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PhD positions in Quantitative Stem Cell Biology in Dortmund

Posted by , on 30 October 2015

Closing Date: 15 March 2021

Two PhD positions in the area of quantitative stem cell biology are available in the laboratory of Christian Schroeter, starting in spring 2016 at the Max Planck Institute for Molecular Physiology in Dortmund, Germany.

The aim of our research is to understand how pluripotent stem cells receive, process and integrate signals to take lineage decisions. Now that most of the important genes and proteins involved in differentiation decisions have been identified, we want to investigate the functions of the interaction networks formed by these molecules. In particular, we will ask questions such as: How do cells measure quantities of extracellular signals, and how do they encode this information in the dynamic activity of signal transduction networks? How are different signals integrated? How are fate decisions coordinated in cell populations to form tissues?

Multi-color reporter ES cells to interrogate signal integration in fate decision-making at the single cell level
Multi-color reporter ES cells to interrogate signal integration in fate decision-making at the single cell level

Successful candidates will address these questions using mainly mouse embryonic stem cells as a model system, and apply a combination of genetic engineering, molecular biology, immunohistochemistry and live cell microscopy to investigate the dynamics of decision-making processes in single cells. A strong focus of the projects will be on cutting edge live-cell imaging approaches. Together with collaborators we will use the resulting quantitative, dynamic data to develop predictive mathematical models for information processing and decision-making in pluripotent cells.

For further information about the lab and the Max Planck Institute for Molecular Physiology, please visit the lab’s website: http://www.mpi-dortmund.mpg.de/3257493/Dr_C_Schroeter

The full job ad is posted here: http://www.mpi-dortmund.mpg.de/3264913/job_full_offer_9714072?c=1879013

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