Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Evo-devo

Cell Biology

Modelling

Tools & Resources

Developmental biology

| Patterning & signalling

Synchronization of the segmentation clock using synthetic cell-cell signaling

Akihiro Isomura, Daisuke Asanuma, Ryoichiro Kageyama

Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

Odessa R. Yabut, Hector Gomez, Jessica Arela, Jesse Garcia Castillo, Thomas Ngo, Samuel J. Pleasure

Self-organization of spermatogenic wave coordinates sustained sperm production in the mouse testis

Toshiyuki Sato, Yuting I. Li, David J. Jörg, Mitsuru Komeya, Hiroyuki Yamanaka, Hiroko Nakamura, Kodai Hirano, Yohei Kondo, Kazuhiro Aoki, Masahide Takahashi, Hiroki Nakata, Hiroshi Kimura, Takehiko Ogawa, Benjamin D. Simons, Shosei Yoshida

Spatiotemporally restricted Hippo signalings instruct the fate and maturation of hepatobiliary cells

Yebin Wang, Zhenxing Zhong, Yu Wang, Ying Zhu, Kun-Liang Guan, Fa-Xing Yu

Construction of an embryonic caudal organizer by BMP4

Yan-Yi Xing, Ying Huang, Tao Cheng, Tao Luo, Yang Dong, Zi-Xin Jin, Yi-Meng Tian, Xiang Liu, Jun Ma, Jun-Feng Ji, Peng-Fei Xu

Bone Morphogenetic Protein signaling pathway – ethanol interactions disrupt palate formation independent of gata3

C. Ben Lovely

A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects

Henrike Berns, Maximilian Haas, Zeineb Bakey, Magdalena Maria Brislinger-Engelhardt, Miriam Schmidts, Peter Walentek

Calcium signalling is required for anterior patterning in the mouse embryo

Matthew J. Stower, Richard C. V. Tyser, Shifaan Thowfeequ, Felix Zhou, Marta Portela, Konstantinos Miti, Jacintha Sugnaseelan, Xin Lu, Shankar Srinivas

Spatiotemporal transcriptomic analyses reveal molecular gradient patterning during development and the tonotopic organization along the cochlear axis

Mengzhen Yan, Penghui Zhang, Yafan Wang, Haojie Wang, Junhong Li, Xiang Guo, Xiangyao Zeng, Zhili Feng, Yushan Gao, Fei Deng, Bicheng Zhu, Di Deng, Lu Ma, Yong Feng, Hua-Jun Wu, Yu Zhao, Jun Li

Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription

Virginia L Pimmett, James McGehee, Antonio Trullo, Maria Douaihy, Ovidiu Radulescu, Angelike Stathopoulos, Mounia Lagha

Timing of delamination of inner ear neurons specifies their topography and target innervation

Surjit Singh Saini, Raj K. Ladher

Developmental functions of rapgef1b in neural crest specification and presomitic mesoderm patterning

Tuhina Prasad, Sharada Iyer, Sian D’silva, Reuben J. Mathew, Divya Tej Sowpati, Vegesna Radha, Megha Kumar

Self-organized patterning of peristaltic waves by suppressive actions in a developing gut

Koji Kawamura, Soichiro Kato, Shota Utsunomiya, Yoshiko Takahashi, Masafumi Inaba

Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish

Delai Huang, Emaan Kapadia, Yipeng Liang, Leah P. Shriver, Shengkun Dai, Gary J. Patti, Bruno M. Humbel, Vincent Laudet, David M. Parichy

| Morphogenesis & mechanics

Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors

Olivia Powell, Emily Garcia, Vanshika Sriram, Yi Qu, Nandan L. Nerurkar

Heart tube morphogenesis is regulated by segment-specific gene regulatory networks controlled by MEF2C

Jonathon M. Muncie-Vasic, Tanvi Sinha, Alexander P. Clark, Emily F. Brower, Jeffrey J. Saucerman, Brian L. Black, Benoit G. Bruneau

Multi-modal characterization of rodent tooth development

Yuchen Jiang, Kaitlin A. Katsura, Nir Z. Badt, Marius Didziokas, Sonia Dougherty, David L. Goldsby, Elizabeth J. Bhoj, Kyle Vining

Calcium transients regulate epithelial integration of multiciliated cells during Xenopus skin development

Neophytos Christodoulou, Paris A. Skourides

Vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation in the heart

Xiaofei Li, Rainy Wortelboer, Yi Song, Sahana Balasubramanian, Callie McLain, Alex Hernandez Manriquez, Joseph Suh, Brenton D. Hoffman, Adam V. Kwiatkowski, Glenn L. Radice

TiFM2.0 – Versatile mechanical measurement and actuation in live embryos

Ana R. Hernandez-Rodriguez, Yisha Lan, Fengtong Ji, Susannah B.P. McLaren, Joana M. N. Vidigueira, Ruoheng Li, Yixin Dai, Emily Holmes, Lauren D. Moon, Lakshmi Balasubramaniam, Fengzhu Xiong

Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish

Oguzhan F Baltaci, Andrea Usseglio Gaudi, Stefanie Dudczig, Weili Wang, Maria Cristina Rondon-Galeano, Ye-Wheen Lim, James Rae, Anne Lagendijk, Robert G Parton, Alison Farley, Benjamin M Hogan

Local weakening of cell-ECM adhesion triggers basal tissue folding via changes in cell shape, actomyosin organization and E-cad levels

Andrea Valencia-Exposito, Nargess Khalilgharibi, Ana Martinez Abarca Millan, Yanlan Mao, Maria Dolores Martin-Bermudo

Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen

A. Serrano, C. Puerner, E. Plumb, L. Chevalier, J. Elferich, L.R. Sinn, N. Grigorieff, M. Ralser, M. Delarue, M. Bassilana, R.A. Arkowitz

Timely neurogenesis enables increased nuclear packing order during neuronal lamination

Lucrezia C. Ferme, Allyson Q. Ryan, Robert Haase, Carl D. Modes, Caren Norden

Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere

Yuzhao Song, Paloma Martín, Tianhui Sun, Ernesto Sánchez-Herrero, José Carlos Pastor-Pareja

Organization of the apical extracellular matrix during tubular organ formation

J. Luke Woodward, Jeffrey Matthew, Vishakha Vishwakarma, Ying Xiao, SeYeon Chung

| Genes & genomes

Spatiotemporal regulation by downstream genes of Prok2 in olfactory system: from development to function

Bo-Ra Kim, Min-Seok Rha, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Kim

RNA Binding Protein Khdrbs1 Regulates Hematopoietic Stem and Progenitor Cell Emergence via Splicing

Ilana Karp, Teresa V. Bowman

Maternal Med12 safeguards trophoblast pluripotency and placental development

Michelle M. Halstead, Jyoti Goad, Amina Khan, Rutuja Deshmukh, Aleksandar Rajkovic

Drosophila melanogaster employs nuclear architecture for recruitment of dosage compensation

Maggie P. Lauria Sneideman, Victoria H. Meller

Conversion of somatic sex identity in the testis induces female-specific cellular behaviors in the soma and early oocyte specification in the germline

Tiffany V. Roach, Sneh Harsh, Rajiv Sainath, Erika A. Bach, Kari F. Lenhart

Investigating a possible role of R3HCC1L in embryonic development and ocular disease

Megan C. Fischer, Linda M. Reis, Sanaa Muheisen, Sarah E. Seese, Elena V. Semina

AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation

Cecilia S. Blengini, Robert J. Mendola, G. John Garrisi, Jason E. Swain, Karen Schindler

Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms

Sarah Bowden, Magdalena Maria Brislinger-Engelhardt, Mona Hansen, Africa Temporal-Plo, Damian Weber, Sandra Hägele, Fabian Lorenz, Tim Litwin, Clemens Kreutz, Peter Walentek

Epidermal loss of PRMT5 leads to the emergence of an atypical basal keratinocyte-like cell population and defective skin stratification

Nicole M Recka, Andrean Simons, Robert A Cornell, Eric Van Otterloo

Drospondin, a novel glial-secreted glycoprotein, controls the development and function of the Drosophila nervous system

Francisca Rojo-Cortés, Candy Roa-Siegfried, Nicolás Fuenzalida-Uribe, Paula Amado-Hinojosa, María-Constanza González-Ramírez, Isidora Almonacid-Torres, Serge Birman, Lindsey D Goodman, Oguz Kanka, Carlos Oliva, María-Paz Marzolo, Jorge M Campusano

Combined SNP parental haplotyping and intensity analysis identifies meiotic and mitotic aneuploidies and frequent segmental aneuploidies in preimplantation human embryos

Alan H Handyside, Louise Newnham, Matthew Newnham, Dominika Henning, Jan Velebny, Jan Pozdena, Jindriska Krmelova, Jakub Horak

TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation

Esteban M Dominguez, Ayelen M Moreno Irusta, Regan L Scott, Khursheed Iqbal, Michael Soares

Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells

Toshihiro Kawasaki, Toshiya Nishimura, Naoki Tani, Carina Ramos, Emil Karaulanov, Minori Shinya, Kenji Saito, Emily Taylor, Rene F. Ketting, Kei-ichiro Ishiguro, Minoru Tanaka, Kellee R. Siegfried, Noriyoshi Sakai

A PRDM16-CtBP1/2 Complex Interacts with HDAC1/2 to Regulate Transcriptional Programs of Neurogenesis and Guide Cortical Neuron Migration

Sophie Warren, Bader El Farran, Sungyun Kang, Adhyeta Choudhuri, Sen Xiong, Volker P. Brendel, Manuel Baizabal

Ribosome abundance, not paralogue composition, is essential for germline development

Katarina Z A Grobicki, Daniel Gebert, Carol Sun, Felipe Karam Teixeira

Novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4

Sayo Tozawa, Haruka Matsubara, Fumina Minamitani, Yasuhiro Kamei, Misako Saida, Momoko Asao, Ken-ichi T. Suzuki, Masatoshi Matsunami, Shuji Shigenobu, Toshinori Hayashi, Gembu Abe, Takashi Takeuchi

Sox9 and Nfi transcription factors regulate the timing of neurogenesis and ependymal maturation in dopamine progenitors

Laura Lahti, Nikolaos Volakakis, Linda Gillberg, Behzad Yaghmaeian Salmani, Katarína Tiklová, Nigel Kee, Hilda Lundén-Miguel, Michael Piper, Richard Gronostajski, Thomas Perlmann

Mutations in the microexon splicing regulator srrm4 have minor phenotypic effects on zebrafish neural development

Tripti Gupta, Gennady Margolin, Harold A. Burgess

Single cell RNA-sequencing reveals no evidence for meiotic sex chromosome inactivation in the threespine stickleback fish

Daniel E. Shaw, Wynter D. Ross, Alexis V. Lambert, Michael A. White

Developmental DNA Methylation in the Parasitoid Wasp Nasonia vitripennis

CL Thomas, EB Mallon

p300/CBP-catalyzed acetylation safeguards minor zygotic genome activation via activating DUX

Lieying Xiao, Hao Jin, Yanna Dang, Panpan Zhao, Shuang Li, Yan Shi, Shaohua Wang, Kun Zhang

Ribosome abundance, not paralogue composition, is essential for germline development

Katarina Z A Grobicki, Daniel Gebert, Carol Sun, Felipe Karam Teixeira

Transcriptional Regulation of Mammary Alveolar Proliferation and Differentiation during Early Pregnancy

John Vusich, Jesus Garcia-Lerena, Anthony Schulte, Ryan Corfixsen, Eran Andrechek

Analysis of a hypomorphic mei-P26 mutation reveals developmental control of CO patterning mechanisms

Erica Berent, Ally Solomon, Amanda P. Spencer, Oscar Bautista, Joe Terry, Elizabeth T. Ables, Nicole Crown

The Integrator complex prevents premature neuronal differentiation through global control of transcription elongation

Hedda B. Somsen, Kristel N. Eigenhuis, Anne L. Kuijpers-Korporaal, Mariana Pelicano de Almeida, Roberto Montoro Ferrer, Kelsey Kats, Mike R. Dekker, Thuur Zuidweg, Zakia Azmani, Mirjam C.G.N. van den Hout, Wilfred F.J. van IJcken, Danny Huylebroeck, Maarten Fornerod, Raymond A. Poot, Debbie L.C. van den Berg

Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo

Daniel M. Snell, Wazeer Varsally, Aurélien Courtois, Sergio Menchero, Prabhakaran Munusamy, Richelle Rietdijk, Obah A. Ojarikre, Stephanie Strohbuecker, Haskan Kaya, Mahesh N. Sangrithi, James M.A. Turner

Multi-level transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal element sex-1

Eshna Jash, Zoey M. Tan, Audry I. Rakozy, Anati Alyaa Azhar, Hector Mendoza, Györgyi Csankovszki

The transcription factor GABPA is a master regulator of naïve pluripotency

Chengjie Zhou, Meng Wang, Chunxia Zhang, Yi Zhang

| Stem cells, regeneration & disease modelling

Tenascin-C from the tissue microenvironment promotes muscle stem cell self-renewal through Annexin A2

Mafalda Loreti, Alessandra Cecchini, Collin D. Kaufman, Cedomir Stamenkovic, Alma Renero, Chiara Nicoletti, Anais Kervadec, Gabriele Guarnaccia, Daphne Mayer, Alexandre Colas, Pier Lorenzo Puri, Alessandra Sacco

Altered renal vascular patterning reduces ischemic kidney injury and limits vascular loss associated with aging

Sarah R. McLarnon, Samuel E. Honeycutt, Pierre-Emmanuel Y. N’Guetta, Yubin Xiong, Xinwei Li, Koki Abe, Hiroki Kitai, Tomokazu Souma, Lori L. O’Brien

From McLarnon et al. This image is made available under a CC-BY-NC 4.0 International license.

Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects

Chien-Hui Lo, Siyu Chen, Jingyu Zhao, Zhiquan Liu, Biao Wang, Qing Wang, Tia J. Kowal, Yang Sun

Identification of molecular and functional subtypes using chronic pancreatitis patient-derived organoid models

Victoria Osorio-Vasquez, Jan C. Lumibao, Kristina L. Peck, Kathryn Lande, Jonathan Zhu, McKenna Stamp, Shira R. Okhovat, Hyemin Song, Satoshi Ogawa, Jasper Hsu, Yang Dai, Angelica Rock, Chelsea Bottomley, Ethan Thomas, Alexandra Fowler, T’Onj McGriff, Siri Larsen, Muhamad Abdulla, Phil Greer, Jessica Gibson, Michael Downes, Ronald Evans, Jingjing Zou, Andrew M. Lowy, David C. Whitcomb, Rebekah White, Melena Bellin, Herve Tiriac, Dannielle D. Engle

Secretome analysis of human and rat pancreatic islets co-cultured with adipose-derived stromal cells reveals a signature with enhanced regenerative capacities

Erika Pinheiro-Machado, Bart J. de Haan, Marten A. Engelse, Alexandra M. Smink

Non-gonadal PIWI protein, Aubergine, regulates regenerative stem cell proliferation and tumourigenesis in the Drosophila adult intestine

Karen Bellec, Lynsey R Carroll, Kathryn AF Pennel, Yuanliangzi Tian, Yachuan Yu, Alexander R Cameron, Fabiana Herédia, Alisson M Gontijo, Joanne Edwards, Rippei Hayashi, Julia B Cordero

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J Clark, Marius Ueffing

Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

Mengjie Li, Aiguo Tian, Jin Jiang

Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis

Nedaa Al_Jezani, Asmaa Affan, Catherine Leonard, Nabangshu Das, Luiz Gustavo Almeida, Daniel Young, Anand O Masson, Antoine Dufour, Paul Salo, Pam Railton, James N Powell, Roman J Krawetz

Ovarian germline stem cell dedifferentiation is cytoneme-dependent

Catherine Sutcliffe, Nabarun Nandy, Hilary L Ashe, Scott G Wilcockson

HUMAN SPINAL CORD ORGANOIDS REVEAL CELL INTERCALATION AS A CONSERVED MECHANISM FOR SECONDARY NEURULATION

Jose Blanco-Ameijeiras, Mar Garcia-Valero, Yara El Majzoub, Elena Rebollo, Javier Macho-Rendon, Jorge Corbacho, Juan Ramon Martinez-Morales, Elisa Marti

A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration

John W. Quinn, Mariah C. Lee, Chloe Van Hazel, Melissa A. Wilson, Robin E. Harris

Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism

Haopeng Lin, Deqi Chen, Feng Zhang, Xin Liu, Xiaoxiao Xie, Qifei Dong, Jiawei Yan, Jiaxiang Yin, Zirong Bi, Kuo Jiang, Tongran Zhang, Peng Xue, Wei Peng, Lihua Chen, Tao Xu, Yanying Guo, Zonghong Li, Huisheng Liu

Chromosomal Instability in Human Trophoblast Stem Cells and Placentas

Danyang Wang, Andrew Cearlock, Katherine Lane, Ian Jan, Rajiv McCoy, Min Yang

Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration

Victor M. Lewis, Rafael A. Fernandez, Samuel G. Horst, Kryn Stankunas

Primed bovine embryonic stem cell lines can be derived at diverse stages of blastocyst development with similar efficiency and molecular characteristics

Carly Guiltinan, Ramon C. Botigelli, Juliana I. Candelaria, Justin M. Smith, Rachel B. Arcanjo, Anna C. Denicol

A Cardiac Transcriptional Enhancer is Repurposed During Regeneration to Activate an Anti-proliferative Program

Anupama Rao, Andrew Russell, Jose Segura-Bermudez, Charles Franz, Rejenae Dockery, Anton Blatnik, Jacob Panten, Mateo Zevallos, Carson McNulty, Maciej Pietrzak, Joseph Aaron Goldman

Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool

Dorsa Toghani, Sanika Gupte, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani, Christian Burns, David Gravano, Stefan Radtke, Hans-Peter Kiem, Sonia Rodriguez, Nadia Carlesso, Amogh Pradeep, Alexis Georgiades, Fabienne Lucas, Nicola K. Wilson, Sarah J. Kinston, Berthold Göttgens, Le Zong, Isabel Beerman, Bongsoo Park, Derek Janssens, Daniel Jones, Ali Toghani, Claus Nerlov, Eric Pietras, Marion Mesnieres, Christa Maes, Atsushi Kumanogoh, Thomas Worzfeld, Jin-Gyu Cheong, Steven Z Josefowicz, Peter Kharchenko, David T. Scadden, Antonio Scialdone, Joel A Spencer, Lev Silberstein

CD90 identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance

Eyemen Kheir, Michela Libergoli, Samuele Metti, Jonas Brorson Jensen, Jakob Wang, Niels Jessen, Francesca Florio, Francesca Murganti, Serena Di Savino, Marzia Belicchi, Chiara Villa, Kristian Vissing, Mayank Verma, Lorenzo Giordani, Paolo Bonaldo, Yvan Torrente, Jean Farup, Stefano Biressi

Hypoxia inhibits newt skeletal muscle dedifferentiation

Georgii Vdovin, Hannah E. Walters, Konstantin E. Troyanovskiy, Yugo Tsuchiya, Maximina H Yun

Immortalized Intestinal Telocytes – A Stem Cell Niche In Vitro

Marco Canella, Amal Gharbi, Deborah Duran, Yinon Ben-Neriah, Liron Birimberg-Schwartz, Ittai Ben-Porath, Myriam Grunewald, Michal Shoshkes-Carmel

Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor cells

Davide Cinat, Rufina Maturi, Jeremy P. Gunawan, Anne L Jellema-de Bruin, Laura Kracht, Paola Serrano Martinez, Yi Wu, Abel Soto-Gamez, Marc-Jan van Goethem, Inge R. Holtman, Sarah Pringle, Lara Barazzuol, Rob P. Coppes

Non-viral derivation of induced pluripotent stem cells from the canine umbilical cord

Atsushi Yamazaki, Seiji Shiozawa, Yuko Koushige, Hirotaka Kondo, Hisashi Shibuya, Kazuya Edamura

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice

Soomin Cho, Emilia Servián-Morilla, Victoria Navarro Garrido, Beatriz Rodriguez-Gonzalez, Youxi Yuan, Raquel Cano, Arjun A. Rambhiya, Radbod Darabi, Robert S. Haltiwanger, Carmen Paradas, Hamed Jafar-Nejad

Annelid perspectives into the role of FGF signaling in caudal regeneration

Alexandra Y. Shalaeva, Vitaly V. Kozin

Cardiac electrical abnormalities in a mouse model of left ventricular non-compaction cardiomyopathy

Vítor S. Fernandes, Ricardo Caballero, Marcos Siguero-Álvarez, Tania Papoutsi, Juan Ramón Gimeno, Eva Delpón, José Luís de la Pompa

Transcriptional Regulatory Logic Orchestrating Lymphoid and Myeloid Cell Fate Decisions

Rasoul Godini, Michaël Chopin

Quiescent neural stem cells transiently become ‘neurons’ to coordinate reactivation

Laura-Yvonne Gherghina, Jocelyn L.Y. Tang, Andrea H. Brand

| Plant development

Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense

Wen-Hao Han, Feng-Bin Zhang, Shun-Xia Ji, Kai-Lu Liang, Jun-Xia Wang, Xiao-Ping Fan, Shu-Sheng Liu, Xiao-Wei Wang

Complex sphingolipids are essential for cell division and plasmodesmal development in the moss Physcomitrium patens

Linus Wegner, Cornelia Herrfurth, Ivo Feussner, Katrin Ehlers, Tegan M. Haslam

Antagonizing cis-regulatory elements of a conserved flowering gene mediate developmental robustness

Amy Lanctot, Anat Hendelman, Peter Udilovich, Gina M. Robitaille, Zachary B. Lippman

The 5-methylcytosine DNA glycosylase ROS1 antagonizes parent-of-origin specific DNA methylation in Arabidopsis endosperm

Elizabeth A. Hemenway, Mary Gehring

SeedMatExplorer: The transcriptome atlas of Arabidopsis seed maturation

Mariana A. S. Artur, Robert A. Koetsier, Leo A. J. Willems, Lars L. Bakermans, Annabel D. van Driel, Joram A. Dongus, Bas J. W. Dekkers, Alexandre C. S. S. Marques, Asif Ahmed Sami, Harm Nijveen, Leónie Bentsink, Henk Hilhorst, Renake Nogueira Teixeira

Tomato roots exhibit distinct, development-specific responses to bacterial-derived peptides

Rebecca Leuschen-Kohl, Robyn Roberts, Danielle M. Stevens, Ning Zhang, Silas Buchanan, Brooke Pilkey, Gitta Coaker, Anjali S. Iyer-Pascuzzi

PATROL1-mediated H+-ATPase translocation boosts plant growth under drought by optimizing root and leaf functions

Naoya Katsuhama, Kazuma Sakoda, Haruki Kimura, Yutaro Shimizu, Yuuki Sakai, Kenji Nagata, Mitsutomo Abe, Ichiro Terashima, Wataru Yamori

An environment-responsive SCLA-type GRAS protein controls reproductive strategy in Marchantia polymorpha

David J. Hoey, Philip Carella, Weibing Yang, Sebastian Schornack

Vascular Transcription Factor TMO5 Regulates PIN1 Polarity and Organogenesis Downstream of MONOPTEROS in the Shoot Meristem

Abdul Kareem, Carolyn K Ohno, marcus G heisler

Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina

Christine T. Nolan, Ian Campbell, Anna Farrell-Sherman, Bryan A. Briones Ortiz, Kerry A. Naish Ph.D, Veronica Di Stilio Ph.D, James E. Kaldy Ph.D, Cinde Donoghue Ph.D, Jennifer L. Ruesink Ph.D, Takato Imaizumi Ph.D

Heat-Triggered Transcriptional Reprogramming in Microspores Disrupts Progression of Pollen Development in Brassica napus L

Neeta Lohani, Mohan B. Singh, Prem L. Bhalla

Early seedling development in dark conditions is directly controlled by plastids through the GUN1-dependent plastid retrograde pathway

Salek Ahmed Sajib, Michał Bykowski, Pedro Barreto, Caroline Mauve, Etienne Delannoy, Sophie Blanchet, Rim Chamas, Markus Schwarzländer, Łucja Kowalewska, Bertrand Gakière, Livia Merendino

Arabidopsis thaliana LSM7 is essential for auxin-mediated regulation of SAUR genes and thermomorphogenesis

Sarah Muniz Nardeli, Vasiliki Zacharaki, Nelson Rojas-Murcia, Silvio Collani, Kai Wang, Martin Bayer, Markus Schmid, Daniela Goretti

BPMs regulate Arabidopsis seedling development by promoting auxin-independent degradation of the Aux/IAA protein IAA10

Zhaonan Ban, Yueh-Ju Hou, Ellyse Ku, YingLin Zhu, Yun Hu, Natalie Karadanaian, Yunde Zhao, Mark Estelle

Cytokinin acts as a systemic signal coordinating reproductive effort in Arabidopsis

Darya Volkava, Sona Valuchova Bukovcakova, Pavlina Mikulkova, Jana Pecinkova, Jan Skalak, Jan Hejatko, Karel Riha

Identification of regulatory promoter sequences directing MtCP6 transcription at the onset of nodule senescence in Medicago truncatula

Li Yang, Lisa Frances, Fernanda de Carvalho-Niebel, Pierre Frendo, Eric Boncompagni

Vascular Transcription Factor TMO5 Regulates PIN1 Polarity and Organogenesis Downstream of MONOPTEROS in the Shoot Meristem

Abdul Kareem, Carolyn Ohno, Marcus G. Heisler

Amyloplasts are necessary for full gravitropism in thallus of Marchantia polymorpha

Mimi Hashimoto-Sugimoto, Takuya Norizuki, Shoji Segami, Yusaku Ohta, Noriyuki Suetsugu, Takashi Ueda, Miyo Terao Morita

Morphological and molecular effects of short-term water deficiency in barley stamen maturation

Richard Lange, Youjun Zhang, Alisdair R. Fernie, Iván F. Acosta

MYB68 regulates radial endodermal differentiation and suberin patterning

Leonie Kraska, Josep Mercadal Melia, Ryohei Thomas Nakano, David Molina, Pau Formosa-Jordan, Laura Ragni, Tonni Grube Andersen

| Evo-devo

Acute Triclosan Exposure Alters Mitochondrial Form and Function in Xenopus laevis Tadpoles, Including the Developing Brain

Alex H Thompson, Christopher K Thompson

Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function

Can Liu, Hongya Liu, Hongyu Li, Deguang Yang, Ye Li, Rui Wang, Jiashu Zhu, Shuqin Ma, Suzhen Guan

Hallmarks of uterine receptivity predate placental mammals

Silvia Basanta, Daniel J. Stadtmauer, Jamie D. Maziarz, Caitlin E. McDonough-Goldstein, Alison G. Cole, Gülay Dagdas, Günter P. Wagner°, Mihaela Pavličev

Archaic Adaptive Introgression in Modern Human Reproductive Genes

Christopher Kendall, Amin Nooranikhojasteh, Esteban Parra, Michael A. Schillaci, Bence Viola

FOXP Genes Regulate Purkinje Cell Diversity in Cerebellar Development and Evolution

Nagham Khouri-Farah, Qiuxia Guo, Thomas Perry, Ryan Dussault, James Y.H. Li

In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects

Eric A. Rhon-Calderon, Cassidy N. Hemphill, Alexandra J. Savage, Laren Riesche, Richard M. Schultz, Marisa S. Bartolomei

Characterizing the rates and patterns of de novo germline mutations in the aye-aye (Daubentonia madagascariensis)

Cyril J. Versoza, Erin E. Ehmke, Jeffrey D. Jensen, Susanne P. Pfeifer

Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses

Kelsie E Hunnicutt, Colin Callahan, Sara Keeble, Emily C. Moore, Jeffrey M. Good, Erica L. Larson

Thermal Plasticity of Stage Specific Development Time in Drosophila melanogaster under Shifting Temperatures

Aradhya Chattopadhyay, Rishav Roy, Payel Biswas, Shampa M. Ghosh

Upstream open reading frames buffer translational variability during Drosophila evolution and development

Yuanqiang Sun, Yuange Duan, Peixiang Gao, Chenlu Liu, Kaichun Jin, Shengqian Dou, Wenxiong Tang, Hong Zhang, Jian Lu

Gestation length drives brain size and litter size variation in eutherian mammals

Thodoris Danis, Dana Lin, Daniel S. Caetano, Gregory F. Funston, Antonis Rokas

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Sara Nolbrant, Jenelle L. Wallace, Jingwen Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer, Alex A. Pollen

Symbiosis collapses during development of asexual offspring in the absence of heterotrophic feeding in a model cnidarian-algal symbiosis

Samuel A. Bedgood, Keyla Plichon, Virginia M. Weis

Melanophore and fluoroleucophore synergistically photo-protect the Arabian killifish, Aphanius dispar, embryo from ultraviolet light

Maryam Alenize, Rashid Minhas, Tetsuhiro Kudoh

Conserved mitochondrial reactive oxygen species and HIF1-alpha signalling during an embryonic critical period directs subsequent nervous system development

Daniel Sobrido-Cameán, Bramwell Coulson, Matthew C.W. Oswald, Tom Pettini, Richard A. Baines, Matthias Landgraf

Antibiotic treatment and microbiome depletion slow cnidarian regeneration

Jeric Da-Anoy, Kyle Toyama, Oliwia Jasnos, Audrey Wong, Thomas D. Gilmore, Sarah W. Davies

Genetic Characterization of the Cell Types of in Developing Feathers, and the Evolution of Feather Complexity

Cody Limber, Günter P. Wagner, Richard O. Prum

The genome of a sea spider corroborates a shared Hox cluster motif in arthropods with reduced posterior tagma

Nikolaos Papadopoulos, Siddharth S. Kulkarni, Christian Baranyi, Bastian Fromm, Emily V.W. Setton, Prashant P. Sharma, Andreas Wanninger, Georg Brenneis

PFAS Compounds PFOA and Gen X are Teratogenic to Sea Urchin Embryos

Alexandra T. Lion, Sophie M. Bodine, Kelley R. McCutcheon, Mayank Ghogale, Santhan Chandragiri, Deema Abayawardena, Bikram D. Shrestha, Abigail Descoteaux, Kathryn Alvarez, J’nesse A. Balkman, Breelyn Cocke, Athula H. Wikramanayake, Jennifer Schlezinger, Joyce Y. Wong, Vivek N. Prakash, Cynthia A. Bradham

Effect of the daily exposure of 1.7 GHz LTE electromagnetic field in early fetal brain development using a human brain organoid model of the cerebral cortex

Gyu Yeon Park, Ya Qi Pan, Yoon-Jeong Choi, Nam Kim, Sangbong Jeon, Kiwon Song

Structural molecular and developmental evidence for cell-type diversity in cnidarian mechanosensory neurons

Julia Baranyk, Kristen Malir, Miguel A. P. Silva, Sakura Rieck, Gracie Scheve, Nagayasu Nakanishi

Cell Biology

A novel CCDC112-dependent process of sperm midpiece formation and epididymal maturation

Maddison L. Graffeo, Joseph Nguyen, Farin Yazdan Parast, D. Jo Merriner, Jessica E.M. Dunleavy, Denis Korneev, Hidenobu Okuda, Anne E. O’Connor, Donald F. Conrad, Reza Nosrati, Brendan Houston, Moira K. O’Bryan

Uneven mitochondrial segregation during embryonic neurogenesis

Benjamin Bunel, Rosette Goiame, Xavier Morin, Evelyne Fischer

Endothelial Rho kinase controls blood vessel integrity and angiogenesis

Martin Lange, Caitlin Francis, Jessica Furtado, Young-Bum Kim, James K Liao, Anne Eichmann

Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

Eunkyu Sung, Shohei Murakami, Masanobu Morita, Tomoaki Ida, Takaaki Akaike, Hozumi Motohashi

AI-assisted imaging screening reveals mechano-molecular tissue organizers and network of signaling hubs

Cristina Bertocchi, Juan José Alegría, Sebastián Vásquez-Sepúlveda, Rosario Ibanez-Prat, Aishwarya Srinivasan, Ignacio Arrano-Valenzuela, Barbara Castro-Pereira, Catalina Soto-Montandon, Alejandra Trujillo-Espergel, Gareth I. Owen, Pakorn Kanchanawong, Mauricio Cerda, Giovanni Motta, Ronen Zaidel-Bar, Andrea Ravasio

Revealing the Complexity of the Epicardial Secretome: Characterization and Functional Assessment of Epicardium-Derived Extracellular Vesicles and Matrix

Cláudia C. Oliveira, José Córdoba, John R. Pearson, Elizabeth Guruceaga, Ernesto Marín-Sedeño, Melissa García-Caballero, Juan Antonio Guadix, José M. Pérez-Pomares, Adrián Ruiz-Villalba

Rab2B promotes chaperonin-mediated actin folding and prevents developmental transcription reprogramming and quiescence in trypanosomes

Feng-Jun Li, Xiaoduo Dong, Yameng Huang, Donghui Hu, Eunyoung Chae, Cynthia Y. He

Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis

Benjamin Bunel, Rosette Goiame, Xavier Morin, Evelyne Fischer

Asymmetric stem cell division maintains genetic heterogeneity of tissue cells

Muhammed Burak Bener, Boris M. Slepchenko, Mayu Inaba

Laminin β4 is required for the development of human peripheral sensory neurons

Kenyi Saito-Diaz, Tripti Saini, Archie Jayesh Patel, Christina James, Kimata Safi Thomas, Trinity Nora Knight, Stephanie Beatrice Gogita, Nadja Zeltner

Tissue Context Drives Regional Differences in Trophoblast Differentiation in Fetal Membranes and Chorionic Villi

Liheng (Henry) Yang, Allyson Caldwell, Carolyn B. Coyne

Modelling

Quantifying the intricacies of biological pattern formation: A new perspective through complexity measures

Jurgen Riedel, Chris P. Barnes

Morphodynamics of tip growing cells

Gareth Wyn Jones, Otger Campás, L. Mahadevan

Quantitative guiding of developmental cell fate transitions using gene-free modelling

Ismail Hajji, Eric D. Siggia, Francis Corson, Wolfgang Keil

Tools & Resources

Enhancing cryopreservation of human iPSCs: Bottom-up vs Conventional freezing geometry

Fernando Teodoro, Soukaina El-Guendouz, Rafaela Neves, Andreia Duarte, Miguel A. Rodrigues, Eduardo P. Melo

Highly efficient XIST reactivation in female hPSC by transient dual inhibition of TP53 and DNA methylation during Cas9 mediated genome editing

Nami Motosugi, Keita Hasegawa, Natsumi Kurosaki, Erika Kawaguchi, Kenji Izumi, Yumi Iida, Misaki Higashiseto, Keiko Yokoyama, Ayumi Sasaki, Kazuhiko Nakabayashi, Atsushi Fukuda

The Wnt1-Cre2 transgene causes aberrant recombination in non-neural crest cell types

Shashank Gandhi, Emily J. Du, Edivinia S. Pangilinan, Richard M. Harland

Comparative Analysis of Neural Crest Development in the Chick and Mouse

JA Morrison, I Pushel, R McLennan, MC McKinney, MM Gogol, A Scott, R Krumlauf, PM Kulesa

HumanTestisDB: A Comprehensive Atlas of Testicular Transcriptomics and Cellular Interactions

Mengjie Wang, Laihua Li, Qing Cheng, Hao Zhang, Zhaode Liu, Yiqiang Cui, Jiahao Sha, Yan Yuan

Streamlining Asymmetry Quantification in Fetal Mouse Imaging: A Semi-Automated Pipeline Supported by Expert Guidance

S.M. Rolfe, D. Mao, A. M. Maga

3D Reconstruction of Neuronal Allometry and Neuromuscular Projections in Asexual Planarians Using Expansion Tiling Light Sheet Microscopy

Jing Lu, Hao Xu, Dongyue Wang, Yanlu Chen, Takeshi Inoue, Liang Gao, Kai Lei

Contrast-Enhanced Micro-CT Imaging of a Foetal Female Pelvic Floor Reveals Anatomical Details

Dea Aaldijk, Sebastian Halm, Diana N. Liashchenko, David Haberthür

The White Sea littoral oligochaete Lumbricillus sp. as a model for annelid development studies

Ekaterina P. Matveicheva, Tatiana V. Neretina, Irina A. Ekimova, Victoria V. Konduktorova, Maria L. Semenova, Denis A. Nikishin

Human blastocyst formation in an embryo culture medium mimicking human uterine pH and fluid composition

Miriam S Zagers, Maitane Laverde, Majid Tarahomi, Hubert Joris, Sebastiaan Mastenbroek

VNC-Dist: A machine learning-based tool for quantification of neuronal positioning in the ventral nerve cord of C. elegans

Saber Saharkhiz, Mearhyn Petite, Tony Roenspies, Theodore Perkins, Antonio Colavita

In vivo human uterine temperature, pH, and uterine fluid composition analysis

Majid Tarahomi, Miriam S. Zagers, Simin Zafardoust, A. Mohammadzadeh, Zohre Fathi, Hasti Sareban, Farnaz Fatemi, Soleimani Fakhr, Geert Hamer, Sjoerd Repping, Femke Schrauwen, Jan P. van Straalen, Frédéric M. Vaz, Madelon van Wely, Sebastiaan Mastenbroek

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases

Alek G Erickson, Sergey Isaev, Artem Artemov, Jingyan He, Bettina Semsch, Aliia Murtazina, Jia Sun, Katrin Mangold, Anthi Chalou, Jonas Frisen, Michael Ratz, Emma Andersson, Peter V. Kharchenko, Igor Adameyko

Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols

Julia Naas, Meritxell Balmãna, Laurenz Holcik, Maria Novatchkova, Lina Dobnikar, Thomas Krausgruber, Sabrina Ladstätter, Christoph Bock, Arndt von Haeseler, Christopher Esk, Jürgen A. Knoblich

From naïve pluripotency to human neural organoids through a three-dimensional morphogenetic continuum

Cecilia Laterza, Elisa Cesare, Hannah T. Stuart, Martina D’Ercole, Alessia Gesualdo, Maria Grazia La Barbera, Sara Brignani, Carmela Ribecco, Roberta Polli, Roberta Frison, Silvia Angiolillo, Andrea Maset, Onelia Gagliano, Davide Cacchiarelli, James Briscoe, Elly M. Tanaka, Alessandra Murgia, Nicola Elvassore

Holistic genetic barcoding reveals a lineage tree of tissue macrophage development

Larissa Frank, Daniel Postrach, Maurice Langhinrichs, Thomas Höfer, Hans-Reimer Rodewald

Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics

Theo Perochon, Zeljka Krsnik, Marco Massimo, Yana Ruchiy, Alejandro Lastra Romero, Elyas Mohammadi, Xiaofei Li, Katherine R Long, Laura Parkkinen, Klas Blomgren, Thibault Lagache, David A Menassa, David Holcman

A genome-scale single cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines

Claudia Feng, Elin Madli Peets, Yan Zhou, Luca Crepaldi, Sunay Usluer, Alistair Dunham, Jana M Braunger, Jing Su, Magdalena E Strauss, Daniele Muraro, Kimberly Ai Xian Cheam, Marc Jan Bonder, Edgar Garriga Nogales, Sarah Cooper, Andrew Bassett, Steven Leonard, Yong Gu, Bo Fussing, David Burke, Leopold Parts, Oliver Stegle, Britta Velten

A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord

Jelly HM Soffers, Erin Beck, Daniel Sytkowski, Marianne Maughan, Devarakonda Devasi, Yi Zhu, Beth Wilson, Yu-Chieh David Chen, Ted Erclik, James W. Truman, James B. Skeath, Haluk Lacin

Multi-modal refinement of the human heart atlas during the first gestational trimester

Christopher De Bono, Yichi Xu, Samina Kausar, Marine Herbane, Camille Humbert, Sevda Rafatov, Chantal Missirian, Mathias Moreno, Weiyang Shi, Yorick Gitton, Alberto Lombardini, Ivo Vanzetta, Séverine Mazaud-Guittot, Alain Chédotal, Anaïs Baudot, Stéphane Zaffran, Heather C. Etchevers

Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping

Daniel Postrach, Colin E. J. Pritchard, Larissa Frank, Tom van Leeuwen, Hendrik A. Messal, Paul Krimpenfort, Jacco van Rheenen, Hans-Reimer Rodewald

Optimizing PSC culture for generating neural organoids

Magdalena A. Sutcliffe, Pia Jensen, Joycelyn Tan, Charles A.J. Morris, Daniel Fazakerley, Martin R. Larsen, Madeline A. Lancaster

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