Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Environment, evolution and development

Cell Biology

Modelling

Tools & Resources

Research practice and education

Developmental biology

| Patterning & signalling

Boundary-guided cell alignment drives mouse epiblast maturation

Takafumi Ichikawa, Pamela C. Guruciaga, Shuchang Hu, Steffen Plunder, Mei Makino, Marina Hamaji, Anniek Stokkermans, Shinjiro Yoshida, Anna Erzberger, Takashi Hiiragi

Chinmo is a novel regulator of differential Hippo signaling response within a single developing organ

Shreeharsha Tarikere, Tarun Kumar, Guillem Ylla, Cassandra G. Extavour

Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta

Hannah N. Gruner, C. J. Pickett, Jasmine Yimeng Bao, Richard Garcia, Akiko Hozumi, Tal Scully, Shaoyang Ning, Mavis Gao, Gia Bautista, Keren Maze, Karissa Lim, Tomohiro Osugi, Mae Collins-Doijode, Ofubofu Cairns, Gabriel Levis, Shu Yi Chen, TaiXi Gong, Honoo Satake, Allon Moshe-Klein, Eduardo D. Gigante, Yasunori Sasakura, Bradley Davidson

Competing regulatory modules control the transition between mammalian gastrulation modes

Alexandra E. Wehmeyer, Johanna K. Schmitt, Felix Eggersdorfer, Lea Zissel, Chiara M. Schröder, Mehmet Tekman, André Dias, Katrin M. Schüle, Simone Probst, Alfonso Martinez-Arias, Katie McDole, Sebastian J. Arnold

Receptor stoichiometry predicts artery-typical vulnerability to altered Notch signaling during smooth muscle differentiation

Sami Sanlidag, Noora Virtanen, Hesam Hoursan, Tommaso Ristori, Marika Sjöqvist, Sandra Loerakker, Cecilia Sahlgren

Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior

Rachel Misner, Amy Reilein, Daniel Kalderon

Spontaneous ectopic head formation enables reversal of the body axis polarity in microscopic flatworms

Katarzyna Tratkiewicz, Ludwik Gąsiorowski

NvashA function reveals temporal differences in neural subtype generation in cnidarians

Jamie A Havrilak, MingHe Cheng, Layla Al-Shaer, Whitney B Leach, Mia Yagodich, Dylan Faltine-Gonzalez, Michael J Layden

Directional alignment of different cell types organizes planar cell polarity

Masaki Arata, Hiroshi Koyama, Toshihiko Fujimori

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

Veranika Panasenkava, Jules Garreau, Hélène Guyodo, Farah Diab, Ariane Mahieux, Wilfrid Carré, Yann Verres, Emmanuelle Jullion, Sylvie Odent, Christèle Dubourg, Paul Rollier, Lauryane Dubos, Vanessa Ribes, Anne Camus, Marie de Tayrac, Valérie Dupé

Patterning defects in mice with defective ventricular wall maturation and cardiomyopathy

Javier Santos-Cantador, Marcos Siguero-Álvarez, José Luis de la Pompa

| Morphogenesis & mechanics

Molecular and Mechanical Signatures Contributing to Epidermal Differentiation and Barrier Formation

Alexandra Prado-Mantilla, Wenxiu Ning, Terry Lechler

FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrain

Rosanna C. G. Smith, Maryam Clark, Mireya Vazquez-Prada, Marc Astick, Kristina C. Tubby, Stephen R. Price

Ectodysplasin overexpression reveals spatiotemporally dynamic tooth formation competency in stickleback and zebrafish

Zoe Z. Chen, Sujanya N. Narayanan, Lena M. Stagliano, Peter Q. Huynh, Shivani Sundaram, Emma J. Mackey, Craig T. Miller, Tyler A. Square

An embryonic artery-forming niche reactivates in pulmonary arterial hypertension

Wen Tian, Timothy Ting-Hsuan Wu, Shenbiao Gu, Jason L. Chang, Cerianne Huang, Ryan Vinh, Adam M. Andruska, Kyle K. Song, Dongeon Kim, Yu Zhu, Seunghee Lee, Junliang Pan, Peter N. Kao, Tushar Desai, Lawrence S. Prince, Lindsay D. Butcher, Xinguo Jiang, Marlene Rabinovitch, Kristy Red-Horse, Mark R. Nicolls

Cse1l Regulates Neural Crest Cell Survival and is Critical for Craniofacial and Cardiac Development

Paul P. R. Iyyanar, Rolf W. Stottmann

Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis

Arthur Michaut, Alexander Chamolly, Olinda ALEGRIA, Carole Phan, Francis Corson, Jerome Gros

Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

Shuo Chen, Jinxiu Liang, Jie Yin, Weijia Zhang, Peijun Jiang, Wenyuan Wang, Xiaoying Chen, Yuanhong Zhou, Peng Xia, Fan Yang, Ying Gu, Ruilin Zhang, Peidong Han

Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms

Alicia Lardennois, Chaitanya Dingare, Veronika Duda, Petra A Klemmt, Constanze Heinzen, David Kleinhans, Thorsten Falk, Carsten Schelmbauer, Olivia Mozolewska, Sofia Papadopoulou, Jason J K Lai, Didier Y R Stainier, Virginie Lecaudey

Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly

Gina Castelvecchi, Linwei Li, Jimann Shin, Nanbing Li-Villarreal, Isa Roszko, Paul Gontarz, Tiandao Li, Bo Zhang, Diane Sepich, Lila Solnica-Krezel

Extracellular stiffness regulates cell fate determination and drives the emergence of evolutionary novelty in teleost heart

Sho Matsuki, Yusei Inoue, Ryuta Watanabe, Toshiyuki Mitsui, Yuuta Moriyama

A lateral tension model for mouse cranial neural tube closure

Juana De La O, Gabriel L. Galea, Adam C. Martin

Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction

Aurélien Villedieu, Olinda Alegria-Prévot, Carole Phan, Yu Ieda, Francis Corson, Jérôme Gros

Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium

Abhishek Mukherjee, Michael Hilzendeger, Arin Rinvelt, Sana Fatma, Megan Schupp, Damian Dalle Nogare, Ajay B Chitnis

Mechanical cues organize planar cell polarity during vertebrate morphogenesis and embryonic wound repair

Chih-Wen Chu, Satheeja Velayudhan, Jakob H. Schauser, Sapna Krishnakumar, Stephanie Yang, Keiji Itoh, Dominique Alfandari, Ala Trusina, Sergei Y. Sokol

Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis

Soham Basu, Petrus Steenbergen, Florian Gabler, Alexandre Paix, Paolo Ronchi, Gleb Bourenkov, Thomas Schneider, Jonas Hellgoth, Anna Kreshuk, Suat Özbek, Aissam Ikmi

| Genes & genomes

A single cell ATAC-seq atlas uncovers dynamic changes in chromatin accessibility during cell fate specification at the neural plate border

Eva Hamrud, Jacob Leese, Alexandre P Thiery, Ailin L. Buzzi, Alessandra Vigilante, James Briscoe, Andrea Streit

Tissue specific function of the Drosophila 7SK snRNP in controlling motoneuron synaptic growth

Giriram Mohana, Nastasja Kreim, Jean-Yves Roignant

Tbr2-Dependent Parallel Pathways Regulate the Development of Distinct ipRGC Subtypes

Takae Kiyama, Ching-Kang Chen, Halit Y. Altay, Yu-Jiun Chen, Leviette Sigala, Dan Su, Steven Eliason, Brad A. Amendt, Chai-An Mao

Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila

Patrick Hofe, Tynan Gardner, Stephen DiNardo, Lauren Anllo

Neural stem cell quiescence is actively maintained by the epigenome

Anna Malkowska, Jan Ander, Andrea H. Brand

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

Konrad Chudzik, Isabel Guerreiro, Samy Kefalopoulou, Alex Abraham, Magdalena Schindler, Alessa Ringel, Mario Nicodemi, Irina Solovei, Andrea M. Chiariello, Stefan Mundlos, Jop Kind, Michael I. Robson

DSB repair kinetics impair CRISPR-Cas9 editing in human embryos

Dieter Egli, Diego Marin, Nathan Treff, Stepan Jerabek, Julie Sung, Jia Xu, Jishnu Talukdar

Enhancer-driven regulatory network of forebrain human development provides insights into autism

Alexandre Jourdon, Jessica Mariani, Abhiram Natu, Feinan Wu, Boxun Li, Davide Capauto, Kevin T. Hagy, Scott Norton, Livia Tomasini, Alexias Safi, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Matthew P. Nelson, Daniel M. Ramos, Michael E. E. Ward, Anna Szekely, James C. McPartland, Kevin Pelphrey, Pamela Ventola, Katarzyna Chawarska, Charles A. Gersbach, Gregory E Crawford, Alexej Abyzov, Flora M. Vaccarino

A GATA factor radiation in Caenorhabditis rewired the endoderm specification network

Antonia C. Darragh, Rachel Weinstein, Jessica R. Bloom, Scott A. Rifkin

RNA Pol I activity maintains chromatin condensation and the H3K4me3 gradient essential for oogenesis, independent of ribosome production

Raquel Mejia-Trujillo, Qiuxia Zhao, Ayesha Rahman, Elif Sarinay Cenik

ACRC/GCNA is an essential protease that repairs DNA-protein crosslinks during vertebrate development

Cecile Otten, Marin Kutnjak, Christine Supina-Pavic, Ivan Anticevic, Vanna Medved, Marta Popovic

Polycomb repressive complex 2 regulates sexual development in Neurospora crassa

Abigail M. Deaven, Abigail J. Ameri-Solanky, Zachary A. Lewis

Oocyte mitochondria link maternal environment to offspring phenotype

Jason F. Cooper, Kim Nguyen, Darrick Gates, Emily Wolfrum, Colt Capan, Hyoungjoo Lee, Devia Williams, Chidozie Okoye, Kelsie Nauta, Ximena Sanchez-Avila, Ryan T. Kelly, Ryan Sheldon, Andrew P. Wojtovich, Nicholas O. Burton

A Conserved Domain of Cfap298 Governs Left-Right Symmetry Breaking in Vertebrates

Marvin Cortez, Cullen B Young, Katherine A Little, Daniel T Grimes, Danelle Devenport, Rebecca D Burdine

Transcriptional Repression of reaper by Stand Still Safeguards Female Germline Development in Drosophila

Masaya Matsui, Shinichi Kawaguchi, Toshie Kai

SOX2-VSX2 Co-Occupancy Shapes Retinal Neurogenesis Through Dynamic Chromatin Regulation

Fuyun Bian, Kimiasadat Golestaneh, Emily Davis, Abdullah Khan, Marwa Daghsni, Keevon Flohr, Silvia Liu, Susana da Silva, Len Pennacchio, Issam Aldiri

Investigating oncoprotein-mediated chromatin dysregulation in Drosophila melanogaster uncovers novel modifiers of the developmental impact of H3 K27M and EZHIP

Samuel D. Krabbenhoft, Tyler E. Masuda, Yadwinder Kaur, Truman J. Do, Siddhant U. Jain, Peter W. Lewis, Melissa M. Harrison

VAB-8/KIF26, LIN-17/Frizzled, and EFN-4/Ephrin, control distinct stages of posterior neuroblast migration downstream of the MAB-5/Hox transcription factor in Caenorhabditis elegans

Vedant D. Jain, Erik A. Lundquist

Functionally significant, novel variants of BMP4 are associated with isolated congenital heart disease

Jyoti Maddhesiya, Ritu Dixit, Ashok Kumar, Bhagyalaxmi Mohapatra

Genes for 5’mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration

Rejenae Dockery, Mateo Zevallos, Carson McNulty, Tessa Zecchino, Reece Ratermann, Richard White, Joseph Aaron Goldman

Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation

Bernard K. van der Veer, Colin Custers, Wannes Brangers, Riet Cornelis, Spyridon Champeris Tsaniras, Kobe De Ridder, Bernard Thienpont, Huiyong Cheng, Qiuying Chen, Daniel Kraushaar, Richard H. Finnell, Steven S. Gross, Kian Peng Koh

| Stem cells, regeneration & disease modelling

Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution

Takashi Ishida, Juliane Mercoli, Adam M. Heck, Ian Phelps, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-McKay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Dana L Jackson, Colleen Delaney, Shahin Rafii, Irwin D. Bernstein, Kimberly A. Aldinger, Birth Defects Research Laboratory (BDRL), Cole Trapnell, Helong G. Zhao, Brandon Hadland

Macrophage Migration Inhibitory Factor Suppresses Natural Killer Cell Response and Promotes Hypoimmunogenic Stem Cell Engraftment Following Spinal Cord Injury

Shenglan Li, Yiyan Zheng, Haipeng Xue, Haiwei Zhang, Jiayun Wu, Xiaohui Chen, Miguel Perez Bouza, Samantha Yi, Hongxia Zhou, Xugang Xia, Xianmin Zeng, Qi Lin Cao, Ying Liu

Subcellular Mass Spectrometry Reveals Proteome Remodeling in an Asymmetrically Dividing (Frog) Embryonic Stem Cell

Bowen Shen, Leena R. Pade, Fei Zhou, Peter Nemes

GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells

Cesi Deng (邓策思), Adedamola Elujoba-Bridenstine, Ai Tang Song, Rylie M. Ceplina, Casey J. Ostheimer, Molly C. Pellitteri Hahn, Cameron O. Scarlett, Owen J. Tamplin

Elevated mitochondrial metabolism in Down syndrome iPSCs reduces commitment to neuroectoderm

Beverly A Rothermel, Malay Chaklader, Guilherme H Souza Bomfim, Neil Jeju, Yingli Duan, Brian F Niemeyer, Joaquín Maximiliano Espinosa, Edwin Rosado-Olivieri, Weichun Lin, Rodrigo S Lacruz

Clonal analysis reveals differential PGC contributions to the early germline and ovarian reserve

Maya Pahima, Florence L. Marlow

Phased ERK function on muscle stem cell plasticity in axolotl

Chao Yi, Xinxin Liu, Liqun Wang, Li Song, Ji-Feng Fei

Epitenon-derived cells comprise a distinct progenitor population that contributes to both fibrosis and regeneration following acute flexor tendon injury in a spatially-dependent manner

Anne E.C. Nichols, Lauren Benoodt, Emmanuella Adjei-Sowah, Kyle Jerreld, Alexander Kollar, Constantinos Ketonis, Alayna E. Loiselle

Mesenchymal WNT2B is required for the development and function of the human intestine

Akaljot Singh, Holly M. Poling, Jennifer Foulke-Abel, Nambirajan Sundaram, Abid A. Reza, Sarah Joseph, Abrahim ElSeht, Kalpana Srivasta, Maksym Krutko, Christopher N. Mayhew, David T. Breault, James M. Wells, Jay Thiagarajah, Amy E. O’Connell, Olga Kovbasnjuk, Michael A. Helmrath

Modeling Friedreich’s ataxia with Bergmann glia-enriched human cerebellar organoids

Seungmi Ryu, Jason Inman, Hyenjong Hong, Vukasin M Jovanovic, Yeliz Gedik, Yogita Jethmalani, Inae Hur, Ty Voss, Justin Lack, Jack Collins, Pinar Ormanoglu, Anton Simeonov, Carlos A. Tristan, Ilyas Singeç

Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

Anahí Binagui-Casas, Anna Granés, Alberto Ceccarelli, Eleni Karagianni, Daniel Lopez Ramajo, Rosa Portero, Matthew French, Jen Annoh, Frederick C.K. Wong, Sally Lowell, Osvaldo Chara, Valerie Wilson

Single-cell analyses reveal scyphozoan conserved and specific genes contribution during tissue regeneration in two jellyfish

Yiqian Li, Sean T.S. Law, Wenyan Nong, Wai Lok So, Yichun Xie, Thomas C.N. Leung, Tse Ho Li, Joyce Tse, Ho Yin Yip, Oli Jin, Jordan Zhang, Apple PY Chui, Kwok Fai Lau, Akbar John, Zhen-peng Kai, William G. Bendena, Alexander Hayward, Yingying Wei, Ting Fung Chan, Sai Ming Ngai, Jerome HL H

A human-specific regulatory mechanism revealed in a preimplantation model

Raquel Fueyo, Sicong Wang, Olivia J Crocker, Tomek Swigut, Hiromitsu Nakauchi, Joanna Wysocka

Tet1 safeguards lineage allocation in intestinal stem cells

Antoine Gleizes, Nicolas V Janto, Sergei Bombin, Vivek Rao, Gurel Ari, Siyang Sun, Maria Fonseca, Adam D Gracz

Modeling tissue-resident macrophage development from mouse pluripotent stem cells

Ann K. Baako, Ragavi Vijayakumar, Daniel Medina-Cano, Zhaoquan Wang, Jesús Romero-Pichardo, Kelvin Fadojutimi, Stephanie C. Do, Yuan Lin, Mohammed Islam, Sanjana Dixit, Alissa J. Trzeciak, Justin S.A. Perry, Thomas Vierbuchen

H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cells

Emmalee W. Cooke, Cheng Zeng, Suza Mohammad Nur, Yunbo Jia, Aileen Huang, Jiwei Chen, Peidong Gao, Fei Xavier Chen, Fulai Jin, Kaixiang Cao

Immune-Epithelial Interactions via TGF-β Orchestrates Stem-Cell Niche Formation and Morphogenesis

Nicole Traugh, Colin Trepicchio, Gat Rauner, Meadow Parrish, Charlotte Kuperwasser

The biomolecular profiles of extracellular vesicles from odontogenic stem cell lines depict donor-dependent differences and emphasize their therapeutic and regenerative potential

Yong Xu, Alp Sarisoy, Miriam Buhl, Amanda Salviano Silva, Julian Gonzalez Rubio, Anja Lena Thiebes, Sandra Fuest, Ralf Smeets, Franz Lennard Ricklefs, Christian Apel

Commensal skin bacteria interact with the innate immune system to promote tail regeneration in Xenopus laevis tadpoles

Phoebe A. Chapman, Robert C Day, Daniel T. Hudson, Joanna M. Ward, Xochitl C. Morgan, Caroline W. Beck

Isoform-Specific Roles of NTRK2 in Pulmonary Vascular Regeneration

Cheng Tan, Ziyi Liu, Xiangdi Mao, Yunpei Zhang, Xiaolei Li, Nicole Pek, Hailu Fu, Yaping Liu, Vladimir V. Kalinichenko, Gloria S. Pryhuber, Renzhong Lu, Li Lai, Yifei Miao, Minzhe Guo, Mingxia Gu

Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

Ryan A. McCubbin, Mohammad A. Auwal, Shengzhou Wang, Sarai Alvarez Zepeda, Roman Sasik, Robert W. Zeller, Kelly G. Ross, Ricardo M. Zayas

Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury

Binayok Sharma, Xinyue Lu, Hamood Rehman, Vandré C. Figueiredo, Carol Davis, Holly Van Remmen, Shihuan Kuang, Susan V. Brooks, Krishna Rao Maddipati, James F. Markworth

Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish

Miglė Kalvaitytė-Repečkė, Sofija Gabrilavičiūtė, Kotryna Kvederavičiūtė, Leonard Burg, Edita Bakūnaitė, Kenneth D. Poss, Darius Balciunas

Distinct Sox9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids

Nike Walther, Sathvik Anantakrishnan, Gina M. Dailey, Anna C. Maurer, Claudia Cattoglio

Classification of indeterminate and off-target cell types within human kidney organoid differentiation

Sean B. Wilson, Jessica M. Vanslambrouck, Angela Murphy, Drew R. Neavin, Joseph E. Powell, Sara E. Howden, Melissa H. Little

eIF4G2-Mediated Translation Initiation of Histone Modifiers Is Essential for Intestinal Stem Cell Maintenance and Differentiation

Haruko Kunitomi, Aye Myat Khaine, Radia Jamee, Mariselle Lancero, Eugenea Raychaudhuri, Samuel Perli, Yoshiko Sato, Mio Iwasaki, Pedro Ruivo, Kiichiro Tomoda, Mari Mito, Yuichi Shichino, Shintaro Iwasaki, Shinya Yamanaka

CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for cortical neural stem cell maintenance

Jiangli Zheng, Shaojun Qi, Huan Wu, Jun Wu, Guo Chen, Huanhuan Joyce Wang, Han Pan, Ji Li, Cuiqin Cheng, Ke Tang, Lester F. Lau, Qin Shen

Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide

Seda Akgün, Thomas Lenz, Annika Zink, Karina Stephanie Krings, Sebastian Wesselborg, María José Mendiburo, Alessandro Prigione, Kai Stühler, Björn Stork

Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

Ioakeim Ampartzidis, Elliott M Thompson, Yashica Gupta, Andrea Krstevski, Nicola Elvassore, Eirini Maniou, Paolo de Coppi, Gabriel L Galea

Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish

Yi Wang, Thomas Nguyen, Qingan He, Oliver Has, Kiarash Forouzesh, Dae Seok Eom

Tissue resident macrophages innately develop in a human iPSC-derived cardiac organoid model

Anna Frederike Rockel, Tobias Brunnbauer, Nicole Wagner, Brenda Gerull, Sueleyman Erguen, Philipp Woersdoerfer

Bona fide hematopoietic stem cells in zebrafish originate from the supra-intestinal artery

Shachuan Feng, Rui Qu, Yingzhu He, Tingting Huang, Youqi Wang, Thi Huong Trinh, Kefan Cheng, Shizheng Zhao, Ying Huang, Hao Zhu, Sicong He, Zilong Wen

Lineage recording in monoclonal gastruloids reveals heritable modes of early development

Samuel G. Regalado, Chengxiang Qiu, Sanjay Kottapalli, Beth K. Martin, Wei Chen, Hanna Liao, Haedong Kim, Xiaoyi Li, Jean-Benoît Lalanne, Nobuhiko Hamazaki, Silvia Domcke, Junhong Choi, Jay Shendure

Recognition of pathogenic bacteria by intestinal progenitors promotes adult Drosophila midgut regeneration via PGRP-MKK3-p38 signalling

Bhavin Uttekar, Rebecca Wafer, Suci Cendanawati, Parthive H. Patel

Reconstitution of adrenocortical functional zonation from human pluripotent stem cells

Michinori Mayama, Eoin C. Whelan, Takeshi Sato, David G. Stouffer, Adrian N. Leu, Jerome F. Strauss III 3rd, Richard J. Auchus, Kotaro Sasaki

| Plant development

The MpCAFA gene encodes a ciliary protein required for spermatozoid motility in the liverwort Marchantia polymorpha

Mizuki Morita, Katsuyuki T. Yamato

A moss N-Acetyltransferase-MAPK protein controls 2D to 3D developmental transition via acetylation and phosphorylation changes

Cloe de Luxán-Hernández, Thomas J. Ammitsøe, Jakob V. Kanne, Sabrina Stanimirovic, Milena E. Roux, Zoe Weeks, Michael Schutzbier, Gerhard Dürnberger, Elisabeth Roitinger, Liechi Zhang, Oliver Spadiut, Masaki Ishikawa, Mitsuyasu Hasebe, Laura A. Moody, Yasin F. Dagdas, Eleazar Rodriguez, Morten Petersen

Effect of plant tissue culture parameters on the ploidy level of Physalis grisea, Solanum lycopersicum, and Solanum prinophyllum regenerants

Kerry Swartwood, Yumi Green, Iacopo Gentile, Zachary B. Lippman, Joyce Van Eck

VERNALIZATION2 (VRN2) alters early tiller development in a facultative spring hexaploid bread wheat (Triticum aestivum)

Dominique Hirsz, Harry Taylor, India Lacey, Adam Gauley, Laura Dixon

Imputation integrates single-cell and spatial gene expression data to resolve transcriptional networks in barley shoot meristem development

Edgar Demesa-Arevalo, Hannah Dorpholz, Isaia Vardanega, Jan Eric Maika, Itzel Pineda-Valentino, Stella Eggels, Tobias Lautwein, Karl Kohrer, Thorsten Schnurbusch, Maria von Korff, Bjorn Usadel, Rudiger Simon

ROS inhibits microtubule dynamics and cell growth heterogeneity during Arabidopsis sepal morphogenesis

Isabella Burda, Fridtjof Brauns, Aaron Shipman, Emily Shapland, Lilan Hong, Adrienne Roeder

F-53B damages cell viability leading to impaired root development in Arabidopsis

Jiayi Zhao, Wenjing Pan, Yuting Chen, Xueying Cui, Huiqi Fu, Yufeng Luo, Zitong Chen, Nan Huang, Yue Hu, Yonghua Qin, Guanghui Yu, Ziming Ren, Wenyi Wang, Xiaoning Lei, Bing Liu

Too much sugar makes plants ‘pregnant’: maternal sucrose signals fertilization in Arabidopsis seeds

Wenjia Xu, Miryam Iannaccone, Dennys-Marcela Gomez-Paez, Sandrine Choinard, Jing Lu, Rozenn Le Hir, Sylvie Dinant, Lothar Kalmbach, Regina Feil, John E. Lunn, Christian Meyer, Enrico Magnani

The Cell Wall Controls Stem Cell Fate in the Arabidopsis Shoot Apical Meristem

Tasnim Zerin, Paola Ruiz-Duarte, Ann-Kathrin Schürholz, Theresa Schlamp, Yanfei Ma, Carlo Bevilacqua, Nabila El Arbi, Christian Wenzl, Andrej Miotk, Robert Prevedel, Thomas Greb, Jan Lohmann, Sebastian Wolf

Spatial analysis of cell patterning to aid genetic and phenotypic understanding of grass stomatal density: a case study in maize

John G. Hodge, Andrew D.B. Leakey

Stage-resolved gene regulatory network analysis reveals developmental reprogramming and genes with robust stem-preferred expression in sorghum

Jie Fu, Brandon James, Madara Hetti-Arachchilage, Yingjie Lei, Brian McKinley, Evan Kurtz, Kerrie Barry, Stephen P. Moose, John E. Mullet, Kankshita Swaminathan, Amy Marshall-Colon

| Environment, evolution and development

Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

Max S. Farnworth, Yi Peng Toh, Theodora Loupasaki, Elizabeth A. Hodge, Basil el Jundi, Stephen H Montgomery

Developmental landscape of shark telencephalon sheds light on the evolution of telencephalic cell types and the ancient origin of Cajal-Retzius cells

Idoia Quintana-Urzainqui, Phillip A. Oel, Tobias Gerber, Leslie Pan, Nikolaos Papadopoulos, Z. Gülce Serka, Ana Verbanac, Maite Börsig, Dorinda Torres-Sabino, Isabel Clara Rollán-Delgado, Luca Santangeli, Henrik Kaessmann, Detlev Arendt

Predation, evo-devo, and historical contingency: A nematode predator drives evolution of aggregative multicellularity

Kaitlin A. Schaal, Marco La Fortezza, Gregory J. Velicer

Conserved and lineage-restricted gene regulatory programs modulate developmental cnidocyte specification in Nematostella vectensis

Benjamin Danladi, Layla Al-Shaer, Jamie A. Havrilak, Dylan Faltine-Gonzalez, Kejue Jia, Wyatt Forwood, Timothy Dubuc, Jacob Musser, Michael J Layden

Oocyte exposure to low levels of triclosan has a significant impact on subsequent embryo physiology

Vasiliki Papachristofi, Paul McKeegan, Henry J Leese, Jeanette M. Rotchell, Roger Sturmey

Rhythms of early life: gut microbiota rhythmicity and circadian maturation in infants

Christophe Mühlematter, Dennis S. Nielsen, Josue L. Castro-Mejía, Jean-Claude Walser, Sarah F. Schoch, Salome Kurth

A Notch signal required for a morphological novelty in Drosophila has antecedent functions in genital disc eversion

Donya N. Shodja, William J. Glassford, Gavin Rice, Sarah J. Smith, Mark Rebeiz

African Cichlid Lake Radiations Recapitulate Riverine Axial Morphologies Through Repeated Exploration of Morphospace

Callum V. Bucklow, Emanuell Duarte Ribeiro, Fabrizia Ronco, Nathan Vranken, Michael K. Oliver, Walter Salzburger, Melanie Stiassny, Roger Benson, Berta Verd

Parallels in the Regulatory Landscape of Dimorphic Female and Male Genital Structures in Drosophila melanogaster

Eden McQueen, Gavin Rice, Shanker Pillai, Omid Saleh Ziabari, Ben J Vincent, Mark Rebeiz

Cellular and Immune Adaptations at the Maternal–Fetal Interface in Bats

Allyson Caldwell, Liheng Yang, Rebecca L. Casazza, Rizban E. Worota, Cole McCutcheon, Patrick S. Creisher, Erika Zhan, Clara Reasoner, Ashley Higgins, Tony Schountz, Carolyn B. Coyne

Divergent paths, convergent heads: morphological adaptation of head shape to ecological niches in snakes

David Hudry, Anthony Herrel

A novel Hox gene promoter fuels the evolution of adaptive phenotypic plasticity

Shen Tian, Bonnie Lee, Tirtha Das Banerjee, Suriya Narayanan Murugesan, Antónia Monteiro

A Developmental Mechanism Linking Heart Evolution and Congenital Defects

Nina Kraus, Fabian Placzek, Rostyslav Samonov, Quang Nguyen, Brian Metscher

Defective splicing of Y-chromosome-linked gigantic genes underlies hybrid male sterility in Drosophila

Adrienne Fontan, Romain Lannes, Jaclyn M. Fingerhut, Jullien M. Flynn, Yukiko M. Yamashita

Pre-dauer starvation decouples somatic from germline development with lifelong reproductive consequences in C. elegans

Fred A. Koitz, Camille P. Miller, Kacy Lynn Gordon

Somitic Change Drives Changes in Vertebral Regionalisation in African Cichlids Despite Strong Canalisation of Somite Number

Callum V Bucklow, Emanuell Duarte Ribeiro, Roger Benson, Berta Verd

Multi-stage single-cell atlas of Botryllus schlosseri asexual development unveils dedifferentiating bud founder cells

Marie Lebel, Tiphaine Sancerini, Sharon Rabiteau, Solène Marchal, Pragati Sharma, Tal D. Scully, Estelle Balissat, Laurel S. Hiebert, Anthony W. De Tomaso, Allon M. Klein, Alexandre Alié, Stefano Tiozzo

Structural innovations and neurogenic continuity define avian brain development and evolution

Hongcheng Shan, Yan Mei, Zhenhuan Feng, Xilin Gu, Liu Huang, Yuan Hui, Chunqiong Li, Yingying Zhou, Junjie He, Ran Wu, Zhengkun Zhuang, Mengzhu Wang, Duoyuan Chen, Yongjie Wu, Li Zhang, Guangshuai Jia

Cell Biology

Proteomic profiling of primary cilia in the developing brain uncovers new regulators of cortical development

Xiaoliang Liu, Oscar Torres Gutierrez, Gurleen Kaur, Yazan Al-Issa, Sabyasachi Baboo, Jolene K. Diedrich, Eva Cai, John R. Yates III, Xuecai Ge

Balanced DNA-to-Cytoplasm Ratio at the 2-Cell Stage Is Critical for Mouse Preimplantation Development

Tao Pan, Natsumi Taira, Miho Ohsugi

Vitrification-warming delays preimplantation development and impairs mitochondrial function and cytoplasmic lattices integrity in mouse embryos

Mariana T. Barroso, Jose A. Rodríguez Muñoz, Viola Sjöström, Konstantina Dindini, Jian Zhao, Kenny A. Rodriguez-Wallberg, Arturo Reyes-Palomares

Ontogeny of the vagal gut-brain axis

Kendall J. Lough, Jackson C. Knox, Sheryl S. Moy, Juliet S. King, Scott E. Williams

METTL9 sustains vertebrate neural development primarily via non-catalytic functions

Azzurra Codino, Luca Spagnoletti, Claudia Olobardi, Alessandro Cuomo, Helena Santos-Rosa, Martina Palomba, Natasha Margaroli, Stefania Girotto, Rita Scarpelli, Shi-Lu Luan, Eleonora Crocco, Paolo Bianchini, Andrew J. Bannister, Stefano Gustincich, Tony Kouzarides, Riccardo Rizzo, Isaia Barbieri, Federico Cremisi, Robert Vignali, Luca Pandolfini

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Patrizia Pessina, Mika Nevo, Junchao Shi, Srikanth Kodali, Eduard Casas, Yingzhi Cui, Alicia L. Richards, Emily J. Park, Xi Chen, Florencia Levin-Ferreyra, Erica Stevenson, Nevan J. Krogan, Danielle L. Swaney, Qilong Ying, Qi Chen, Justin Brumbaugh, Bruno Di Stefano

The proteostatic landscape of healthy human oocytes

Gabriele Zaffagnini, Miquel Solé, Juan Manuel Duran, Nikolaos P. Polyzos, Elvan Böke

The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during Drosophila oogenesis

Jonathon M. Thomalla, Michelle S. Giedt, Roger P. White, Israel J. Wipf, Alicia Shipley, Michael A. Welte, Tina L. Tootle

Basal autophagy during meiotic prophase I is required for accurate chromosome segregation in Drosophila oocytes and declines during oocyte aging

Diana C. Hilpert, Muhammad Abdul Haseeb, Sharon E. Bickel

Generation and maintenance of apical rib-like actin fibers in epithelial support cells of the Drosophila eye

Abhi Bhattarai, Emily W McGhie, Joshua C Woo, Srijana Niraula, Patrick Rosetti, Jaxon M Kim, Ezekiel Popoola, Ruth I Johnson

Genetic ablation of Pth4 disrupts calcium-phosphate balance, bone development, and kidney transcriptome in teleosts

Luis Méndez-Martínez, Paula Suarez-Bregua, Laura Guerrero-Peña, Elisa Barreiro-Docío, Carolina Costas-Prado, Antonio Cobelo-García, Josep Rotllant

Inorganic profiles of preimplantation embryos reveal a role for zinc in blastocyst development

Julia L. Balough, Thomas V. O’Halloran, Francesca E. Duncan, Teresa K. Woodruff

Embryonic Stem Cell-Specific Responses to DNA Replication Stress

Ryan C. James, Jerry K. Wang, Siddhanth R. Bhatt, Sophie E. Shadid, Daryl J. Phuong, John C. Schimenti

Identification of locally activated spindle-associated proteins in oocytes uncovers a phosphatase-driven mechanism

Xiang Wan, Hiroyuki Ohkura

Integration of past caspase activity biases cell elimination in vivo

Tom Cumming, Alexis Villars, Anđela Davidović, Florence Levillayer, Léo Valon, Romain Levayer

Beyond the Axoneme: Whole-Cell Proteomics Identifies Novel Regulators of Ciliogenesis in Xenopus Epidermal Multiciliated Cells

Xiaolu Xu, Yanbao Yu, Tony Zheng, Fiona Clark, Jean Ross, Andre L P Tavares, Shuo Wei, Jian Sun

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne

Lineage Analysis and Molecular Characterization of Bergmann Glia-like Progenitors in the Postnatal Mouse Cerebellum using in vivo Electroporation and Spatial Transcriptomics

Kyoka Suyama, Toma Adachi, Eriko Isogai, Ikuko Hasegawa, Minami Mizuno, Ji Kaiyuan, Kayo Nishitani, Satoshi Miyashita, Tomoo Owa, Mikio Hoshino

The RNA splicing factor PRPF8 is required for left-right organiser cilia function and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

Fangfei Jiang, Michael Boylan, Dale W. Maxwell, Wasay Mohiuddin Shaikh Qureshi, Charlie F. Rowlands, Gennadiy Tenin, Karen Mitchell, Louise A. Stephen, Elton J. R. Vasconcelos, Dapeng Wang, Tong Chen, Junzhe Zha, Jingshu Liu, Nouf Althali, Dragos V. Leordean, Meurig T. Gallagher, Basudha Basu, Katarzyna Szymanska, Advait Veeraghanta, Bernard Keavney, Martin J. Humphries, Jamie Ellingford, David Smith, Colin A. Johnson, Raymond T. O’Keefe, Sudipto Roy, Kathryn E. Hentges

AID-mediated protein knockdown reveals the requirement of NANOS2 in prenatal gonocytes for establishing functional spermatogonial stem cells

Yumiko Saga, Quan Wu

LMO2 regulates epithelial-mesenchymal plasticity of mammary epithelial cells

Veronica Haro-Acosta, Maria A. Juarez, Isobel J. Fetter, Andrew Olander, Shaheen S. Sikandar

miR-190 is a Key Regulator in Establishing Cell Polarity and Specification in the Drosophila Nervous System

Gerson Ascencio, Laura Galvan, Julie M. Sanchez, Ariana Nagainis, Cynnie Tam, Lauren M. Goins, Blake Riggs

Modelling

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos

Xin Li, Robert J. Huebner, Margot L.K. Williams, Jessica Sawyer, Mark Peifer, John B. Wallingford, D. Thirumalai

Fundamental limits on patterning by Turing-like reaction-diffusion mechanisms

Daniel Muzatko, Bijoy Daga, Tom W. Hiscock

Start Small: A Model for Tissue-wide Planar Cell Polarity without Morphogens

Abhisha Thayambath, Julio M Belmonte

Tools & Resources

Open RGB Imaging Workflow for Morphological and Morphometric Analysis of Fruits using AI: A Case Study on Almonds

Mas-Gómez Jorge, Rubio Manuel, Dicenta Federico, Martínez-García Pedro José

Parsing glomerular and tubular structure variability in high-throughput kidney organoid culture

Kristiina Uusi-Rauva, Anniina Pirttiniemi, Antti Hassinen, Ras Trokovic, Sanna Lehtonen, Jukka Kallijärvi, Markku Lehto, Vineta Fellman, Per-Henrik Groop

Heart spheroids from primary cells for studying cardiac development

Cindy Chang, Juan Xu, Shirley Chang, Guang Li

In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.

Atesh Kara Worthington, Beltran Borges, Tony Lum, Elisa Schrader Echeverri, Fareha Moulana Zada, Marco Cordero, Hyejin Kim, Ryan Zenhausern, Ozgenur Celik, Cindy Shaw, Paula Gutierrez-Martinez, Marzhana Omarova, Chris Blanchard, Sean Burns, Kyle Cromer, James Dahlman, Tippi MacKenzie

Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system

Baochen Bai, Jiting Li, Ze Wang, Yuhan Yang, Jieqing He, Gonglie Chen, Yufan Zhang, Yan Qi, Zhongjun Wan, Lin Cai, Run Wang, Kai Wang, Dongyu Zhao, Jingzhong Zhang, Weihua Huang, Ronald X Xu, Mingzhai Sun, Xiao Han, Yan Liu, Donghui Zhang, Wanying Zhu, Jian Liu, Yuxuan Guo

An efficient protocol to derive primordial germ cell like cells in vitro from murine embryonic stem cells

Umesh Kumar, Nithyapriya Kumar, P Chandra Sekhar, Kumarasamy Thangaraj

Hematopoietic Single Cell Atlas Reveals a Diverse Repertoire of Lymphoid Cells in Larval Zebrafish

Anastasia Nizhnik, Bianca A. Ulloa, Kevyn Jackson, Deyou Zheng, Teresa V. Bowman

A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species

Duo Wang, Hao Ming, Dongshan Yang, Li-Kuang Tsai, Zhuying Wei, Giovanna Nascimento Scatolin, Xiukun Wang, Kimberly Yau, Litao Tao, Xinyi Tong, Shuling Wang, Kai-Xuan Shi, Denis Evseenko, Ben Van Handel, Bingjing Zhang, Yinjuan Wang, Rajan Iyyappan, Oscar Alejandro Ojeda-Rojas, Guang Hu, Lynda McGinnis, Richard Paulson, Daniel Mckim, Xiangbo Kong, Xiaofeng Xia, Jifeng Zhang, Y. Eugene Chen, Jie Xu, Zongliang Jiang, Qi-Long Ying

Enrichment of neural crest cells by antibody labelling and flow cytometry for single-cell transcriptomics in a lizard

Robin Pranter, Cedric Patthey, Nathalie Feiner

A cell and transcriptome atlas of the human arterial vasculature reveals roles of developmental master regulators in health and disease

Quanyi Zhao, Albert Pedroza, Disha Sharma, Wenduo Gu, Alex Dalal, Chad Weldy, William Jackson, Daniel Yuhang Li, Yana Ryan, Trieu Nguyen, Rohan Shad, Brian T. Palmisano, João P. Monteiro, Matthew Worssam, Alexa Berezwitz, Meghana Iyer, Huitong Shi, Ramendra Kundu, Lasemahang Limbu, Juyong Brian Kim, Anshul Kundaje, Michael Fischbein, Robert Wirka, Thomas Quertermous, Paul Cheng

Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesis

Kaisa Pakari, Sevinç Jakab, Encarnación Sánchez Salvador, Christian Thiel, Joachim Wittbrodt, Thomas Thumberger

Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens

Samuel G. Regalado, Chengxiang Qiu, Jean-Benoît Lalanne, Beth K. Martin, Madeleine Duran, Cole Trapnell, Aidan Keith, Silvia Domcke, Jay Shendure

Efficient installation of heterozygous mutations in human pluripotent stem cells using prime editing

Annabelle Suter, Alison Graham, Jia Yi Kuah, Jason Crisologo, Chathuni Gunatilake, Koula Sourris, Michael See, Fernando J Rossello, Mirana Ramialison, Katerina Vlahos, Sara E Howden

CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages

Gabriel Garnik Hovhannisyan, Tawba Akhourbi, Sema Elif Eski, Isabelle Pirson, Esteban N. Gurzov, Sumeet Pal Singh

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data

Marine Fontaine, M. Joaquina Delas, Meritxell Saez, Rory J. Maizels, Elizabeth Finnie, James Briscoe, David A. Rand

Establishment of Drosophila Intestinal Cell Lines

Arthur Luhur, Daniel Mariyappa, Peter Bohall, Laura Multini, Morgan Elkins, Andrew C. Zelhof

Research practice & education

The SAFE Labs Handbook: community-driven commitments for group leaders to improve lab culture

E Donà, JM Gahan, P Lau, J Jeschke, T Ott, K Reinhard, C Sinigaglia, JL Treur, T Vogl, S Bugeon, L Mariotti, LF Rossi, P Coen

The evolution of interdisciplinarity and internationalization in scientific journals

Huaxia Zhou, Luís A. Nunes Amaral

Gaming the Metrics? Bibliometric Anomalies and the Integrity Crisis in Global University Rankings

Lokman I. Meho

(No Ratings Yet)
Loading...