buss, Jean Daraspe,Christel Genoud, Tim Stearns,Benjamin D. Engel,Virginie Hamel,Paul Guichard

Modelling

BlastDiffusion: A Latent Diffusion Model for Generating Synthetic Embryo Images to Address Data Scarcity in In Vitro Fertilization

Alejandro Golfe, Natalia P. García-de-la-puente, Adrián Colomer, Valery Naranjo

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos

Xin Li, Robert J. Huebner, Margot L.K. Williams, Jessica Sawyer, Mark Peifer, John B. Wallingford, D. Thirumalai

Generative epigenetic landscapes map the topology and topography of cell fates

Victoria Mochulska,Paul François

Tools & Resources

A cell atlas of the developing human outflow tract of the heart and its adult derivatives

Rotem Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, John Dark, Andrew D Sharrocks, Karen Piper Hanley, Neil A Hanley, Magnus Rattray, Simon D Bamforth, Nicoletta Bobola

A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability

Stanley E. Strawbridge,Lawrence E. Bates, Connor Ross, Kenneth A. Jones,Takuya Azami,Tim Lohoff,Maike Paramor, Vicki Murray,Ana Luíza Cidral, James Clarke,Maria Rostovskaya, Ge Guo,Jennifer Nichols

Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids

Keevon Flohr, Michael Janecek, Lingyun Wang, Vicente Valle, Shaohua Pi, Rui T. Peixoto, Susana da Silva

Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells

Shinichiro Ogawa, Mina Ogawa, Jeff C Liu, Abolfazl Dadvar, Britney Tian, Xinyuan Zhao, Ian Fernandes, Kentaro Minegishi, Kenichiro Takase, Yuichiro Higuchi,Hiroshi Suemizu,Ian McGilvray,Sonya MacParland,Gary Bader

Long-term ex ovo culture of Caenorhabditis elegans embryos

Clover Ann Stubbert, Cherry Soe,Pavak Kirit Shah

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Ittetsu Nakajima, Mitsuyoshi Shimane, Grace Holmstrom, Yuichiro Miyaoka

FOXM1 Inhibition Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway

Kayque Alves Telles-Silva, Lara Pacheco, Sabrina Komatsu, Fernanda Chianca, Gustavo Chagas, Gabrielly Cristine Martins, Maria Gridina, Daria Panchenko, Valdemir Melechco Carvalho, Elia G. Caldini, Veniamin S. Fishman,Michelle Arkin, Ernesto Goulart, Mayana Zatz

Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora

Ramona Brunner, Mila Grinblat, Aurelie Moya, Sylvain Foret, David C Hayward, Bruno Lapeyre, Eldon E Ball,Ira Cooke,David J Miller

A method for creating custom 3D-printed molds to facilitate zebrafish imaging studies, including of cardiac development

James Christian Miller, Prashanna Koirala, Maria Fernanda Argote de la Torre, Marjan Farsi, Jaret Lieberth, Rabina Shrestha,Joshua Bloomekatz

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