Postdoctoral position in Mouse Embryonic Development and Stem Cell Biology

We offer one fully-funded postdoctoral position up to five years in the Laboratory of Genome Integrity located at the National Institutes of Health (NHI/NCI, Bethesda, MD).

Our laboratory uses human and mouse embryonic stem cells (ESCs) as well as mouse embryos to understand the molecular mechanisms underlying the maintenance/exit of pluripotency and self-renewal. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are our scientific interests.

The applicant should have or about to have a PhD in Developmental Biology, Genetics or similar, and should have demonstrated expertise on molecular biology/mammalian tissue culture. Knowledge in mouse embryology, computational biology and next generation sequencing technologies will be considered as an advantage.

We seek a highly motivated, creative individual, eager to learn and develop new technologies and complex cell systems based on live cell/embryo imaging, single-cell technologies, 3D modelling and CRISPR-based editing interested in understanding how a single cell can develop into a complex multicellular organism in vitro and in vivo.

Please send a brief cover letter, CV and three reference letters via e-mail to:

sergio.ruizmacias@nih.gov

https://ccr.cancer.gov/Laboratory-of-Genome-Integrity/sergio-ruiz-macias

• Mayor-Ruiz C, et al. ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes & Dev. 32: 568-576, 2018.
• Olbrich T, et al. A p53-dependent response limits the viability of mammalian haploid cells. Proc Natl Acad Sci U S A. 114: 9367-9372, 2017.

• Ruiz S, et al. A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors. Mol Cell. 62: 307-13, 2016.
• Ruiz S, et al. Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nature Commun. 6: 8036, 2015.
• Ruiz S, et al. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 109: 17196-201, 2012

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