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Post-doctoral position (2 years) Use of stem cells to generate tendons

Posted by , on 1 June 2011

Closing Date: 15 March 2021

A 2 year post-doc position is available from October 2011 in Delphine DUPREZ’s team, in Paris.

Tendon and ligament injuries are common clinical problems during aging or following accidents. No treatment currently exists to restore injured or defective tendon/ligament to its normal condition. The ultimate aim of this project is to build an in vitro tendon (or ligament) for implantation into patients with defective tendons. The global strategy is to use the knowledge that we have acquired (and that we are currently acquiring) concerning tendon formation during embryonic development using the chick and mouse models (Lejard et al., 2011 J. Biol. Chem 286(7), 5855-5867, Wang et al., 2010 Dev Cell, 18, 643-654, for review Tozer and Duprez, 2005, Birth Defects Res C Embryo Today. 75(3), 226-36) in order to establish an artificial tendon.

The project will involve cell culture of adult mesenchymal stem cells and transfection experiments with the appropriate factors in order to trigger cell differentiation towards a tendon phenotype. The project will also require in vivo manipulations in chick embryos, the use of mouse mutant lines and the use of rat tendon injury models.

A background in mesenchymal stem cells and/or cell culture will be an advantage.

Applicants may be of any nationality and should have obtained the equivalent of a PhD. Salary will be at least 2500 Euros per month (depending upon experience). Applications including a CV, a description of previous research experience, and 2 or 3 names of referees should be sent to Delphine DUPREZ to Delphine.duprez@upmc.fr

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