Closing Date: 31 March 2021
The HOUART lab is seeking to appoint three postdoctoral research associates to join a 5-year Wellcome Trust-funded research programme in developmental neurobiology. The programme aims to understand the role of axonal splicing factors and intron retaining transcripts in neuronal maturation and degeneration. Our nervous system crucially relies on local fast decisions taken long distance from the neuronal cell body. The mechanisms by which these decisions are spatio-temporally controlled remain obscure. We found that axonal splicing factors and intron-retaining mRNAs are key players in the process. We seek to understand the fundamental molecular and cellular roles they play locally in the dynamic control of neuronal connectivity, using animal models (zebrafish) and cell culture approaches.
The research programme will require expertise in zebrafish genetics, transcriptomics, proteomics, high-resolution (live and fixed) molecular imaging, and sophisticated computational analytical methods. We wish to appoint one scientist with expertise in cutting-edge high-resolution/molecular imaging technologies; one with strong zebrafish neurobiology background and one with very strong protein/RNA biology experience.
Prof. Corinne Houart is a member and Deputy Head of the outstanding Centre for Developmental Neurobiology and MRC Centre for NeuroDevelopmental Disorders at King’s College London. Her lab is affiliated member of the Francis Crick Institute. This rich research environment provides world-class research facilities to the post holders.
Deadline for application 31st March 2021. For further information, please contact Prof. Corinne Houart, email@example.com