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Postdoctoral position in comparative tissue morphogenesis @ Martinez-Morales lab.

Posted by , on 17 December 2019

Closing Date: 15 March 2021

Postdoctoral position.

Centro Andaluz de Biología del Desarrollo (CABD), Seville.
Juan R. Martinez-Morales Lab (jrmarmor@upo.es) is recruiting competitive
postdoctoral researchers to participate in an interdisciplinary project on comparative
tissue morphogenesis

Research project/ Research Group description:
The main focus of our laboratory is to study cellular and molecular mechanisms
involved in the morphogenesis of the vertebrate eye. Using the teleost models
zebrafish and medaka, we investigate the machinery driving the folding of the retinal
neuroepithelium.. Although it is generally accepted that optic cup formation follows a
tissue-intrinsic program in vertebrates, several mechanisms have been postulated
(basal constriction, rim involution) and some important differences in cell behaviour
have been reported among species. Many important questions still remain open. Which
is the relative contribution of each mechanism to the folding of the optic cup? Do they
act in a cooperative manner? Do they have the same regulatory weight in different
species? To answer these questions, we aim to integrate genetic information, imaging
analysis of cell shape changes, and tensional forces distribution into coherent
computational models able to predict the key morphogenetic rules that shape the entire
organ. We plan to extend our observations to mammalian tissue, by examining cell
shape changes and tensions in 3D retinal organoids developed in vitro. A key aspect of
the project is to understand how classical signalling events, which have proved to be
essential for the proper patterning of the organ, act in coordination with tensional
forces. This highly interdisciplinary approach, combining genetics, imaging, biophysics
and computational modelling should yield information relevant not only to understand
optic cup formation, but also to deduce general self-organization principles of the living
matter.

Relevant Publications:

Letelier et al. (2018a) Nat Genetics, Letelier et al (2018b) PNAS, Nicolás-Pérez et
al (2016). eLife; Gago-Rodrigues et al (2015). Nat Comm ; Tena et al (2014) Genome Research. 24(7):;
Bogdanovic et al (2012). Developmental Cell. 23 (4).
For a full list: https://www.ncbi.nlm.nih.gov/pubmed/?term=Martinez-morales+JR

Job position description:
Given the interdisciplinary character of the project above described, we are seeking
talented and highly motivated postdoctoral researchers with a background either in
Developmental Biology or in Biophysics. Previous experience with teleost models will
be well received. The candidates should have good communication skills, critical for
ensuring the success of the team effort. We offer full support to apply for external
funding in upcoming postdoctoral call “Juan de la Cierva” (deadline-21st January 2020).

Contact information:
Email: jrmarmor@upo.es
Phone: + 34 954977827

Web pages :
http://cellcollectives.com/dt_doctors/control-of-epithelial-morphogenesis-in-vertebrates/

http://www.cabd.es/en-research_groups-97-221-control-of-epithelial-morphogenesis-in-vertebrates-summary.html




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